Animal Models in Cancer Research: Advancement and Perspectives

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Anatomy, Histology and Pathology".

Deadline for manuscript submissions: 18 August 2024 | Viewed by 2074

Special Issue Editors


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Guest Editor
Department of Animal Physiology, Veterinary Faculty, Complutense University of Madrid, 28040 Madrid, Spain
Interests: cancer endocrinology; cancer metastasis; reproductive endocrinology; tumors; endocrine disruption; lymphangiogenesis; xenograft model; hormonal analysis; comparative endocrinology; canine and human inflammatory breast cancer; angiogenesis processes
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Animal Physiology, Veterinary Faculty, Complutense University of Madrid, 28040 Madrid, Spain
Interests: histology; pathological anatomy; comparative oncology; endocrinology; domestic and wild animals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is the "exclusive disease" of multicellular animals, and also widely exists in different multicellular species. It is not only humans who are diagnosed with cancer each year, such as melanoma, osteosarcoma, lymphoma and more, but also millions of animals. Based on this, an increasing number of animal models have been used in cancer research. Not only does the application of animal provide a variety of research methods for cancer research, such as genetic engineering and xenotransplantation, but also new research perspectives for the clinical and medical treatment of cancer.

For the most part, veterinarians and doctors are believed to originate from completely different disciplines, with little correlation between them. However, research on animal cancers has greatly enriched the biomedical information base, and is of great significance for human and animal oncology. Unfortunately, many researchers are still unaware of the clinical data value of animal tumor studies.

We hope that through this exchange, scholars can better understand the methods and techniques applied to animal models in cancer research and explore more effective interventions for the disease. We invite you to share your latest achievements and discoveries in this Special Issue.

Dr. Sara Cáceres Ramos
Dr. Paloma Jimena De Andrés Gamazo
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal models
  • cancer
  • tumour
  • histopathological
  • clinical

Published Papers (1 paper)

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Research

15 pages, 2840 KiB  
Article
Cyclooxygenase-2 (COX-2) Expression in Equine Melanocytic Tumors
by José Pimenta, Justina Prada, Isabel Pires and Mário Cotovio
Vet. Sci. 2024, 11(2), 77; https://doi.org/10.3390/vetsci11020077 - 07 Feb 2024
Viewed by 1353
Abstract
Equine melanocytic tumors are common and have an unusual benign behavior with low invasiveness and metastatic rates. However, tumoral mass growth is usually a concern that can have life-threatening consequences. COX-2 is related to oncogenesis, promoting neoplastic cell proliferation, invasion, and metastasis. The [...] Read more.
Equine melanocytic tumors are common and have an unusual benign behavior with low invasiveness and metastatic rates. However, tumoral mass growth is usually a concern that can have life-threatening consequences. COX-2 is related to oncogenesis, promoting neoplastic cell proliferation, invasion, and metastasis. The aim of this study was to evaluate the immunohistochemical expression of COX-2 in equine melanocytic tumors. Through extension and intensity of labeling, 39 melanocytomas and 38 melanomas were evaluated. Of the malignant tumors, 13.2% were negative and 63.2% presented a low COX-2 expression. Only 6 malignant tumors presented >50% of labeled cells, 18 malignant and 8 benign had an expression between 21 and 50%, 8 malignant and 3 benign tumors had an expression between 6 and 20%, 1 malignant tumor had an expression between 1 and 5%, and 5 malignant and 28 benign tumors had no expression. Malignant tumors showed higher COX-2 expression than did benign tumors, with statistically significant differences. The low levels of COX-2 may be one of the molecular reasons for the presence of expansive mass growth instead of the invasive pattern of other species, which is related to high COX-2 levels. Full article
(This article belongs to the Special Issue Animal Models in Cancer Research: Advancement and Perspectives)
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