Thwarting Alzheimer’s Disease through Healthy Lifestyle Habits: Hope for the Future
, Lakshmayya S. V. Nunna 1, Jahanavi Madasu 1, Vishwanutha Shamshabad 1, Mounica Bandela 2 and Vidyani Suryadevara 3,*Round 1
Reviewer 1 Report
The authors describe the review regarding Alzheimer’s disease form the scientifically interesting view. This review is very unique. They conclude and propose that healthy lifestyles associated with many, many modifiable factors is a best alter-native strategy to combat the disease.
Minor points (This may not necessarily need improvement):
Figure 1. It might be better to focus a little more and draw simply.
Table.1. It might be worth adding a little bit to this table about the benefits of vitamins, although this may deviate from the main topic.
4. Conclusions. It might be better to write in detail about the future image that can be expected in this part.
Author Response
Thank you for your valuable comments, we have revised the manuscript based on your inputs:
Comment 1: Figure 1. It might be better to focus a little more and draw simply.
Response: The Figure has been made simple to just show the lifestyle modifications.
Comment 2: Table.1. It might be worth adding a little bit to this table about the benefits of vitamins, althoughthis may deviate from the main topic.
Response: A table and paragraph about vitamins has been added.
Comment 3: 4. Conclusions. It might be better to write in detail about the future image that can be expected in this part.
Response: That has been added.
Reviewer 2 Report
Paper is intended to summarize recent data on the influence of modifiable -healthy life style aspects in the pathomechanisms of AD and to critically discuss the role diet and its conseqences in this process. The idea is relevant, however the review structure should require more complex approach with critical and comprehensive view on the role of dietary components, physical, mental activities, educational level within very complex pathomechanism of various forms of AD (vascular, neurodegenerative dementia ...). Paper should include a clear differentiation between forms and clinical maifestations of AD and their relevant pathomechanisms. References should cover comprehensive world- wide recent relevant literature data on this topic. Paper review is always intended to cover and to critically discuss the recent experimental data from many laboratories and approaches and data should be applied in a ballance manner.
Author Response
Dear Reviewer,
Thank you for your valuable comments.
We have revised the manuscript based on your inputs. We included a paragraph to talk about the different manifestations of AD. The impact of dietary components, physical, mental activities, educational level on the different pathomechanisms of AD has been included in each section, where we talk about the impact of these factors on the different AD signaling mechanisms in the brain.
However, the main focus of this paper is to give the readers about the various lifestyle modifications that could be made to improve cognitive reserve and mitigate the risk of AD. We Thank you again for your valuable inputs and have made changes accordingly.
