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Toxics
Special Issues
Environmental Toxicants and Human Reproduction
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Environmental Toxicants and Human Reproduction

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 6433

Special Issue Editors

Dr. Yi-Xin Wang

E-Mail Website
Guest Editor
Harvard T.H. Chan School of Public Health, Boston, MA, USA
Interests: human reproduction; public health; epidemiology; environmental toxicants; water pollution
Dr. Liang Wang

E-Mail Website
Guest Editor
Department of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX 76798, USA
Interests: obesity; nutrition epidemiology; health education and promotion
Special Issues, Collections and Topics in MDPI journals
Dr. Cuicui Wang

E-Mail Website
Guest Editor
Harvard T.H. Chan School of Public Health, Boston, MA, USA
Interests: environmental health; epidemiology; epigenetics; aging; climate change
Prof. Dr. Qiansheng Huang

E-Mail Website
Guest Editor
1. Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China
2. Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China
Interests: microplastics; ecotoxicity; microbiota; risk assessment; data mining; toxicity mechanisms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

During the 20th century, the populations of industrialized countries all over the world experienced a decline in total fertility rates. Meanwhile, a spectacular decline in human semen quality and an increase in age-standardized infertility prevalence occurred in all parts of the world. Although genetic, socioeconomic, and psychological factors play an important role in these abovementioned changes, a growing body of toxicological and human studies have associated environmental toxicants with human reproductive health, such as reduced male semen quality and increased rates of adverse birth outcomes. However, more well-designed epidemiological studies are needed to verify the potential adverse effect of environmental toxicants on human reproductive health, practically endocrine-disrupting compounds and other emerging contaminants.

This Special Issue will comprise research articles, short communications, and reviews exploring the potential adverse effect of environmental toxicants on human reproduction. Manuscripts dedicated to emerging pollutants, endocrine-disrupting chemicals, water pollutants (e.g., disinfection byproducts), and occupational exposure are particularly welcomed. As such, with this Special Issue, we intend to collect a broad overview of the potential adverse effect of environmental exposure to several toxic chemicals (e.g., emerging pollutants, endocrine disrupting chemicals, disinfection byproducts) on human reproductive health.  

Dr. Yi-Xin Wang
Dr. Liang Wang 
Dr. Cuicui Wang
Prof. Dr. Qiansheng Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human reproduction
  • epidemiology
  • toxics
  • water pollution
  • infertility
  • emerging pollutants
  • endocrine-disrupting chemicals

Published Papers (2 papers)

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Research

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15 pages, 5072 KiB  
Article
Gestational Exposure to Cyfluthrin through Endoplasmic Reticulum (ER) Stress—Mediated PERK Signaling Pathway Impairs Placental Development
by Wensi Ni, Haoxuan Gao, Bing Wu, Ji Zhao, Jian Sun, Yanan Song, Yiping Sun and Huifang Yang
Toxics 2022, 10(12), 733; https://doi.org/10.3390/toxics10120733 - 28 Nov 2022
Cited by 3 | Viewed by 1541
Abstract
Cyfluthrin, a typical type II pyrethroid pesticide, is widely used in house hygiene and agricultural pest control. Several epidemiological investigations have found that maternal pyrethroid exposure is connected to adverse pregnancy outcomes. However, the underlying mechanisms remain to be elucidated. Thus, we evaluated [...] Read more.
Cyfluthrin, a typical type II pyrethroid pesticide, is widely used in house hygiene and agricultural pest control. Several epidemiological investigations have found that maternal pyrethroid exposure is connected to adverse pregnancy outcomes. However, the underlying mechanisms remain to be elucidated. Thus, we evaluated the effect of cyfluthrin exposure during pregnancy on placenta development in vivo. In the current study, Pregnant SD rats were randomly divided into four groups and administered 6.25, 12.5, and 25 mg/kg body weight cyfluthrin or an equivalent volume of corn oil by gavage from GD0 to GD19. The results have shown that gestational exposure to cyfluthrin exerted no effect on the fetal birth defect, survival to PND4, or fetal resorption and death. However, live fetuses and implantation sites significantly decreased in the high-dose cyfluthrin-treated group. Moreover, a significant reduction in placenta weight and diameter was observed in rats. Correspondingly, the fetal weight and crown-rump length from dams exposed to cyfluthrin were reduced. Cyfluthrin-treat groups, the total area of the placenta, spongiotrophoblast area, and labyrinth area had abnormal changes. Meanwhile, the area of blood sinusoid and CD34-positive blood vessel numbers in the placenta were considerably reduced, as well as abnormal expression of placental pro-angiogenic and anti-angiogenic factors in dams exposed to cyfluthrin. Further observation by transmission electron microscopy revealed significant changes in the ultrastructure of the medium-dose and high-dose groups. Additional experiments showed gestational exposure to cyfluthrin inhibited proliferation and induced apoptosis of placentas, as decreased PCNA-positive cells and increased TUNEL-positive cells. Furthermore, western blot and qPCR analysis revealed that gestational exposure to medium-dose and high-dose cyfluthrin increased the expression of GRP78, and three downstream mRNA and proteins (p-eIF2α, ATF4, and CHOP) of the PERK signaling, indicating that endoplasmic reticulum (ER) stress-mediated PERK/eIF2α/ATF4/CHOP signaling pathway in rat placentas was activated. Our study demonstrated that gestational exposure to cyfluthrin leads to placental developmental disorder, which might be associated with ER stress-mediated PERK signaling pathway. Full article
(This article belongs to the Special Issue Environmental Toxicants and Human Reproduction)
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Review

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29 pages, 2423 KiB  
Review
Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention
by Mahesh Rachamalla, Joshi Chinthada, Sapana Kushwaha, Sravan Kumar Putnala, Chittaranjan Sahu, Gopabandhu Jena and Som Niyogi
Toxics 2022, 10(12), 744; https://doi.org/10.3390/toxics10120744 - 30 Nov 2022
Cited by 8 | Viewed by 4487
Abstract
Arsenic (As) is a poisonous metalloid that is toxic to both humans and animals. Drinking water contamination has been linked to the development of cancer (skin, lung, urinary bladder, and liver), as well as other disorders such as diabetes and cardiovascular, gastrointestinal, neurological, [...] Read more.
Arsenic (As) is a poisonous metalloid that is toxic to both humans and animals. Drinking water contamination has been linked to the development of cancer (skin, lung, urinary bladder, and liver), as well as other disorders such as diabetes and cardiovascular, gastrointestinal, neurological, and developmental damage. According to epidemiological studies, As contributes to male infertility, sexual dysfunction, poor sperm quality, and developmental consequences such as low birth weight, spontaneous abortion, and small for gestational age (SGA). Arsenic exposure negatively affected male reproductive systems by lowering testicular and accessory organ weights, and sperm counts, increasing sperm abnormalities and causing apoptotic cell death in Leydig and Sertoli cells, which resulted in decreased testosterone synthesis. Furthermore, during male reproductive toxicity, several molecular signalling pathways, such as apoptosis, inflammation, and autophagy are involved. Phytonutrient intervention in arsenic-induced male reproductive toxicity in various species has received a lot of attention over the years. The current review provides an in-depth summary of the available literature on arsenic-induced male toxicity, as well as therapeutic approaches and future directions. Full article
(This article belongs to the Special Issue Environmental Toxicants and Human Reproduction)
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