mRNA-Based Vaccine Development

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "DNA and mRNA Vaccines".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 3860

Special Issue Editors


E-Mail Website
Guest Editor
Vaccine Research and Development, Coalition for Epidemic Preparedness Innovations (CEPI), 0277 Oslo, Norway
Interests: mRNA vaccines; innovations; next generation vaccines; infectious diseases

E-Mail Website
Guest Editor
Vaccine Research and Development, Coalition for Epidemic Preparedness Innovations (CEPI), London NW1 2BE, UK
Interests: mRNA vaccine technologies; infectious diseases

Special Issue Information

Dear Colleagues,

The COVID-19 pandemic has had a devastating impact worldwide, causing widespread illness, loss of life, and economic hardship. However, the rapid development of mRNA technology platforms has offered a glimmer of hope in the fight against the pandemic. Two of the most widely administered vaccines against SARS-CoV-2 are based on mRNA technology, highlighting the potential of this innovative approach for preventing and controlling future epidemics and pandemics. While mRNA-based vaccines have shown promising results, there are still significant challenges including, e.g., the sub-optimal expression of antigens invivo, stability at ultra cold temperatures, higher cost of goods, etc.

Advancements in the existing mRNA technology and the fostering of innovative approaches are key to facilitating the discovery and development of improved vaccines. The scope of this topic will include original artciles related to improving mRNA replicons/constructs, finding ways to improve immunogenicity and reduce reactogenicity, investigating targeted delivery, formulation strategies, exploring alternative routes of administration, reducing vaccine development timelines and more.

Dr. Arun Kumar
Dr. Martina Ochs
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mRNA vaccines
  • mRNA delivery
  • infectious diseases
  • mRNA innovations

Published Papers (1 paper)

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Review

31 pages, 6001 KiB  
Review
In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future
by Alexey D. Perenkov, Alena D. Sergeeva, Maria V. Vedunova and Dmitri V. Krysko
Vaccines 2023, 11(10), 1600; https://doi.org/10.3390/vaccines11101600 - 16 Oct 2023
Cited by 1 | Viewed by 3397
Abstract
mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19. To improve the properties of RNA vaccines, and primarily [...] Read more.
mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19. To improve the properties of RNA vaccines, and primarily their circulation time, self-amplifying mRNA and trans-amplifying mRNA were developed. A separate branch of mRNA technology is circular RNA vaccines, which were developed with the discovery of the possibility of translation on their protein matrix. Circular RNA has several advantages over mRNA vaccines and is considered a fairly promising platform, as is trans-amplifying mRNA. This review presents an overview of the mRNA platform and a critical discussion of the more modern self-amplifying mRNA, trans-amplifying mRNA, and circular RNA platforms created on its basis. Finally, the main features, advantages, and disadvantages of each of the presented mRNA platforms are discussed. This discussion will facilitate the decision-making process in selecting the most appropriate platform for creating RNA vaccines against cancer or viral diseases. Full article
(This article belongs to the Special Issue mRNA-Based Vaccine Development)
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