Topic Editors

Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital, Matsudo, Chiba, Japan
Division of Nephrology, Department of Internal Medicine, Kashiwa Forest Clinic, Kashiwa, Chiba, Japan

Nephrology and Dialysis: From Bench to Bedside

Abstract submission deadline
31 May 2024
Manuscript submission deadline
31 July 2024
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4751

Topic Information

Dear Colleagues,

Nephrology is a very broad field, ranging from basic laboratory to clinical medicine, and many topics are emerging on a daily basis. Nephrology concerns the study of the kidneys, specifically normal kidney function (renal physiology) and kidney disease (renal pathophysiology), the preservation of kidney health, and the treatment of kidney disease, from diet and medication to renal replacement therapy (dialysis and kidney transplantation). Nephrology also studies systemic conditions that affect the kidneys, such as diabetes and autoimmune disease, and systemic diseases that occur as a result of kidney disease, such as renal osteodystrophy and hypertension. The topic "Nephrology and Dialysis: From Bench to Bedside" includes but is not limited to:

  • Onconephrology;
  • Acute kidney injury and chronic kidney disease;
  • Primary kidney disorders;
  • Glomerular diseases;
  • Tubulointerstitial kidney diseases;
  • Tubular defects;
  • The effects of toxins on the kidney;
  • Disorders of the kidney vasculature;
  • Infections and neoplasms of the kidney;
  • Abnormalities of the kidney, collecting system, and bladder;
  • Kidney function;
  • Diabetic kidney disease;
  • Glomerulonephritis;
  • Cardionephrology;
  • Hypertension and nephrology;
  • ADPKD;
  • Renal vasculitis;
  • Renal and renovascular hypertension;
  • Kidney amyloidosis;
  • Hereditary kidney disease;
  • Renal ischemia;
  • Kidney stones;
  • Renal recovery;
  • Treatment;
  • Renal replacement therapy;
  • Kidney transplantation;
  • Kidney function;
  • Renal imaging;
  • Renal ultrasound.

We are pleased to announce that we have decided to launch a Topic on "Nephrology and Dialysis: From Bench to Bedside". Please take this opportunity to share your daily thoughts on nephrology topics in this project. We look forward to receiving your contribution.

Dr. Eiichi Sato
Dr. Tsukasa Nakamura
Topic Editors

Keywords

  • onconephrology
  • kidney disease
  • kidney function
  • treatment
  • nephrology

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomedicines
biomedicines
4.7 3.7 2013 15.4 Days CHF 2600 Submit
Journal of Clinical Medicine
jcm
3.9 5.4 2012 17.9 Days CHF 2600 Submit
Membranes
membranes
4.2 4.4 2011 13.6 Days CHF 2700 Submit
Metabolites
metabolites
4.1 5.3 2011 13.2 Days CHF 2700 Submit
Reports
reports
0.9 - 2018 20.6 Days CHF 1400 Submit

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Published Papers (4 papers)

