Protein–Protein Interactions in the Discovery of Antiviral Drugs

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 219

Special Issue Editor

E-Mail Website
Guest Editor
1. Translational Proteomics Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada
2. Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada
Interests: protein-protein interactions; particle for arrangement of quaternary structure (PAQosome); RNA polymerases; single-cell proteomics; neurodegenerative disorders; leukodystrophy; zoonotic respiratory viruses; 37TrillionCells initiative; cell-based interception and precision medicine

Special Issue Information

Dear Colleagues,

Protein–protein interactions play essential roles in viral infections. Some viral proteins join together to form protein complexes that exert key roles in the virus life cycle. The RNA polymerase complex is an example. Additionally, some viral proteins interact with host factors during the infection process, usurping the function of these factors in favor of viral functions. Together, these protein–protein interactions are central in the pathophysiology of viral infection. As a consequence, perturbation of these key interactions has the potential to impair virus replication and propagation. Over recent years, a number of molecules, including small chemicals, peptides and antibodies, have been reported to interfere with viral functions by perturbating protein–protein interactions. The molecules showing virus specificity can serve as antiviral agents en route to the discovery of new drugs. This Special Issue of the open access journal Viruses is dedicated to experimental studies or reviews dealing with the use of protein–protein interactions as targets for antiviral drug discovery. This Special Issue also represents a powerful tool in the combat against threatening human viruses.

Dr. Benoit Coulombe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • protein–protein interactions
  • antiviral drug discovery
  • protein target inhibitors

Published Papers

This special issue is now open for submission.
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