Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions
Abstract
:1. Introduction
2. Methods
2.1. Designs
2.2. Participants
2.3. Measurements
2.4. DNA Methylation and Methylation Age Calculation
2.5. Statistical Analysis
3. Results
3.1. Demographic and General Characteristics of Participants
3.2. Associations among DNA Methylation, Symptoms, and Resilience
3.3. Changes to DNA Methylation Age, Symptoms, and Resilience before and after Intervention
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Categories | Total (n = 10) | Control (n = 4) | Intervention (n = 6) |
---|---|---|---|---|
Chronological age * (years) | 71.40 ± 9.16 | 77.75 ± 2.22 | 67.17 ± 9.70 | |
Gender | Male | 3 (30.0) | 2 (50.0) | 1 (16.7) |
Female | 7 (70.0) | 2 (50.0) | 5 (83.3) | |
Race | White | 8 (80.0) | 3 (75.0) | 5 (83.3) |
Black or African-American | 2 (20.0) | 1 (25.0) | 1 (16.7) | |
Education | Less than college | 4 (40.0) | 2 (50.0) | 2 (33.3) |
College Graduate | 6 (60.0) | 2 (50.0) | 4 (66.7) | |
Employment | Employed | 2 (20.0) | 1 (25.0) | 1 (16.7) |
Not employed | 8 (80.0) | 3 (75.0) | 5 (83.3) | |
Marital status | Married | 2 (20.0) | 0 (0.0) | 2 (33.3) |
Never married, divorced, or widowed | 8 (80.0) | 4 (100.0) | 4 (66.7) | |
Cancer site | Breast | 3 (30.0) | 1 (25.0) | 2 (33.3) |
Prostate | 2 (20.0) | 1 (25.0) | 1 (16.7) | |
Others | 5 (50.0) | 2 (50.0) | 3 (50.0) |
Variables | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
1. Δ DNA methylation age (Δ Age acceleration) | 1 | −0.145 | 0.235 | 0.684 | 0.493 | −0.377 | −0.897 * |
2. Δ Pain | 1 | 0.378 | 0.221 | 0.213 | 0.152 | 0.086 | |
3. Δ Fatigue | 1 | 0.39 | 0.027 | 0.119 | −0.021 | ||
4. Δ Cognitive dysfunction | 1 | −0.54 | −0.268 | 0.356 | |||
5. Δ Perceived cognitive difficulty | 1 | 0.165 | −0.572 | ||||
6. Δ Insomnia | 1 | 0.156 | |||||
7. Δ Resilience | 1 |
Measures | Control (n = 4) | Intervention (n = 6) | p | ||||
---|---|---|---|---|---|---|---|
T1 (Pre) | T2 (Post) | Mean Difference | T1 (Pre) | T2 (Post) | Mean Difference | ||
DNA methylation age (years) * | 74.90 ± 1.11 | 75.47 ± 0.32 | 0.57 ± 0.80 | 66.77 ± 7.68 | 65.93 ± 8.94 | −0.83 ± 1.26 | 0.200 |
Age acceleration (years) * | −2.10 ± 1.91 | −1.47 ± 1.89 | 0.57 ± 0.80 | 2.10 ± 4.79 | 1.27 ± 4.02 | −0.83 ± 1.26 | 0.200 |
Pain | 45.68 ± 6.51 | 52.03 ± 10.63 | 6.35 ± 5.55 | 53.42 ± 11.88 | 51.60 ± 10.93 | −1.82 ± 11.68 | 0.257 |
Fatigue | 44.08 ± 7.63 | 48.78 ± 3.94 | 4.70 ± 10.58 | 50.80 ± 5.21 | 44.93 ± 6.55 | −5.86 ± 8.00 | 0.067 |
Cognitive decline | 23.50 ± 5.20 | 24.25 ± 4.50 | 0.75 ± 1.50 | 26.75 ± 3.20 | 24.50 ± 2.08 | −2.25 ± 3.30 | 0.200 |
Perceived cognitive difficulty | 82.75 ± 17.63 | 85.25 ± 14.66 | 2.50 ± 5.20 | 70.83 ± 22.60 | 67.83 ± 22.75 | −3.00 ± 17.54 | 0.914 |
Insomnia | 15.75 ± 3.86 | 14.50 ± 7.59 | −1.25 ± 4.79 | 17.33 ± 6.25 | 13.33 ± 4.76 | −4.00 ± 6.78 | 0.762 |
Resilience | 34.50 ± 4.80 | 35.00 ± 4.00 | 0.50 ± 2.08 | 33.33 ± 11.04 | 36.17 ± 5.46 | 2.83 ± 6.43 | 0.914 |
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Lukkahatai, N.; Park, J.; Jia, H.M.; Martin, D.; Li, J.; Sheng, J.Y.-S.; Gill, J.; Saligan, L.N.; Stearns, V.; Carducci, M. Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions. Biomedicines 2023, 11, 3076. https://doi.org/10.3390/biomedicines11113076
Lukkahatai N, Park J, Jia HM, Martin D, Li J, Sheng JY-S, Gill J, Saligan LN, Stearns V, Carducci M. Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions. Biomedicines. 2023; 11(11):3076. https://doi.org/10.3390/biomedicines11113076
Chicago/Turabian StyleLukkahatai, Nada, Jongmin Park, Hejingzi Monica Jia, Daniel Martin, Junxin Li, Jennifer Yeong-Shin Sheng, Jessica Gill, Leorey N. Saligan, Vered Stearns, and Michael Carducci. 2023. "Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions" Biomedicines 11, no. 11: 3076. https://doi.org/10.3390/biomedicines11113076