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8 pages, 468 KiB  
Article
Solute Clearance Evaluation and Filter Clotting Prediction in Continuous Renal Replacement Therapy
J. Clin. Med. 2023, 12(24), 7703; https://doi.org/10.3390/jcm12247703 - 15 Dec 2023
Viewed by 668
Abstract
Unexpected filter clotting is a major problem in continuous renal replacement therapy (CRRT). Reduced solute clearance is observed prior to filter clotting. This single-center, retrospective, observational study aimed to determine whether reduced solute clearance of low- and medium-molecular-weight molecules in CRRT can predict [...] Read more.
Unexpected filter clotting is a major problem in continuous renal replacement therapy (CRRT). Reduced solute clearance is observed prior to filter clotting. This single-center, retrospective, observational study aimed to determine whether reduced solute clearance of low- and medium-molecular-weight molecules in CRRT can predict filter clotting. Solute clearances of urea and myoglobin (Mb) were measured at 24 h after initiation of continuous hemodiafiltration (CHDF). Clearance per flow (CL/F) was calculated. The primary outcome was clotting of the filter in the subsequent 24 h, and 775 CHDF treatments conducted on 230 patients for at least 24 consecutive hours in our ICU were analyzed. Filter clotting was observed in 127 treatments involving 39 patients. Urea and Mb CL/F at 24 h were significantly lower in the patients who experienced clotting. Further analysis was limited to the first CHDF treatment of each patient to adjust for confounding factors. Multivariate logistic regression analysis revealed that both urea CL/F < 94% and Mb CL/F < 64% were significant predictors of clotting within the next 24 h. Lower urea and Mb CL/F measured at 24 h after CRRT initiation were associated with filter clotting in the next 24 h. Further study is necessary to ascertain whether measurement of urea and MB CL/F will help with avoiding unexpected filter clotting. Full article
(This article belongs to the Topic Nephrology and Dialysis: From Bench to Bedside)
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10 pages, 708 KiB  
Article
Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery
Biomedicines 2023, 11(12), 3244; https://doi.org/10.3390/biomedicines11123244 - 07 Dec 2023
Viewed by 747
Abstract
Background: Early detection of acute kidney injury (AKI) is crucial for timely intervention and improved patient outcomes after cardiac surgery. This study aimed to evaluate the potential of urinary collectrin as a novel biomarker for AKI in this patient population. Methods: In this [...] Read more.
Background: Early detection of acute kidney injury (AKI) is crucial for timely intervention and improved patient outcomes after cardiac surgery. This study aimed to evaluate the potential of urinary collectrin as a novel biomarker for AKI in this patient population. Methods: In this prospective, observational cohort study, 63 patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB) were studied at the Medical University of Vienna between 2016 and 2018. We collected urine samples prospectively at four perioperative time points, and urinary collectrin was measured using an enzyme-linked immunosorbent assay. Patients were divided into two groups, AKI and non-AKI, defined by Kidney Disease: Improving Global Outcomes Guidelines, and differences between groups were analyzed. Results: Postoperative AKI was found in 19 (30%) patients. Urine sample analysis revealed an inverse correlation between urinary collectrin and creatinine and AKI stages, as well as significant changes in collectrin levels during the perioperative course. Baseline collectrin levels were 5050 ± 3294 pg/mL, decreased after the start of CPB, reached their nadir at the end of surgery, and began to recover slightly on postoperative day (POD) 1. The most effective timepoint for distinguishing between AKI and non-AKI patients based on collectrin levels was POD 1, with collectrin levels of 2190 ± 3728 pg/mL in AKI patients and 3768 ± 3435 pg/mL in non-AKI patients (p = 0.01). Conclusions: Urinary collectrin shows promise as a novel biomarker for the early detection of AKI in patients undergoing cardiac surgery on CPB. Its dynamic changes throughout the perioperative period, especially on POD 1, provide valuable insights for timely diagnosis and intervention. Further research and validation studies are needed to confirm its clinical usefulness and potential impact on patient outcomes. Full article
(This article belongs to the Topic Nephrology and Dialysis: From Bench to Bedside)
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10 pages, 2406 KiB  
Case Report
Rare Onset of Tubercular Peritonitis Amidst Chronic Renal Dysfunction
Reports 2023, 6(4), 44; https://doi.org/10.3390/reports6040044 - 22 Sep 2023
Viewed by 1176
Abstract
Tuberculosis Peritonitis is a serious condition, whose diagnosis is established late due to the nonspecific nature of the clinical features, which delays the performance of imaging investigations and, implicitly, the setting of the diagnosis through biopsy and histopathological examination. We report the case [...] Read more.
Tuberculosis Peritonitis is a serious condition, whose diagnosis is established late due to the nonspecific nature of the clinical features, which delays the performance of imaging investigations and, implicitly, the setting of the diagnosis through biopsy and histopathological examination. We report the case of a 49-year-old man who presented in our clinic with nonspecific symptoms and significant nitrogen retention, with ascites fluid detected during the clinical–paraclinical examination, ultimately confirming the diagnosis of bacillary peritonitis. Confirmation of tuberculous etiology through biopsy and/or bacteriological examination is sovereign for the diagnosis. The therapeutic protocol includes three anti-tuberculostatic drugs, for a period of at least 6 months, with or without the combination of corticosteroid therapy during the first months of treatment. The patient evolution under treatment was initially favorable, but due to peritoneal adhesions, it underwent complications later. Full article
(This article belongs to the Topic Nephrology and Dialysis: From Bench to Bedside)
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15 pages, 2361 KiB  
Review
Current Insights into Cellular Determinants of Peritoneal Fibrosis in Peritoneal Dialysis: A Narrative Review
J. Clin. Med. 2023, 12(13), 4401; https://doi.org/10.3390/jcm12134401 - 30 Jun 2023
Cited by 2 | Viewed by 1532
Abstract
Peritoneal fibrosis is the final process of progressive changes in the peritoneal membrane due to chronic inflammation and infection. It is one of the main causes of discontinuation of peritoneal dialysis (PD), apart from peritonitis and cardiovascular complications. Over time, morphological changes occur [...] Read more.
Peritoneal fibrosis is the final process of progressive changes in the peritoneal membrane due to chronic inflammation and infection. It is one of the main causes of discontinuation of peritoneal dialysis (PD), apart from peritonitis and cardiovascular complications. Over time, morphological changes occur in the peritoneal membranes of patients who use PD. Of those are mesothelial-to-mesenchymal transition (MMT), neoangiogenesis, sub-mesothelial fibrosis, and hyalinizing vasculopathy. Several key molecules are involved in the complex pathophysiology of peritoneal fibrosis, including advanced glycosylation end products (AGEs), transforming growth factor beta (TGF-β), and vascular endothelial growth factor (VEGF). This narrative review will first discuss the physiology of the peritoneum and PD. Next, the multifaceted pathophysiology of peritoneal fibrosis, including the effects of hyperglycemia and diabetes mellitus on the peritoneal membrane, and the promising biomarkers of peritoneal fibrosis will be reviewed. Finally, the current and future management of peritoneal fibrosis will be discussed, including the potential benefits of new-generation glucose-lowering medications to prevent or slow down the progression of peritoneal fibrosis. Full article
(This article belongs to the Topic Nephrology and Dialysis: From Bench to Bedside)
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