Studies of Ecology, Chemical Analysis, and Biochemical Properties of Bio-Toxins from Aquatic Organisms

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Marine and Freshwater Toxins".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 3533

Special Issue Editors


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Guest Editor
Department of Marine Resource and Biotechnology, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou, China
Interests: marine bioactive natural products; marine toxins; marine microbiota; rapid detection methods; bioactive materials; anti-allergic natural products

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Guest Editor
Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou 325035, China
Interests: cyanotoxin; microbiota; metabolites; accumulation; toxicological effects
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Interests: foodborne toxins; food allergy; innate immunity; adaptive immunity; signaling, cellular and molecular mechanisms

Special Issue Information

Dear Colleagues,

Biotoxins discovered from aquatic organisms in marine or freshwater ecosystems, such as algal toxins, shellfish toxins, palytoxin, ostreocins, etc., often lead to direct economic losses and limit the development of aquaculture, as well as seriously affecting human health and safety. Aquatic toxins can be passed on to humans through the food chain or direct contact, thus causing poisoning; additionally, the toxins themselves could become “allergens”, causing excessive immune responses.

The scope of this Special Issue includes studies on the occurrence and developmental mechanisms of biotoxins from aquatic organisms, rapid detection and characterization of the biotoxins, assessment of ecological risks, environmental fate, accumulation, and dissipation of toxins transmitted along food chain, as well as the effects on human health and safety.

Since the 20th century, shellfish poisoning incidents have been reported in many countries. About half of all unnatural deaths in marine mammals are due to of the ingestion of HABs (harmful algal blooms) or animals contaminated with them, which cause about 60,000 annual poisonings worldwide. Toxins can cause several clinically explained syndromes, characterized by a variety of symptoms, such as neurotoxic, diarrhetic, amnesic, and paralytic. In the 1970s, cholera toxin was found to modulate the immune response, and in the 1980s, some toxins were characterized as “super antigens”, which revealed that aquatic toxins may also be a risk factor for many immune diseases, e.g., food allergy.

Scholastic research on advanced science and technology may include but is not limited to bioinformatics, biogenetics, and biosynthetic mechanisms of aquatic biotoxins; the development of analytical and bioanalytical techniques for rapid detection mechanisms of biotoxins from aquatic organisms; rapid detection and characterization of biotoxins; assessment of ecological risks, environmental fate, accumulation, and dissipation of toxins transmitted along the food chain, as well as the effects on humans and characterization of biotoxins; and biological and biostatistical studies for the evaluation of ecological risks, environmental fate, and toxic and immune effects on human health and safety.

Prof. Dr. Bingnan Han
Prof. Dr. Zengling Ma
Dr. Ping Tong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aquatic/animal/botany/microbiota
  • biosynthesis
  • toxins
  • immune response
  • cofactor
  • toxin accumulation
  • metabolic pathway
  • chemical analysis
  • risk assessment

Published Papers (2 papers)

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Research

12 pages, 1788 KiB  
Article
Okadaic Acid Detection through a Rapid and Sensitive Amplified Luminescent Proximity Homogeneous Assay
by Yuan Qin, Jiayu Li, Jiani Kuang, Sicheng Shen, Xiumei Zhou, Xueqin Zhao, Biao Huang and Bingnan Han
Toxins 2023, 15(8), 501; https://doi.org/10.3390/toxins15080501 - 14 Aug 2023
Cited by 1 | Viewed by 1070
Abstract
Okadaic acid (OA), a marine biotoxin produced by microalgae, poses a significant threat to mariculture, seafood safety, and human health. The establishment of a novel, highly sensitive detection method for OA would have significant practical and scientific implications. Therefore, the purpose of this [...] Read more.
Okadaic acid (OA), a marine biotoxin produced by microalgae, poses a significant threat to mariculture, seafood safety, and human health. The establishment of a novel, highly sensitive detection method for OA would have significant practical and scientific implications. Therefore, the purpose of this study was to develop an innovative approach for OA detection. A competitive amplified luminescent proximity homogeneous assay (AlphaLISA) was developed using the principle of specific antigen–antibody binding based on the energy transfer between chemiluminescent microspheres. The method was non-washable, sensitive, and rapid, which could detect 2 × 10−2–200 ng/mL of OA within 15 min, and the detection limit was 4.55 × 10−3 ng/mL. The average intra- and inter-assay coefficients of variation were 2.54% and 6.26%, respectively. Detection of the actual sample results exhibited a good correlation with high-performance liquid chromatography. In conclusion, a simple, rapid, sensitive, and accurate AlphaLISA method was established for detecting OA and is expected to significantly contribute to marine biotoxin research. Full article
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16 pages, 3098 KiB  
Article
Discovery of a High-Efficient Algicidal Bacterium against Microcystis aeruginosa Based on Examinations toward Culture Strains and Natural Bloom Samples
by He Zhang, Yan Xie, Rongzhen Zhang, Zhongliang Zhang, Xinglong Hu, Yao Cheng, Ruozhen Geng, Zengling Ma and Renhui Li
Toxins 2023, 15(3), 220; https://doi.org/10.3390/toxins15030220 - 14 Mar 2023
Cited by 4 | Viewed by 1963
Abstract
Harmful cyanobacterial blooms occur worldwide and pose a great threat to aquatic ecosystems and public health. The application of algicidal bacteria represents an eco-friendly strategy for controlling harmful cyanobacterial blooms; thus, searching for a high efficiency of algicidal bacteria has been becoming an [...] Read more.
Harmful cyanobacterial blooms occur worldwide and pose a great threat to aquatic ecosystems and public health. The application of algicidal bacteria represents an eco-friendly strategy for controlling harmful cyanobacterial blooms; thus, searching for a high efficiency of algicidal bacteria has been becoming an important and continuous task in science. Herein, we identified a bacterial strain coded Streptomyces sp. HY with a highly algicidal activity, and investigated its algicidal efficiency and mechanism against Microcystis aeruginosa. The strain HY displayed high algicidal activity toward Microcystis aeruginosa cells, with a removal rate of 93.04% within 2 days via indirect attack. Streptomyces sp. HY also showed the ability to lyse several genera of cyanobacterial strains, including Dolichospermum, Pseudanabaena, Anabaena, and Synechocystis, whereas it showed a minor impact on the green alga Scenedesmus obliquus, demonstrating its selectivity specially for targeting cyanobacteria. Its algicidal mechanism involved damages to the photosynthesis system, morphological injury of algal cells, oxidative stress, and dysfunction of the DNA repair system. Furthermore, HY treatment reduced the expression levels of genes (mcyB and mcyD) related to microcystin biosynthesis and decreased the total content of microcystin-leucine-arginine by 79.18%. Collectively, these findings suggested that the algicidal bacteria HY is a promising candidate for harmful cyanobacterial bloom control. Full article
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