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Smart Sensors for Biological Application

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 8664

Special Issue Editor

Centro De Investigaciones Biomédicas (CINBIO), Universidade de Vigo, 36310 Vigo, Spain
Interests: microfluidic sensing; electrochemical bio-sensing; point-of-care diagnostics; precision diagnostics; plasmonic sensing; microfluidic devices; lab-on-chip
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The sensing technology is a developing rapidly and employed in the direction of analytical application for the benefit of society. The current demand of sensing devices is not only for electronics but also for biological applications like; environmental observing, pathogen recognition, food care and disease monitoring. A Variety Of smart systems and built and introduced for a range of areas in this direction, from smart sensing to building and integration methods. Techniques reporting on the most recent knowledge advancements in multiplexed sensors and other types of smart sensor incorporated with microfluidics chips are of interest in this special issue. This includes photonic, optical, electrochemical, magnetic and other sensing strategies.

I persuade young and senior scientists to contribute in this special issue on “Smart Sensors for Biological application”, which is promising research subjects with a variety of applications. The scope of the journal is wide on sensing approaches but not limited to the specified areas:

  • Lab-on-chip systems
  • Multiplexed sensing
  • 3D printed smart sensing model system;
  • Sensor Fabrication technology for biological application;
  • Biomimetic sensing model systems;
  • Smart Photonic sensors;

Dr. Krishna Kant
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bio-Sensing
  • Microfluidic sensing
  • Smart Sensor
  • Multiplexed Sensor
  • Lab-on-chip

Published Papers (4 papers)

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Research

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22 pages, 13185 KiB  
Article
Development of a Novel, Ecologically Friendly Generation of pH-Responsive Alginate Nanosensors: Synthesis, Calibration, and Characterisation
Sensors 2023, 23(20), 8453; https://doi.org/10.3390/s23208453 - 13 Oct 2023
Viewed by 614
Abstract
Measurement of the intracellular pH is particularly crucial for the detection of numerous diseases, such as carcinomas, that are characterised by a low intracellular pH. Therefore, pH-responsive nanosensors have been developed by many researchers due to their ability to non-invasively detect minor changes [...] Read more.
Measurement of the intracellular pH is particularly crucial for the detection of numerous diseases, such as carcinomas, that are characterised by a low intracellular pH. Therefore, pH-responsive nanosensors have been developed by many researchers due to their ability to non-invasively detect minor changes in the pH of many biological systems without causing significant biological damage. However, the existing pH-sensitive nanosensors, such as the polyacrylamide, silica, and quantum dots-based nanosensors, require large quantities of organic solvents that could cause detrimental damage to the ecosystem. As a result, this research is aimed at developing a new generation of pH-responsive nanosensors comprising alginate natural polymers and pH-sensitive fluorophores using an organic, solvent-free, and ecologically friendly method. Herein, we successfully synthesised different models of pH-responsive alginate nanoparticles by varying the method of fluorophore conjugation. The synthesised pH nanosensors demonstrated a low MHD with a relatively acceptable PDI when using the lowest concentration of the cross-linker Ca+2 (1.25 mM). All the pH nanosensors showed negative zeta potential values, attributed to the free carboxylate groups surrounding the nanoparticles’ surfaces, which support the colloidal stability of the nanosensors. The synthesised models of pH nanosensors displayed a high pH-responsiveness with various correlations between the pH measurements and the nanosensors’ fluorescence signal. In summation, pH-responsive alginate nanosensors produced using organic, solvent-free, green technology could be harnessed as potential diagnostics for the intracellular and extracellular pH measurements of various biological systems. Full article
(This article belongs to the Special Issue Smart Sensors for Biological Application)
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10 pages, 2489 KiB  
Article
Pocketable Biosensor Based on Quartz-Crystal Microbalance and Its Application to DNA Detection
Sensors 2023, 23(1), 281; https://doi.org/10.3390/s23010281 - 27 Dec 2022
Cited by 1 | Viewed by 1690
Abstract
Quartz-crystal microbalance (QCM) is a technique that can measure nanogram-order masses. When a receptor is immobilized on the sensor surface of a QCM device, the device can detect chemical molecules captured by the mass change. Although QCM devices have been applied to biosensors [...] Read more.
Quartz-crystal microbalance (QCM) is a technique that can measure nanogram-order masses. When a receptor is immobilized on the sensor surface of a QCM device, the device can detect chemical molecules captured by the mass change. Although QCM devices have been applied to biosensors that detect biomolecules without labels for biomolecular interaction analysis, most highly sensitive QCM devices are benchtop devices. We considered the fabrication of an IC card-sized QCM device that is both portable and battery-powered. Its miniaturization was achieved by repurposing electronic components and film batteries from smartphones and wearable devices. To demonstrate the applicability of the card-sized QCM device as a biosensor, DNA-detection experiments were performed. The card-sized QCM device could detect specific 10-mer DNA chains while discerning single-base differences with a sensitivity similar to that of a conventional benchtop device. The card-sized QCM device can be used in laboratories and in various other fields as a mass sensor. Full article
(This article belongs to the Special Issue Smart Sensors for Biological Application)
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10 pages, 2157 KiB  
Communication
Fabrication of Beta-Barium Borate Sensing Head for Non-Invasive Measurement of Fluidic Concentration Variations
Sensors 2022, 22(24), 9566; https://doi.org/10.3390/s22249566 - 07 Dec 2022
Viewed by 864
Abstract
In this study, a beta-barium borate sensing head (BBO-SH) was fabricated and evaluated for the measurements of fluidic concentration variations by using a non-invasive technique. The BBO-SH could be coupled to a fluidic container through thin interlayer water in a heterodyne interferometer based [...] Read more.
In this study, a beta-barium borate sensing head (BBO-SH) was fabricated and evaluated for the measurements of fluidic concentration variations by using a non-invasive technique. The BBO-SH could be coupled to a fluidic container through thin interlayer water in a heterodyne interferometer based on the phase interrogation. To ensure the sensing head’s stability, the package of BBO-SH uses the prism and the coverslip bounded with UV glue, which can resist environmental damage due to moisture. After each use, the sensing head could be easily cleaned. The sensitivity of the BBO-SH remained stable after repeated measurements over a period of 139 days. Finally, the achievable measurement resolutions of the concentration and refractive index are 52 ppm and 1 × 10−6 RIU, respectively, for the sodium chloride solution. The achievable measurement resolutions of the concentration and refractive index were 55 ppm and 8.8 × 10−7 RIU, respectively, for the hydrochloric acid solution. Full article
(This article belongs to the Special Issue Smart Sensors for Biological Application)
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Review

