Development and Validation of Machine Learning Models to Classify Artery Stenosis for Automated Generating Ultrasound Report
Abstract
:1. Introduction
2. Methods
2.1. Data Collection
2.2. Variables Collection
2.3. Handling Imbalanced Dataset
2.4. Statistical Analysis
3. Results
3.1. Patient Selection
3.2. Patient Distribution
3.3. Important Predictors of ECCD
3.4. Performance of Machine Learning Models to Predict Stenosis in ECCD
3.5. Important Predictors of TCD
3.6. Performance of AI Models to Predict Stenosis in TCD
3.7. Manual Evaluation of Inconsistency
4. Discussion
Limitation
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Item | Root Cause | ECCD | TCD | Total |
---|---|---|---|---|
1 | Incomplete report | 2 | 0 | 2 |
2 | Misplacement of category | 13 | 1 | 14 |
3 | Detect values are different with report comments | 5 | 0 | 5 |
Total | 20 | 1 | 21 |
Characteristics | Female (n = 228) | Male (n = 235) |
---|---|---|
Age (mean ± SD, range, yrs.) | 63.0 ± 14.5 (18–96) | 63.9 ± 14.1 (19–99) |
Site of evaluation (no. of patients (%)) | ||
Rt’-ICA | 227 (99.6) | 232 (98.7) |
Lt’-ICA | 227 (99.6) | 232 (98.7) |
Rt’-VA | 228 (100.0) | 230 (97.9) |
Lt’-VA | 227 (99.6) | 231 (98.3) |
VA Total Flow | 228 (100.0) | 227 (96.6) |
Aberrant hemodynamics (no. of patients (%)) | ||
Rt’-ICA | 3 (1.3) | 10 (4.3) |
Lt’-ICA | 2 (0.9) | 13 (5.5) |
Rt’-VA | 10 (4.4) | 22 (9.4) |
Lt’-VA | 9 (3.9) | 12 (5.1) |
VA Total Flow | 26 (11.4) | 36 (15.3) |
Characteristics | Female (n = 42) | Male (n = 33) |
---|---|---|
Age (mean ± SD, range, yr.) | 64.7 ± 13.3 (39–96) | 69.7 ± 13.9 (39–95) |
Site of evaluation (no. of patients (%)) | ||
Rt’-MCA | 12 (28.6) | 22 (66.7) |
Lt’-MCA | 10 (23.8) | 22 (66.7) |
Rt’-VA | 42 (100.0) | 33 (100.0) |
Lt’-VA | 42 (100.0) | 33 (100.0) |
BA | 42 (100.0) | 32 (97.0) |
Aberrant hemodynamics (no. of patients (%)) | ||
Rt’-MCA | 4 (33.3) | 12 (54.5) |
Lt’-MCA | 3 (30.0) | 12 (54.5) |
Rt’-VA | 7 (16.7) | 8 (24.2) |
Lt’-VA | 6 (14.3) | 3 (9.1) |
BA | 5 (11.9) | 4 (12.5) |
Random Forest | Predictors | Mean Decrease Gini |
---|---|---|
Rt’-ICA | Gender | 13.44 |
Age | 80.74 | |
PSV | 77.85 | |
RI | 49.57 | |
Lt’-ICA | Gender | 3.12 |
Age | 61.84 | |
PSV | 86.56 | |
RI | 69.23 | |
Rt’-VA | Gender | 1.44 |
Age | 35.16 | |
Diameter | 30.17 | |
RI | 60.02 | |
Flow rate | 75.95 | |
Lt’-VA | Gender | 1.15 |
Age | 30.28 | |
Diameter | 30.04 | |
RI | 89.89 | |
Flow rate | 60.92 | |
Total VA | Gender | 0.55 |
Age | 8.21 | |
Rt’-diameter | 18.95 | |
Rt’-RI | 7.52 | |
Lt’-diameter | 12.30 | |
Lt’-RI | 10.53 | |
Total Flow rate | 114.22 |
Specific Side/Artery | Model Performance | Accuracy | Sensitivity | Specificity | PPV | NPV |
---|---|---|---|---|---|---|
Rt’-ICA | RF | 0.96 | 1.00 | 0.96 | 0.33 | 1.00 |
LR | 0.87 | 1.00 | 0.87 | 0.14 | 1.00 | |
Lt’-ICA | RF | 0.87 | 0.33 | 0.89 | 0.09 | 0.98 |
