Bone as an Endocrine Organ

Topic Information

Dear Colleagues,

Increasing evidence shows that bone is very much an interactive organ in the body and plays an integral role in the functioning or malfunctioning of other organs and tissues. Often, it does this by releasing substances that affect metabolism in ways we could not previously imagine. Some examples of this include the roles of osteocalcin in glucose metabolism and skeletal muscle function and Transforming Growth Factor-Beta in muscle protein degradation. Yet, many questions are unanswered. For example, bone contains and releases substances that are anabolic and catabolic to other tissues. What signals bone to release them and in what quantities? What are the metabolic fates of released calcium, phosphate and magnesium in health and disease? How do these releases affect other organs in different disease states?

Prof. Dr. Gordon L. Klein
Prof. Dr. Antonio Brunetti
Topic Editors

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Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Cells cells	6.0	9.0	2012	16.6 Days	CHF 2700	Submit
Endocrines endocrines	-	-	2020	27.2 Days	CHF 1000	Submit
International Journal of Molecular Sciences ijms	5.6	7.8	2000	16.3 Days	CHF 2900	Submit
Journal of Clinical Medicine jcm	3.9	5.4	2012	17.9 Days	CHF 2600	Submit
Metabolites metabolites	4.1	5.3	2011	13.2 Days	CHF 2700	Submit

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Open AccessCommunication

Vibration Rather than Microgravity Affects Bone Metabolism in Adult Zebrafish Scale Model

by Marta Carnovali, Stefania Zava, Giuseppe Banfi, Angela Maria Rizzo and Massimo Mariotti

Cells 2024, 13(6), 509; https://doi.org/10.3390/cells13060509 - 14 Mar 2024

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Abstract

Gravity and mechanical forces cause important alterations in the human skeletal system, as demonstrated by space flights. Innovative animal models like zebrafish embryos and medaka have been introduced to study bone response in ground-based microgravity simulators. We used, for the first time, adult [...] Read more.

Gravity and mechanical forces cause important alterations in the human skeletal system, as demonstrated by space flights. Innovative animal models like zebrafish embryos and medaka have been introduced to study bone response in ground-based microgravity simulators. We used, for the first time, adult zebrafish in simulated microgravity, with a random positioning machine (RPM) to study bone remodeling in the scales. To evaluate the effects of microgravity on bone remodeling in adult bone tissue, we exposed adult zebrafish to microgravity for 14 days using RPM and we evaluated bone remodeling on explanted scales. Our data highlight bone resorption in scales in simulated microgravity fish but also in the fish exposed, in normal gravity, to the vibrations produced by the RPM. The osteoclast activation in both rotating and non-rotating samples suggest that prolonged vibrations exposure leads to bone resorption in the scales tissue. Stress levels in these fish were normal, as demonstrated by blood cortisol quantification. In conclusion, vibrational mechanical stress induced bone resorption in adult fish scales. Moreover, adult fish as an animal model for microgravity studies remains controversial since fish usually live in weightless conditions because of the buoyant force from water and do not constantly need to support their bodies against gravity. Full article

(This article belongs to the Topic Bone as an Endocrine Organ)

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