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Polymers
Special Issues
Polymer Issues in Orthopaedic Implants
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Polymer Issues in Orthopaedic Implants

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (15 September 2020) | Viewed by 7836

Special Issue Editor

Prof. Dr. Cheng-Kung Cheng

E-Mail Website
Guest Editor
Department of Biomedical Engineering, National Yang-Ming University, Taipei 11221, Taiwan
Interests: biomedical engineering; orthopaedic biomechanics; design and analysis of orthopaedic implants; rehabilitation science and technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There are many issues related to absorbable and non-absorbable polymer implants in orthopaedic applications. Typical issues on wear particles caused by bone osteolysis have been paid special attention in the past few decades, especially on the UHMWPE used in orthopaedic joint reconstruction implants. Another typical application is in resorbable implants for fixation. The low strength level required to induce implant instability and an uncontrolled degradation rate leading to implant failure and adverse infection has been a dilemma for orthopaedic applications for many years. This Special Issue would like to invite researchers to address these two big issues and try to contribute to the orthopaedic industry to solve the implant development issues on these very interesting and important topics.

Prof. Dr. Cheng-Kung Cheng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Orthopaedic implant
  • UHMWPE
  • Bioabsorbable polymer
  • Osteolysis
  • Degradation rate
  • Strength, fixation, and stability

Published Papers (1 paper)

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Research

18 pages, 6978 KiB  
Article
Polyethylene-Based Knee Spacer for Infection Control: Design Concept and Pre-Clinical In Vitro Validations
by Yuhan Chang, Mel S. Lee, Jiann-Jong Liau, Yu-Liang Liu, Wen-Chuan Chen and Steve W. N. Ueng
Polymers 2020, 12(10), 2334; https://doi.org/10.3390/polym12102334 - 13 Oct 2020
Cited by 4 | Viewed by 7340
Abstract
Antibiotic-loaded polymethyl methacrylate (PMMA) has been widely applied in the treatment of knee periprosthetic joint infections. However, problems with antibiotic-loaded PMMA-based spacers, such as structural fracture and implant dislocation, remain unresolved. A novel polyethylene-based spacer, designed with an ultra-congruent articulating surface and multiple [...] Read more.
Antibiotic-loaded polymethyl methacrylate (PMMA) has been widely applied in the treatment of knee periprosthetic joint infections. However, problems with antibiotic-loaded PMMA-based spacers, such as structural fracture and implant dislocation, remain unresolved. A novel polyethylene-based spacer, designed with an ultra-congruent articulating surface and multiple fenestrations, was introduced in the current study. Validation tests for biomechanical safety, wear performance, and efficacy of antibiotic cement were reported. During cycle fatigue testing, no tibial spacer failures were observed, and less wear debris generation was reported compared to commercial PMMA-based spacers. The volumetric wear of the novel spacer was within the safety threshold for osteolysis-free volumetric wear. An effective infection control was demonstrated despite the application of lesser antibiotic cement in the 30-day antibiotic elution test. The tube dilution test confirmed adequate inhibitory capabilities against pathogens with the loaded antibiotic option utilized in the current study. The novel polyethylene-based knee spacer may offer sufficient biomechanical safety and serve as an adequate carrier of antibiotic-loaded cement for infection control. Further clinical trials shall be conducted for more comprehensive validation of the novel spacer for practical application. Full article
(This article belongs to the Special Issue Polymer Issues in Orthopaedic Implants)
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