LR | 0.89 | 0.33 | 0.91 | 0.11 | 0.98 | |
Rt’-VA | RF | 0.85 | 0.67 | 0.86 | 0.25 | 0.97 |
LR | 0.82 | 0.67 | 0.83 | 0.21 | 0.97 | |
Lt’-VA | RF | 0.88 | 1.00 | 0.88 | 0.27 | 1.00 |
LR | 0.85 | 1.00 | 0.84 | 0.22 | 1.00 | |
Total VA | RF | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
LR | 0.99 | 0.92 | 1.00 | 1.00 | 0.99 |
Random Forest | Predictors | Mean Decrease Gini |
---|---|---|
Rt’-MCA | Gender | 0.18 |
Age | 0.94 | |
Dist. M1 PSV | 1.13 | |
Dist. M1 PI | 1.48 | |
Prox. M1 PSV | 1.55 | |
Prox. M1 PI | 1.20 | |
M2 PSV | 1.19 | |
M2 PI | 1.03 | |
Lt’-MCA | Gender | 0.17 |
Age | 0.77 | |
Dist. M1 PSV | 2.18 | |
Dist. M1 PI | 0.77 | |
Prox. M1 PSV | 1.06 | |
Prox. M1 PI | 1.40 | |
M2 PSV | 1.16 | |
M2 PI | 1.29 | |
Rt’-VA | Gender | 0.21 |
Age | 3.00 | |
PSV | 8.41 | |
PI | 18.69 | |
Lt’-VA | Gender | 0.44 |
Age | 8.35 | |
PSV | 6.21 | |
PI | 15.82 | |
BA | Gender | 0.47 |
Age | 6.07 | |
PSV | 6.27 | |
PI | 17.99 |
Specific Side/Artery | Model Performance | Accuracy | Sensitivity | Specificity | PPV | NPV |
---|---|---|---|---|---|---|
Rt’-MCA | RF | 0.86 | 1.00 | 0.75 | 0.75 | 1.00 |
LR | 0.71 | 1.00 | 0.50 | 0.60 | 1.00 | |
Lt’-MCA | RF | 0.67 | 1.00 | 0.33 | 0.60 | 1.00 |
LR | 0.67 | 1.00 | 0.33 | 0.60 | 1.00 | |
Rt’-VA | RF | 0.60 | 0.33 | 0.67 | 0.20 | 0.80 |
LR | 0.60 | 0.33 | 0.67 | 0.20 | 0.80 | |
Lt’-VA | RF | 0.73 | 0.50 | 0.77 | 0.25 | 0.91 |
LR | 0.53 | 0.50 | 0.54 | 0.14 | 0.88 | |
BA | RF | 0.80 | 0.50 | 0.85 | 0.33 | 0.92 |
LR | 0.87 | 1.00 | 0.85 | 0.50 | 1.00 |
Exam. | Specific Side/Artery | Inconsistent Cases | # of Preference for Original Report | # of Preference for Machine Learning-Based Report |
---|---|---|---|---|
ECCD | Rt’-ICA | 4 | 3 | 1 |
Lt’-ICA | 12 | 9 | 3 | |
Rt’-VA | 13 | 5 | 8 | |
Lt’-VA | 12 | 6 | 6 | |
Total VA | 0 | 0 | 0 | |
TCD | Rt’-MCA | 2 | 2 | 0 |
Lt’-MCA | 1 | 0 | 1 | |
Rt’-VA | 5 | 2 | 3 | |
Lt’-VA | 6 | 1 | 5 | |
BA | 1 | 0 | 1 |
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Yeh, C.-Y.; Lee, H.-H.; Islam, M.M.; Chien, C.-H.; Atique, S.; Chan, L.; Lin, M.-C. Development and Validation of Machine Learning Models to Classify Artery Stenosis for Automated Generating Ultrasound Report. Diagnostics 2022, 12, 3047. https://doi.org/10.3390/diagnostics12123047
Yeh C-Y, Lee H-H, Islam MM, Chien C-H, Atique S, Chan L, Lin M-C. Development and Validation of Machine Learning Models to Classify Artery Stenosis for Automated Generating Ultrasound Report. Diagnostics. 2022; 12(12):3047. https://doi.org/10.3390/diagnostics12123047
Chicago/Turabian StyleYeh, Chih-Yang, Hsun-Hua Lee, Md. Mohaimenul Islam, Chiu-Hui Chien, Suleman Atique, Lung Chan, and Ming-Chin Lin. 2022. "Development and Validation of Machine Learning Models to Classify Artery Stenosis for Automated Generating Ultrasound Report" Diagnostics 12, no. 12: 3047. https://doi.org/10.3390/diagnostics12123047