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Veterinary Sciences
Special Issues
Research of Cardiovascular Diseases on Animal Models
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Research of Cardiovascular Diseases on Animal Models

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Biomedical Sciences".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 3914

Special Issue Editor

Dr. Amparo Ruíz-Saurí

E-Mail Website
Guest Editor
Department of Pathology, University of Valencia, 46010 Valencia, Spain
Interests: myocardial infarction; heart conduction system; morphology; histology

Special Issue Information

Dear Colleagues,

Regarding epidemiologic studies, cardiovascular disorders are considered the number one cause of morbimortality in Western countries. In fact, despite the promising advances in patient care, the incidence of cardiovascular disease continues to increase. For that reason, advancing in novel therapeutic and diagnostic tools in this field is crucial.

In order to translate the advances from basic research to the bedside, an important step is to explore, in detail, the pathophysiology of some cardiovascular diseases as well as novel diagnostic and therapeutic tools in animal models, always prioritizing animal welfare and humane treatment.

The aim of this Special Issue is to publish original research papers and reviews exploring cardiovascular diseases through animal models, acting as a bridge between bench research and clinics.

Dr. Amparo Ruíz-Saurí
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • myocardial infarction
  • arrythmias
  • heart failure
  • congenital heart disease

Published Papers (1 paper)

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Research

11 pages, 1366 KiB  
Article
Hemodynamic Effects of Protamine Infusion in Dogs with Myxomatous Mitral Valve Disease Undergoing Mitral Valvuloplasty
by Tomohiko Yoshida, Katsuhiro Matsuura, Ahmed S. Mandour, Yuki Aboshi, Shusaku Yamada, Hideki Yotsuida, Mizuki Hasegawa, Chieh-Jen Cheng, Youta Yaginuma, Momoko Watanabe and Shou Fukuzumi
Vet. Sci. 2022, 9(4), 178; https://doi.org/10.3390/vetsci9040178 - 8 Apr 2022
Cited by 3 | Viewed by 3343
Abstract
Protamine, an antagonizing agent to heparin, is indispensable for dogs undergoing cardiopulmonary bypass. Protamine-induced hypotension (PIH) during cardiac anesthesia has been reported in humans. The purpose of this study was to describe the hemodynamic effect of protamine administration in dogs during cardiac surgery [...] Read more.
Protamine, an antagonizing agent to heparin, is indispensable for dogs undergoing cardiopulmonary bypass. Protamine-induced hypotension (PIH) during cardiac anesthesia has been reported in humans. The purpose of this study was to describe the hemodynamic effect of protamine administration in dogs during cardiac surgery in clinical cases. Study design: Retrospective, clinical, cohort study. A total of 14 client-owned dogs who suffered heart failure due to medically uncontrolled myxomatous mitral valve disease (MMVD) were included in this study. The severity of MMVD was classified according to American College of Veterinary Internal Medicine staging (ACVIM: stage B2, C, D) and dogs undergoing mitral valve surgery. Records with clinical data for dogs treated between July 2019 to August 2020 were examined for age, sex, breed, body weight, concurrent diseases, hospitalization, anesthetic record, and mortality within 3 months after the operation. PIH was defined as mean arterial pressure (MAP) lowered by 20% of that before protamine infusion. To evaluate the effect of protamine on hemodynamic variables, each of the other values was compared with values at the beginning of protamine infusion. MAP decreased by 41.0 and 45.7% in two dogs (14.3%) compared with pressure before protamine infusion. Others did not show obvious alteration in hemodynamic variables. Epinephrine treatment alleviated hypotension in one dog. Another dog with systemic hypotension concomitant with elevated central venous pressure did not respond to epinephrine treatment and a reboot of extracorporeal circulation was required. Reheparinization and reinstitution of cardiopulmonary bypass successfully resuscitate the second dog. In conclusion, clinicians should alert the incidence of severe hypotension even with slow protamine infusion following canine cardiac surgery. This study also provides two effective treatments for catastrophic hypotension during protamine infusion. Full article
(This article belongs to the Special Issue Research of Cardiovascular Diseases on Animal Models)
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