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Vaccines
Special Issues
Epidemiological Studies of HPV Infection and Vaccination
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Epidemiological Studies of HPV Infection and Vaccination

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Epidemiology".

Deadline for manuscript submissions: closed (10 September 2021) | Viewed by 6813

Special Issue Editor

Dr. Masayuki Sekine

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Interests: HPV vaccine; HPV-related cancer; epidemiology; mechanisms of cancer development

Special Issue Information

Dear Colleagues,

The effectiveness of the HPV vaccine for precancerous lesions of cervical cancer has been demonstrated in many epidemiological studies, and the effect on cervical invasive cancer was also reported for the first time in the world from Sweden last October. It has been reported that persistent HPV infection increases the carcinogenic risk of vaginal/vulvar cancer, penile cancer, anal cancer, and oropharyngeal cancer; however, there are still few reports on the course of HPV infection and the efficacy of HPV vaccines at those sites. In addition, the epidemiologic profiles of type-specific HPV infection vary from region to region, and their epidemiological data are very important in predicting the efficacy of 9-valent vaccines. The understanding the profile of HPV infection will help develop new cancer screening methods. In this Special Issue, we will focus on HPV infection not only in the cervix but also in other parts of the body, and would like to provide a deeper discussion on the effectiveness of HPV vaccine.

Dr. Masayuki Sekine
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPV infection
  • HPV vaccine
  • epidemiological study
  • HPV-related cancer

Published Papers (1 paper)

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Review

14 pages, 583 KiB  
Review
Long-Term Effects of Human Papillomavirus Vaccination in Clinical Trials and Real-World Data: A Systematic Review
by Megumi Kurosawa, Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J. B. Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi and Takayuki Enomoto
Vaccines 2022, 10(2), 256; https://doi.org/10.3390/vaccines10020256 - 08 Feb 2022
Cited by 4 | Viewed by 6326
Abstract
The preventive effect of HPV vaccines against anogenital and oropharyngeal cancers has been proven in both clinical trials and real-world data. We reviewed the published evidence about the long-term efficacy and effectiveness of the HPV vaccine in available papers of clinical trials and [...] Read more.
The preventive effect of HPV vaccines against anogenital and oropharyngeal cancers has been proven in both clinical trials and real-world data. We reviewed the published evidence about the long-term efficacy and effectiveness of the HPV vaccine in available papers of clinical trials and real-world data. As far as we searched, the longest period of preventive effect for the bivalent, 4-valent, and 9-valent vaccine were 11 years in the Costa Rica trial, 14 years in the FUTURE II, and 8 years in the LTFU extension study of V503-002 and the Scandinavian study, respectively. The sustained clinical effect during the observation period was longest for the 4-valent vaccine. In real-world data, the longest observation period of the vaccine effectiveness was 12 years in an Australian study for the 4-valent vaccine. On the other hand, the longest period of long-term persistence of HPV vaccine-induced seropositivity was 14 years in FUTURE II for the 4-valent vaccine. For the bivalent vaccine, additional long-term follow-up studies may not have been planned due to the launch of the 4-valent and 9-valent vaccines. In some studies of the 9-valent vaccine, the results have not yet been published because of the short observation period. The additional results are expected in the future. In a national immunization program, most girls and boys are inoculated with HPV vaccine by the time puberty begins; thus, it is important to monitor the vaccine effect at least until the sexually active period in their 20s and 30s. Full article
(This article belongs to the Special Issue Epidemiological Studies of HPV Infection and Vaccination)
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