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Polymers
Special Issues
Water-Soluble Chitosan Derivatives-Based Materials: From Synthesis to Applications
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Water-Soluble Chitosan Derivatives-Based Materials: From Synthesis to Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3347

Special Issue Editors

Dr. Abolfazl Heydari

E-Mail Website
Guest Editor
Department for Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Dúbravská cesta 9, 845 41 Bratislava, Slovakia
Interests: cyclodextrins; bioorthogonal chemistry; polysaccharides; implantable hydrogel; supramolecular chemistry; drug delivery systems; injectable hydrogel; characterization of hydrogels
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Leire Ruiz-Rubio

E-Mail Website
Co-Guest Editor
Macromolecular Chemistry Group (LQM), Department of Physical Chemistry, University of the Basque Country, 48940 Leioa, Spain
Interests: polymer science; 3D printing; hydrogels; biomaterials; composites; photopolymerization; polysaccharides; polymer blend; thermal degradation; sensors; smart agriculture
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chitosan is a linear copolymer composed of monomeric units of 2-acetamido-2-deoxy-β-d-(+)-glucopyranose (N-acetylated glucosamine) and 2-amine-2-deoxy-β-d-glucopyranose (glucosamine), where the fraction of glucosamine unit is greater than 0.5. Chitosan is classified as a weak cationic polyelectrolyte due to the presence of ionizable primary amino groups with a pKa value of 6.4. The solubility of chitosan in an aqueous environment is dictated by the level of protonated amino groups in the glucosamine unit. Thus, chitosan is insoluble at the physiological pH of ~7.4, which represents a major inherent drawback for using chitosan in applications requiring solubility or polyelectrolyte complex formation in a neutral aqueous environment. In this regard, the chemical modification of the chitosan by introducing new functional groups to its structure, such as permanent ionic groups and carboxymethyl groups, can significantly increase the solubility of chitosan in neutral aqueous solutions. In this Special Issue, we call for papers concerning the synthesis and characterization of water-soluble chitosan derivatives, in addition to their potential applications in different areas of technology and sciences, such as pharmaceutical industries, food industries, tissue engineering, delivery systems for macromolecules, wound dressing, cosmetics, agricultural materials, water purification, drug delivery, gene therapy, and treatment of infections. New insights into the structure–property relationship of chitosan derivatives are also welcome. Thus, we invite research articles, reviews, and/or perspectives addressing and presenting water-soluble chitosan-related subjects.

Dr. Abolfazl Heydari
Dr. Leire Ruiz-Rubio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chitosan
  • water solubility
  • polyelectrolyte
  • chemical modification
  • structure–property relationship
  • characterization
  • applications
  • biomaterials

Published Papers (1 paper)

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Research

14 pages, 1893 KiB  
Article
Interleukin-12 Plasmid DNA Delivery by N-[(2-Hydroxy-3-trimethylammonium)propyl]chitosan-Based Nanoparticles
by Ali Dehshahri, Bahman Khalvati, Zahra Taheri, Farshad Safari, Reza Mohammadinejad and Abolfazl Heydari
Polymers 2022, 14(11), 2176; https://doi.org/10.3390/polym14112176 - 27 May 2022
Cited by 3 | Viewed by 2127
Abstract
Cationic polysaccharides are capable of forming polyplexes with nucleic acids and are considered promising polymeric gene carriers. The objective of this study was to evaluate the transfection efficiency and cytotoxicity of N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan salt (HTCS), a quaternary ammonium derivative of chitosan (CS), [...] Read more.
Cationic polysaccharides are capable of forming polyplexes with nucleic acids and are considered promising polymeric gene carriers. The objective of this study was to evaluate the transfection efficiency and cytotoxicity of N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan salt (HTCS), a quaternary ammonium derivative of chitosan (CS), which benefits from non-ionizable positive charges. In this work, HTCS with a full quaternization of amino groups and a molar mass of 130,000 g·mol−1 was synthesized to use for delivery of a plasmid encoding the interleukin-12 (IL-12) gene. Thus, a polyplex based on HTCS and the IL-12 plasmid was prepared and then was characterized in terms of particle size, zeta potential, plasmid condensation ability, and protection of the plasmid against enzymatic degradation. We showed that HTCS was able to condense the IL-12 plasmid by the formation of polyplexes in the range of 74.5 ± 0.75 nm. The level of hIL-12 production following the transfection of the cells with HTCS polyplexes at a C/P ratio of 8:1 was around 4.8- and 2.2-fold higher than with CS and polyethylenimine polyplexes, respectively. These findings highlight the role of HTCS in the formation of polyplexes for the efficient delivery of plasmid DNA. Full article
(This article belongs to the Special Issue Water-Soluble Chitosan Derivatives-Based Materials: From Synthesis to Applications)
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