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Microfluidic Paper-Based Chips for Detection: Current Status, Challenges and Perspectives

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Nanosensors".

Deadline for manuscript submissions: closed (1 April 2023) | Viewed by 2282

Special Issue Editor


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Guest Editor
CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
Interests: nanosensors; plasmonic materials; surface-enhanced Raman scattering-based detection; rapid detection; microfluidics; paper-based chips
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Special Issue Information

Dear Colleagues,

Microfluidic paper-based chips (μPCs) are miniature laboratory analysis systems that utilize a paper substrate for a microfluidic system instead of the traditional substrates (e.g., silicon and polymers). Due to their low cost, easy fabrication process and portability, they have been widely used in a diverse range of scientific fields, including food safety, environmental residue pollution, pathogen detection, etc. In recent years, significant research has been devoted to the study of microfluidic paper-based chips, including chip structures, sensor mechanisms, targets types, detection devices and integration systems. The rapid development in this field seen thus far indicates μPCs are swiftly gaining popularity as promising analytical platforms.  

For this particular issue, we are inviting the submission of original research papers and review articles to engender a discussion on the current status, challenges and prospects of microfluidic paper-based chips. We hope this issue will initiate a collaborative effort to encourage advancements in microfluidic technology and in solving detection and diagnosis problems. This paper will cover all aspects of microfluidic paper-based chips, including, but not limited to, the latest developments in the following areas: new μPCs design, theoretic analysis of microfluidics, hybrid sensing materials, novel sensing strategies, multiplex sensor arrays, emerging pollutants or targets and new biomarkers and other related technologies. If you are unsure whether your work falls within the scope of this Special Issue, please contact the Editor of the Special Issue before submission.

Dr. Zhiyang Zhang
Guest Editor

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Keywords

  • sensor
  • microfluidics
  • biosensor
  • microfluidics paper-based chips
  • electrochemical sesnor
  • optical detection
  • fiber material
  • flexible material
  • point-of-care diagnosis
  • portable device
  • rapid detection

Published Papers (1 paper)

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Research

11 pages, 2239 KiB  
Article
A Simple and Effective Visual Fluorescent Sensing Paper-Based Chip for the Ultrasensitive Detection of Mercury Ions in Environmental Water
by Jinglong Han, Huajun Liu, Ji Qi, Jiawen Xiang, Longwen Fu, Xiyan Sun, Liyan Wang, Xiaoyan Wang, Bowei Li and Lingxin Chen
Sensors 2023, 23(6), 3094; https://doi.org/10.3390/s23063094 - 14 Mar 2023
Cited by 2 | Viewed by 1520
Abstract
Traces of mercury ions in environmental water can harm humans and animals. Paper-based visual detection methods have been widely developed for the rapid detection of mercury ions; however, existing methods are not sensitive enough to be used in real environments. Here, we developed [...] Read more.
Traces of mercury ions in environmental water can harm humans and animals. Paper-based visual detection methods have been widely developed for the rapid detection of mercury ions; however, existing methods are not sensitive enough to be used in real environments. Here, we developed a novel, simple and effective visual fluorescent sensing paper-based chip for the ultrasensitive detection of mercury ions in environmental water. CdTe-quantum-dots-modified silica nanospheres were firmly absorbed by and anchored to the fiber interspaces on the paper’s surface to effectively avoid the unevenness caused by liquid evaporation. The fluorescence of quantum dots emitted at 525 nm can be selectively and efficiently quenched with mercury ions, and the ultrasensitive visual fluorescence sensing results attained using this principle can be captured using a smartphone camera. This method has a detection limit of 2.83 µg/L and a fast response time (90 s). We successfully achieved the trace spiking detection of seawater (from three regions), lake water, river water and tap water with recoveries in the range of 96.8–105.4% using this method. This method is effective, low-cost, user-friendly and has good prospects for commercial application. Additionally, the work is expected to be utilized in the automated big data collection of large numbers of environmental samples. Full article
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