Regulation and Control of Intracellular Signalling
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".
Deadline for manuscript submissions: closed (10 October 2022) | Viewed by 8996
Special Issue Editors
Interests: signaling transduction; neurobiochemistry; chloride homeostasis; neurodevelopmental disorders; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; drug-like molecules; pharmacology; signalling transduction
Special Issue Information
Dear Colleagues,
Almost all aspects of cellular processes and functions are dependent on intracellular signalling initiated at the cell surface. The response of cells to signalling molecules, e.g., growth factors, is determined by their complement of expressed receptors and pathways that transduce and transmit these signals to intracellular compartments; and the enzymes, ion channels/transporters, and cytoskeletal proteins that ultimately mediate the effects of the signalling molecules. Several primary classes of signalling systems either comprise ligand-gated ion channels or consist of receptor tyrosine kinases or utilise G protein-linked signals in a multistep process, operating at different time courses from milliseconds to minutes, providing great flexibility for intercellular communication. In most cases, the initial steps in the signalling system typically generate a second messenger inside the cell, and this second messenger then activates a number of proteins, including protein kinases that modify cellular processes. Intracellular signal transduction may target transcription factors that function to regulate gene expression and connect the cell surface to the nucleus, thus determining the differentiated and functional state of cells, or in response to extracellular stimuli. Abnormalities in these pathways cause many diseases, including hypertension, cancer, diabetes, neurodegeneration and inflammation, etc. Deciphering how disruptions in signalling networks lead to disease will reveal novel drug targets and improved strategies to treat these maladies.
This Special Issue on “Regulation and Control of Intracellular Signalling” aims to curate novel advances in deciphering intracellular signalling networks for drug discovery and disease treatment. Topics include but are not limited to:
- New intracellular signalling networks that are genetically and epigenetically altered in human diseases, leading to constitutive pathway activation or suppression;
- New “-omic” technologies or high-throughput methods to reveal molecular interactions in a real and quantitative way within intracellular signalling networks;
- New compounds that selectively inhibit altered proteins that are critical for the maintenance of the transformed phenotype and which have shown unprecedented clinical activity in genetically defined subsets of diseases;
- New computational approaches towards signal transduction pathways.
Dr. Jinwei Zhang
Prof. Dr. Ke Ding
Prof. Dr. Dandan Sun
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cellular processes and functions
- intracellular signalling networks
- ligand-gated ion channels
- kinases
- G protein-linked signals
- signalling transduction
- computational modelling
- drug discovery
