HIV and Drugs of Abuse, 3rd Edition
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 70
Special Issue Editors
Interests: neuroinflammation; neuro-immunemodulation; chronic inflammation; brain pathogenesis; HIV associated neurological disorders; drugs of abuse; innate immune response
Special Issues, Collections and Topics in MDPI journals
Interests: neuroinflammation; neurodegenerative disease; host-pathogen interactions; HIV-1; drug abuse; innate immunity; microglia/macrophages; neuroprotection; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Substance use disorders and HIV infection are long-standing public health concerns and frequent comorbidities. HIV continues to cause neurocognitive deficits despite highly effective anti-retroviral therapies that lead to viral suppression. Combined with the neurobehavioral factors underlying substance use and the neurological consequences of addictive drugs, HIV-associated neurological disorders present a range of distinctive characteristics, and there is still no treatment available. The modulation of immune functions by the actions of neurotransmitters released under the influence of such drugs may be one reason for the aggravating effects of addiction on HIV-associated disorders in the central nervous system. Among the addictive drugs, methamphetamine and other stimulants are highly detrimental due to the associated risky behaviors, and due to their effects on neurotransmitters interfering with cellular responses. Given that innate and adaptive immune cells express neurotransmitter receptors, HIV target cells in the context of substance use respond differently than in non-users, particularly in the brain. Polysubstance use is highly prevalent among individuals with addictive behaviors, further complicating the picture. In this Special Issue of Viruses, we aim at integrating information derived from research with humans and animal models, as well as in cells of the immune system, thus providing a unique multidimentional and translational perspective of the clinical and mechanistic interactions between HIV and drugs of abuse that contribute to neurological disorders. Original work performed by interdisciplinary teams will be showcased.
Dr. Maria Cecilia Garibaldi Marcondes
Prof. Dr. Marcus Kaul
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- substance use disorders
- HIV
- HAND
- methamphetamine
