Dear Colleagues,

In recent years, the world has seen improvements in kidney transplantation management and survival. 

These changes make it possible to propose transplantation to an increased pool of patients, offering the opportunity to improve the quality of life of patients with end-stage renal disease.

On the other hand, the increased number of patients potentially eligible for transplantation may represent a challenge because this group may also include fragile and old subjects and patients with significant comorbidities.

In this regard, one of the most important groups of patients potentially eligible for kidney transplantation is constituted by patients with a history of immune diseases. These may include systemic disorders, such as lupus, systemic sclerosis, or vasculitis, or primary renal diseases, such as proteinuric glomerulonephritis.

Performing kidney transplantation in these patients, especially from a living donor, may be problematic for the difficulty of general medical management and because of the risk of disease recurrence that may hamper graft survival. 

Moreover, immune-mediated diseases may also present as de novo complications after transplantation.

For these reasons, acquiring data on the pathogenesis and management of pre-existing, de novo, or recurrent immune diseases in patients undergoing kidney transplantation may have a relevant clinical impact.

For this Special Issue of Transplantology, we welcome the submission of original research papers, case reports, and review articles focused on the following topics:

• Kidney transplantation in patients with systemic immune diseases; 
• Kidney transplantation in patients with lupus;
• Kidney transplantation in patients with primary glomerular diseases;
• Living donor kidney transplantation in patients with underlying immune disease;
• Recurrent immune disease after kidney transplantation;
• De novo immune disease after kidney transplantation;
• Prophylactic strategy to prevent recurrence of immune diseases in kidney transplantation;
• Complications of kidney transplantation in patients with immune disorders;
• Pathogenesis, clinical presentation, and treatment of acute and chronic kidney graft rejection.

Dr. Pasquale Esposito
Guest Editor

Manuscript Submission Information

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• kidney transplantation
• kidney graft rejection
• immune disease