Topic Editors

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China

Natural Products in Prevention and Therapy of Metabolic Syndrome

Abstract submission deadline
31 December 2023
Manuscript submission deadline
30 June 2024
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964

Topic Information

Dear Colleagues,

Metabolic syndrome is a complex cluster of metabolic disorders, which increase a patient’s risk of developing diabetes mellitus and cardiovascular diseases, the main causes of morbidity and mortality in the world. Despite the availability of many pharmacotherapies, new classes of pharmacological agents capable of reducing overall risk are needed. An accumulating number of studies have indicated that some natural products or molecules are able to modulate metabolic syndrome and its risk factors. This Topic aims to identify and review the latest natural products or molecules that can prevent and treat metabolic syndrome and its risk factors.

Dr. Jianbo Wan
Dr. Ligen Lin
Topic Editors

Keywords

  • natural products
  • metabolic syndrome
  • cardiovascular diseases
  • alcoholic liver disease
  • non-alcoholic liver disease
  • obesity
  • insulin resistance and diabetes
  • dyslipidemia
  • pancreatic β-cell failure

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
BioChem
biochem
- - 2021 15.0 days * CHF 1000 Submit
Biomedicines
biomedicines
4.7 3.7 2013 14.7 Days CHF 2600 Submit
Biomolecules
biomolecules
5.5 8.3 2011 19.2 Days CHF 2700 Submit
International Journal of Molecular Sciences
ijms
5.6 7.8 2000 16.8 Days CHF 2900 Submit
Metabolites
metabolites
4.1 5.3 2011 12.9 Days CHF 2700 Submit
Molecules
molecules
4.6 6.7 1996 13.6 Days CHF 2700 Submit

* Median value for all MDPI journals in the first half of 2023.


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Published Papers (1 paper)

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19 pages, 6277 KiB  
Article
Mixture of Peanut Skin Extract, Geniposide, and Isoquercitrin Improves the Hepatic Lipid Accumulation of Mice via Modification of Gut Microbiota Homeostasis and the TLR4 and AMPK Signaling Pathways
Int. J. Mol. Sci. 2023, 24(23), 16684; https://doi.org/10.3390/ijms242316684 - 24 Nov 2023
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Abstract
Metabolic-dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD) is a global chronic liver disease, and no licensed drugs are currently available for its treatment. The incidence of MASLD is increasing, which could lead to a huge clinical and economic burden. As a [...] Read more.
Metabolic-dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD) is a global chronic liver disease, and no licensed drugs are currently available for its treatment. The incidence of MASLD is increasing, which could lead to a huge clinical and economic burden. As a multifactorial disease, MASLD involves a complex set of metabolic changes, and many monotherapies for it are not clinically effective. Therefore, combination therapies using multiple drugs are emerging, with the advantages of improving drug efficacy and reducing side effects. Peanut skin extract (PSE), geniposide (GEN), and isoquercitrin (IQ) are three natural antiaging components or compounds. In this study, the preventive effects of individual PSE, GEN, and IQ in comparison with the effects of their mixture (MPGI) were examined in a mouse model of high-fat-feed-induced MASLD. The results showed that MPGI could significantly reduce the body and liver weights of mice and improve hepatic steatosis and liver function indicators. Further mechanistic studies showed that PSE, GEN, and IQ worked together by reducing inflammation, modulating the intestinal flora, and regulating the TLR4/NF-κB, AMPK/ACC/CPT1, and AMPK/UKL1/LC3B signaling pathways. It is a promising therapeutic method for preventing MASLD. Full article
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