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Toxics
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Toxicity Effects of Environmental Pollutants Based on Metabolomics
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Toxicity Effects of Environmental Pollutants Based on Metabolomics

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 6939

Special Issue Editor

Dr. Ana Margarida Araújo

E-Mail Website
Guest Editor
Department of Biology, Santiago Campus, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: metabolomics; environmental sciences; toxicology; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Emerging technologies in mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) have created a new avenue of opportunity to address current gaps and challenges in the toxicity assessment of chemicals/particles with potential impact on human and environmental health. Metabolomics has proven to be a powerful tool for assessing the mode of action and toxicological effects of multiple challenging conditions, proving to be a more sensitive tool than traditional toxicological studies.

This Special Issue of Toxics will be dedicated to recent metabolomics or metabolomics branches applications (e.g., lipidomics, volatilomics, fluxomics) in the field of environmental sciences research. The topics will include the new metabolomics methods for the diversity of environmental samples, the mapping of pathways related to toxicity and, consequently, the understanding of the modes of action of environmental pollutants, in the construction of prediction models for toxicity testing and biomonitoring, in the discovery of new biomarkers for risk assessment, among others. Manuscripts that address other challenging issues in the field of environmental metabolomics, including software tools and databases for metabolite annotation or combination with other -omics, are also of interest for this Special Issue. Original research articles or review articles on these topics will be accepted and we would like to invite you to contribute to this Special Issue that will be of great value to all researchers working in this field.

Dr. Ana Margarida Araújo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • environmental pollutants
  • exposome
  • mechanisms of toxicity
  • biomarkers
  • biomonitoring
  • mass spectrometry
  • NMR
  • in vitro/in vivo

Published Papers (3 papers)

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Research

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14 pages, 1827 KiB  
Article
Influence of Soil Nutrient Toxicity and Deficiency from Three Ecuadorian Climatic Regions on the Variation of Biological, Metabolic, and Nutritional Properties of Moringa oleifera Lam.
by Raluca A. Mihai, Osmar S. Acurio Criollo, Jean P. Quishpe Nasimba, Erly J. Melo Heras, Dayana K. Galván Acaro, Pablo A. Landazuri Abarca, Larisa I. Florescu and Rodica D. Catana
Toxics 2022, 10(11), 661; https://doi.org/10.3390/toxics10110661 - 03 Nov 2022
Viewed by 2375
Abstract
Moringa oleifera Lam. contains numerous essential constituents found in all plant parts (leaves, pods, and seeds). From all its edible parts, the leaf represents an effective remedy with high potential for medicinal applications. Ecuador is part of the new promising cultivation areas for [...] Read more.
Moringa oleifera Lam. contains numerous essential constituents found in all plant parts (leaves, pods, and seeds). From all its edible parts, the leaf represents an effective remedy with high potential for medicinal applications. Ecuador is part of the new promising cultivation areas for Moringa, and therefore our study is emphasized to determine the influence of soil nutrition, toxicity (excess), and deficiency, from three main areas of this country, correlated with its climatic characteristics, on the mineral components, bioactive compounds’ synthesis, and antioxidant capacity of Moringa. Different analyses were performed in soil and especially leaf samples for phytochemical content, antioxidant activity, calcium, protein, and vitamin C determination to identify the relationship between soil nutrients, abiotic conditions, and the therapeutic potential of this species cultivated in Ecuador. The obtained values using methods such as DPPH, FRAP, and ABTS showed a high antioxidant capacity of the leaves from the Coastal Ecuadorian region, related with total phenolic compounds’ content (through the Folin–Ciocalteu method) and flavonoids in samples, with results obtained under the positive influence of high soil nutrients such as Ca, Mg, Mn, and Fe. We can conclude that M. oleifera from the coastal area of Ecuador presents the right environmental and soil conditions to positively influence its mineral and phytochemical content, making it suitable for incorporation into foods and medicines to solve the nutritional and medical problems in Ecuador and worldwide. Full article
(This article belongs to the Special Issue Toxicity Effects of Environmental Pollutants Based on Metabolomics)
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21 pages, 2444 KiB  
Article
Phenotypic and Metabolomic Characterization of 3D Lung Cell Cultures Exposed to Airborne Particulate Matter from Three Air Quality Network Stations in Catalonia
by Paula Villasclaras, Clara Jaén, Barend L. van Drooge, Joan O. Grimalt, Romà Tauler and Carmen Bedia
Toxics 2022, 10(11), 632; https://doi.org/10.3390/toxics10110632 - 22 Oct 2022
Cited by 3 | Viewed by 1752
Abstract
Air pollution constitutes an environmental problem that it is known to cause many serious adverse effects on the cardiovascular and respiratory systems. The chemical characterization of particulate matter (PM) is key for a better understanding of the associations between chemistry and toxicological effects. [...] Read more.
Air pollution constitutes an environmental problem that it is known to cause many serious adverse effects on the cardiovascular and respiratory systems. The chemical characterization of particulate matter (PM) is key for a better understanding of the associations between chemistry and toxicological effects. In this work, the chemical composition and biological effects of fifteen PM10 air filter samples from three air quality stations in Catalonia with contrasting air quality backgrounds were investigated. Three-dimensional (3D) lung cancer cell cultures were exposed to these sample extracts, and cytotoxicity, reactive oxygen species (ROS) induction, metabolomics, and lipidomics were explored. The factor analysis method Multivariate Curve Resolution–Alternating Least-Squares (MCR-ALS) was employed for an integrated interpretation of the associations between chemical composition and biological effects, which could be related to urban traffic emission, biomass burning smoke, and secondary aerosols. In this pilot study, a novel strategy combining new approach methodologies and chemometrics provided new insights into the biomolecular changes in lung cells associated with different sources of air pollution. This approach can be applied in further research on air pollution toxicity to improve our understanding of the causality between chemistry and its effects. Full article
(This article belongs to the Special Issue Toxicity Effects of Environmental Pollutants Based on Metabolomics)
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Review

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21 pages, 4159 KiB  
Review
The Panoramic View of Ecuadorian Soil Nutrients (Deficit/Toxicity) from Different Climatic Regions and Their Possible Influence on the Metabolism of Important Crops
by Raluca A. Mihai, Erly J. Melo Heras, Vanessa A. Terán Maza, Iván A. Espinoza Caiza, Eliza A. Pinto Valdiviezo and Rodica D. Catana
Toxics 2023, 11(2), 123; https://doi.org/10.3390/toxics11020123 - 26 Jan 2023
Cited by 2 | Viewed by 2071
Abstract
Soil nutrients influence all stages (reproduction, growth, and development) of a plant species’ life, and it is known that the deficit and/or toxicity of one or more nutrients has negative effects on the production of crops of commercial interest. Ecuador represents one of [...] Read more.
Soil nutrients influence all stages (reproduction, growth, and development) of a plant species’ life, and it is known that the deficit and/or toxicity of one or more nutrients has negative effects on the production of crops of commercial interest. Ecuador represents one of the “mega-diverse” countries in the world, with an agricultural sector of great importance, due to its contribution to the country’s economy. This review provides a panoramic view of soil nutrients from different climatic regions of Ecuador and revises the importance of knowledge about the possible influence of nutrients from the soil on the plant metabolism able to influence the crop resistance against pathogens or to enrich the biological characteristics of these crops. Full article
(This article belongs to the Special Issue Toxicity Effects of Environmental Pollutants Based on Metabolomics)
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