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Polymers
Special Issues
Translation of Polymeric Biomaterials: From the Lab to the Clinic
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Translation of Polymeric Biomaterials: From the Lab to the Clinic

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (20 July 2021) | Viewed by 7717

Special Issue Editors

Prof. Dr. Abraham Joy

E-Mail Website
Guest Editor
Department of Polymer Science, The University of Akron, Akron, OH, USA
Interests: wound healing; protein delivery; antibiofilm/antibacterial polymers; tissue-mimetic soft and elastic scaffolds
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Brian D. Polizzotti

E-Mail Website
Guest Editor
Department of Cardiology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Interests: intravenous oxygen delivery; polymeric volume expanders; bubble-based acoustic pressure sensors; biomaterials to target and reverse tissue hypoxia

Special Issue Information

Dear Colleagues,

For the past 60 years, natural and synthetic biomaterials have been used to repair, supplement or replace tissues. During this period, significant advances have been made in the design, fabrication, and interfacing of biomaterials with cells and tissues. The first step in impacting clinical practice with novel biomaterials is the recognition of an unmet clinical need, followed by the bottom–up design of materials that are able to overcome the translational challenges of biomaterial synthesis, fabrication, and adaptability for the specific clinical need. In addition, regulatory aspects and market forces need to be considered. In this Special Issue, we are looking for articles that illustrate these challenges of biomaterials design with specific examples of clinical need. The authors are encouraged to explain the clinical need and illustrate their design of biomaterials for these clinical needs. The focus of the article can span the breadth of biomaterials science, including synthesis, characterization, fabrication or encapsulation of therapeutics or cells.

We look forward to your exciting contributions.

Prof. Dr. Abraham Joy
Prof. Dr. Brian D. Polizzotti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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15 pages, 2651 KiB  
Article
Antimicrobial Hexaaquacopper(II) Complexes with Novel Polyiodide Chains
by Zehra Edis, Radhika Raheja, Samir Haj Bloukh, Richie R. Bhandare, Hamid Abu Sara and Guido J. Reiss
Polymers 2021, 13(7), 1005; https://doi.org/10.3390/polym13071005 - 24 Mar 2021
Cited by 7 | Viewed by 1941
Abstract
The non-toxic inorganic antimicrobial agents iodine (I2) and copper (Cu) are interesting alternatives for biocidal applications. Iodine is broad-spectrum antimicrobial agent but its use is overshadowed by compound instability, uncontrolled iodine release and short-term effectiveness. These disadvantages can be reduced by [...] Read more.
The non-toxic inorganic antimicrobial agents iodine (I2) and copper (Cu) are interesting alternatives for biocidal applications. Iodine is broad-spectrum antimicrobial agent but its use is overshadowed by compound instability, uncontrolled iodine release and short-term effectiveness. These disadvantages can be reduced by forming complex-stabilized, polymeric polyiodides. In a facile, in-vitro synthesis we prepared the copper-pentaiodide complex [Cu(H2O)6(12-crown-4)5]I6 · 2I2, investigated its structure and antimicrobial properties. The chemical structure of the compound has been verified. We used agar well and disc-diffusion method assays against nine microbial reference strains in comparison to common antibiotics. The stable complex revealed excellent inhibition zones against C. albicans WDCM 00054, and strong antibacterial activities against several pathogens. [Cu(H2O)6(12-crown-4)5]I6 · 2I2 is a strong antimicrobial agent with an interesting crystal structure consisting of complexes located on an inversion center and surrounded by six 12-crown-4 molecules forming a cationic substructure. The six 12-crown-4 molecules form hydrogen bonds with the central Cu(H2O)6. The anionic substructure is a halogen bonded polymer which is formed by formal I5− repetition units. The topology of this chain-type polyiodide is unique. The I5− repetition units can be understood as a triodide anion connected to two iodine molecules. Full article
(This article belongs to the Special Issue Translation of Polymeric Biomaterials: From the Lab to the Clinic)
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Review

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62 pages, 3523 KiB  
Review
Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research
by Manisha Pandey, Hira Choudhury, Azila binti Abd Aziz, Subrat Kumar Bhattamisra, Bapi Gorain, Jocelyn Sziou Ting Su, Choo Leey Tan, Woon Yee Chin and Khar Yee Yip
Polymers 2021, 13(8), 1340; https://doi.org/10.3390/polym13081340 - 20 Apr 2021
Cited by 35 | Viewed by 5196
Abstract
Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes [...] Read more.
Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders. Full article
(This article belongs to the Special Issue Translation of Polymeric Biomaterials: From the Lab to the Clinic)
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