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18 pages, 3406 KiB  
Review
Gold Nanoparticles and Plant Pathogens: An Overview and Prospective for Biosensing in Forestry
Sensors 2022, 22(3), 1259; https://doi.org/10.3390/s22031259 - 07 Feb 2022
Cited by 14 | Viewed by 4437
Abstract
Plant diseases and their diagnoses are currently one of the global challenges and causes significant impact to the economy of farmers and industries depending on plant-based products. Plant pathogens such as viruses, bacteria, fungi, and pollution caused by the nanomaterial, as well other [...] Read more.
Plant diseases and their diagnoses are currently one of the global challenges and causes significant impact to the economy of farmers and industries depending on plant-based products. Plant pathogens such as viruses, bacteria, fungi, and pollution caused by the nanomaterial, as well other important elements of pollution, are the main reason for the loss of plants in agriculture and in forest ecosystems. Presently, various techniques are used to detect pathogens in trees, which includes DNA-based techniques, as well as other microscopy based identification and detection. However, these methodologies require complex instruments and time. Lately, nanomaterial-based new biosensing systems for early detection of diseases, with specificity and sensitivity, are developed and applied. This review highlights the nanomaterial-based biosensing methods of disease detection. Precise and time effective identification of plant pathogens will help to reduce losses in agriculture and forestry. This review focuses on various plant diseases and the requirements for a reliable, fast, and cost-effective testing method, as well as new biosensing technologies for the detection of diseases of field plants in forests at early stages of their growth. Full article
(This article belongs to the Special Issue Smart Sensors for Biological Application)
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