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Toxics
Special Issues
Tobacco Smoke Exposure and Related Diseases
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Tobacco Smoke Exposure and Related Diseases

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 5188

Special Issue Editors

Prof. Eun-Jung Park

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Guest Editor
East-West Medical Science Research Institute, Kyung Hee University, Yongin 17104, Korea
Interests: pulmonary disease; immunotoxicity; toxic mechanism; particles; hazard chemicals
Dr. Hyoung-Yun Han

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Guest Editor
Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Korea
Interests: pharmacology and toxicology; safety assessment; nanoparticles; regulatory toxicology

Special Issue Information

Dear Colleagues,

As is well known, tobacco or tobacco smoke is made up of more than 7000 chemicals, and dozens of carcinogens are contained in the mixture. In addition, smoking is the leading cause of chronic obstructive pulmonary disease. Although evidence for a causal relationship between smoking and these diseases has been demonstrated by many researchers, the scientific evidence is still scare. Thus, there are still significant limitations when it comes to curing these diseases. The aim of this Special Issue of Toxics, “Tobacco Smoke Exposure and Related Diseases” is to publish articles that study tobacco- or tobacco-smoke-related diseases in the pharmacological and toxicological field. The submission of hypotheses, opinions and commentaries, computational or modeling studies, and meta-analyses is also welcomed.

Prof. Eun-Jung Park
Dr. Hyoung-Yun Han
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smoking
  • tobacco additives
  • cancer
  • pulmonary disease
  • toxic mechanism
  • biomarker
  • risk assessment

Published Papers (2 papers)

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Research

17 pages, 5367 KiB  
Article
Whole Cigarette Smoke Condensates Induce Accumulation of Amyloid Beta Precursor Protein with Oxidative Stress in Murine Astrocytes
by Eun-Jung Park, Seung-Woo Jin, Hyun-Ji Lim, Hyeon-Young Kim, Min-Sung Kang and Siyoung Yang
Toxics 2021, 9(7), 150; https://doi.org/10.3390/toxics9070150 - 28 Jun 2021
Cited by 1 | Viewed by 2172
Abstract
Although cigarette smoking has been postulated to be a potential risk factor for Alzheimer’s disease (AD), the toxic mechanism is still unclear. Additionally, astrocytes have been identified as a potential target, given they play multiple roles in maintaining normal brain function. In this [...] Read more.
Although cigarette smoking has been postulated to be a potential risk factor for Alzheimer’s disease (AD), the toxic mechanism is still unclear. Additionally, astrocytes have been identified as a potential target, given they play multiple roles in maintaining normal brain function. In this study, we explored the toxic mechanism of whole cigarette smoke condensates (WCSC) using murine astrocytes. Cell proliferation, the percentage of cells in the G2/M phase, and LDH concentrations in the cell supernatants were all reduced in WCSC-treated cells. In addition, oxidative stress was induced, together with shortening of processes, structural damage of organelles, disturbances in mitochondrial function, blockage of autophagic signals, accumulation of amyloid β precursor protein, and loss of chemotactic functions. Based on these results, we hypothesize that dysfunction of astrocytes may contribute to the occurrence of cigarette-smoking-induced AD. Full article
(This article belongs to the Special Issue Tobacco Smoke Exposure and Related Diseases)
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16 pages, 1667 KiB  
Article
Development of a Method for Simultaneous Analysis of Allergenic Flavoring Agents in Cigarettes and Quantitative Risk Assessment for Consumer Safety
by Dae Yong Jang, Hyung Soo Kim, Eun Chul Pack, Ye Ji Koo, Kyung Min Lim and Dal Woong Choi
Toxics 2021, 9(4), 87; https://doi.org/10.3390/toxics9040087 - 18 Apr 2021
Cited by 3 | Viewed by 2426
Abstract
Flavoring agents are added to cigarettes to improve taste. There are mostly permitted food additives, but some of them are restricted for use in food, cosmetics, and toys, since they can cause allergic reactions. Previous studies have investigated the levels of flavoring agents [...] Read more.
Flavoring agents are added to cigarettes to improve taste. There are mostly permitted food additives, but some of them are restricted for use in food, cosmetics, and toys, since they can cause allergic reactions. Previous studies have investigated the levels of flavoring agents in tobacco but none has focused on their content in filter tips and capsules. Moreover, no studies have assessed the risk of adding allergenic flavoring agents in cigarettes. Here, we developed and validated a simultaneous analysis method for 25 allergenic flavoring agents and menthol with gas chromatography–tandem mass spectrometry to determine levels of flavoring agents in the tobacco, filter tips, and capsules of 54 commercial cigarettes in Korea. All cigarettes contained at least one allergenic flavoring agent regardless of the inclusion of flavoring capsules. Importantly, the filter tips and the capsules contained higher levels of flavoring agents than tobacco, highlighting the importance of the quantification of flavoring agents in these parts of cigarettes. Nevertheless, the risk assessment based on their levels in cigarettes suggested that their exposure was maintained at a safe level. However, the risk assessed from maximum menthol, linalool, and cinnamaldehyde exceeded one-tenth of derived no-effect levels, suggesting the need for further studies on their risk to human health. Full article
(This article belongs to the Special Issue Tobacco Smoke Exposure and Related Diseases)
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