Regulation of Viral Replication and Cellular Antiviral Mechanisms by Components of SWI/SNF Complex
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 512
Special Issue Editor
Special Issue Information
Dear Colleagues,
SWI/SNF is a prototypic ATP-dependent multiprotein chromatin remodelling complex. It is conserved in all eukaryotes and functions as an epigenetic regulator modulating the transcription of multiple genes involved in development, cell cycle regulation and disease. Many of the components of this complex are tumour suppressors frequently mutated in human cancers. Components of SWI/SNF complex directly or indirectly interact with viral components and influence replication of several viruses including HIV-1, EBV2, HPV17 and SARS-CoV2 and have been shown to exert multifaceted roles in the replication of some of these viruses. Furthermore, SWI/SNF complex also has a role in regulating transcription of interferon signalling genes. How these varied functions of SWI/SNF complex modulates viral replication is not completely understood. This special issue is an effort to bring together what is known about the role of components of SWI/SNF chromatin remodelling complexes in various stages of viral replication to gain insight into how viruses may exploit this machinery for their own purpose. Studies to understand the role of components of SWI/SNF in viral replication may provide a window into some of the unprecedented functions of these complexes and may lead to novel strategies to inhibit viral replication.
Prof. Dr. Ganjam V Kalpana
Guest Editor
Manuscript Submission Information
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Keywords
- SWI/SNF
- BAF complex
- INI1/SMARCB1
- BRG1/SMARCA4
- BRM/SMARCA2
- viruses
- transcription
- late events
- early events
- particle morphogenesis
- RNA mimicry
- chroimatin remodeling
- interferon signalling
