Issues of Cancer Biology and Biomedicine with Symmetry

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Life Sciences".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 3115

Special Issue Editors


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Guest Editor
1. Department of Natural Sciences, Southeastern University, 1000 Longfellow Blvd. Lakeland, FL 33801, USA
2.Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA
Interests: anticancer agents; antivirals; Parkinson’s disease; organic synthesis; drug design
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Guest Editor
Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia
Interests: medicinal chemistry; drug discovery; bioinformatics

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Guest Editor
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
Interests: fullerenol; particulate matter; reactive oxygen species; human keratinocyte cell; antioxidant; anti-inflammation; cancer biology; biomedicine

Special Issue Information

Dear Colleagues,

Symmetry and symmetry breaking could provide an innovative pathway to a solution for problems in the field of cancer biology. The term “symmetry” in biological systems is generally used in reference to well-controlled biological processes that include cell division, movement, polarity, and development. In cancer biology, numerous biological signals such as cytokines, chemokines, and reactive species can cause a shift from symmetry to symmetry breaking, which disrupts the cellular homeostasis, triggering inflammation and associated tumorigenesis and vice versa. Thus, it would be highly desirable to better understand the role of symmetry disruption in the cycle between inflammation and cancer at both molecular and cellular levels. In particular, restoring homeostasis by targeting cell division, movement, or polarity, resolving dysregulated inflammation, and abolishing the formation of the tumor microenvironment of interest as promising directions.

In this Special Issue of Symmetry, we would like to invite contributions from all research fields, including cancer biology, chemistry, nutrition science, biomedicine, cancer-associated inflammation, antioxidant research, and any other relevant fields, regardless of the discipline. Contributions may be in the form of original research articles, reviews, or shorter perspective articles. Topics relevant to the mechanisms of anti-inflammation, anti-cancer, and anti-oxidation are all welcome.

Prof. Dr. Ralph Salvatore
Dr. Sudip Paul
Prof. I-Ta Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer biology
  • inflammation
  • antioxidant
  • biomedicine
  • nutrition science

Published Papers (1 paper)

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Review

23 pages, 1080 KiB  
Review
Biopolymer and Biomaterial Conjugated Iron Oxide Nanomaterials as Prostate Cancer Theranostic Agents: A Comprehensive Review
by Md. Abu Rayhan, Md. Sakib Hossen, Mahruba Sultana Niloy, Mozammel Haque Bhuiyan, Sudip Paul and Md. Salman Shakil
Symmetry 2021, 13(6), 974; https://doi.org/10.3390/sym13060974 - 31 May 2021
Cited by 6 | Viewed by 3100
Abstract
Prostate cancer (PCa) is the most common malignancy in men and the leading cause of death for men all over the world. Early diagnosis is the key to start treatment at an early stage of PCa and to reduce the death toll. Generally, [...] Read more.
Prostate cancer (PCa) is the most common malignancy in men and the leading cause of death for men all over the world. Early diagnosis is the key to start treatment at an early stage of PCa and to reduce the death toll. Generally, PCa expresses characteristic morphologic features and serum biomarkers; however, early diagnosis is challenging due to its heterogeneity and long-term indolent phase in the early stage. Following positive diagnosis, PCa patients receive conventional treatments including surgery, radiation therapy, androgen deprivation therapy, focal therapy, and chemotherapy to enhance survival time and alleviate PCa-related complications. However, these treatment strategies have both short and long-term side effects, notably impotence, urinary incontinence, erectile dysfunctions, and recurrence of cancer. These limitations warrant the quest for novel PCa theranostic agents with robust diagnostic and therapeutic potentials to lessen the burden of PCa-related suffering. Iron oxide nanoparticles (IONPs) have recently drawn attention for their symmetrical usage in the diagnosis and treatment of several cancer types. Here, we performed a systematic search in four popular online databases (PubMed, Google Scholar, Scopus, and Web of Science) for the articles regarding PCa and IONPs. Published literature confirmed that the surface modification of IONPs with biopolymers and diagnostic biomarkers improved the early diagnosis of PCa, even in the metastatic stage with reliable accuracy and sensitivity. Furthermore, fine-tuning of IONPs with biopolymers, nucleic acids, anticancer drugs, and bioactive compounds can improve the therapeutic efficacy of these anticancer agents against PCa. This review covers the symmetrical use of IONPs in the diagnosis and treatment of PCa, investigates their biocompatibility, and examines their potential as PCa theranostic agents. Full article
(This article belongs to the Special Issue Issues of Cancer Biology and Biomedicine with Symmetry)
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