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Polymers
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Natural Polymer-Based Drug Delivery Complexes against Microorganisms
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Natural Polymer-Based Drug Delivery Complexes against Microorganisms

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: closed (1 April 2023) | Viewed by 8176

Special Issue Editor

Dr. Vinit Raj

E-Mail Website
Guest Editor
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea
Interests: biomaterial; nanocarriers; polymers; antibiotic resistance; the effects of natural or synthetic molecules on fungi and bacteria; Staphylococcus aureus; Candida albicans
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nano-drug delivery has been established and developed as an alternative technique to improve the effectiveness of antifungals and antibiotics against biofilms. The effective penetration capabilities of nanocarriers (NCs) inside the biofilm can help improve the drug potency for treating several diseases, including biofilm-associated bacterial, and fungal infections. Natural biological molecules are currently being discovered for their antibiofilm potencies to develop effective drug molecules for the treatment of biofilm-associated human infection.

Dr. Vinit Raj
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanocarriers
  • antimicrobial
  • biofilm
  • polymers
  • antibiotic

Published Papers (3 papers)

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Research

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14 pages, 2804 KiB  
Article
Thermo-Sensitive Poly (N-isopropylacrylamide-co-polyacrylamide) Hydrogel for pH-Responsive Therapeutic Delivery
by Madhappan Santhamoorthy, Thi Tuong Vy Phan, Vanaraj Ramkumar, Chaitany Jayprakash Raorane, Kokila Thirupathi and Seong-Cheol Kim
Polymers 2022, 14(19), 4128; https://doi.org/10.3390/polym14194128 - 2 Oct 2022
Cited by 24 | Viewed by 3122
Abstract
Stimuli-response polymeric nanoparticles have emerged as a carrier system for various types of therapeutic delivery. In this study, we prepared a dual pH- and thermo-sensitive copolymer hydrogel (HG) system (PNIPAm-co-PAAm HG), using N-isopropyl acrylamide (NIPAm) and acrylamide (AAm) as comonomers. The synthesized PNIPAm-co-PAAm [...] Read more.
Stimuli-response polymeric nanoparticles have emerged as a carrier system for various types of therapeutic delivery. In this study, we prepared a dual pH- and thermo-sensitive copolymer hydrogel (HG) system (PNIPAm-co-PAAm HG), using N-isopropyl acrylamide (NIPAm) and acrylamide (AAm) as comonomers. The synthesized PNIPAm-co-PAAm HG was characterized using various instrumental characterizations. Moreover, the PNIPAm-co-PAAm HG’s thermoresponsive phase transition behavior was investigated, and the results showed that the prepared HG responds to temperature changes. In vitro drug loading and release behavior of PNIPAm-co-PAAm HG was investigated using Curcumin (Cur) as the model cargo under different pH and temperature conditions. The PNIPAm-co-PAAm HG showed pH and temperature-responsive drug release behavior and demonstrated about 65% Cur loading efficiency. A nearly complete release of the loaded Cur occurred from the PNIPAm-co-PAAm HG over 4 h at pH 5.5 and 40 °C. The cytotoxicity study was performed on a liver cancer cell line (HepG2 cells), which revealed that the prepared PNIPAm-co-PAAm HG showed good biocompatibility, suggesting that it could be applied as a drug delivery carrier. Moreover, the in vitro cytocompatibility test (MTT assay) results revealed that the PNIPAm-co-PAAm HG is biocompatible. Therefore, the PNIPAm-co-PAAm HG has the potential to be useful in the delivery of drugs in solid tumor-targeted therapy. Full article
(This article belongs to the Special Issue Natural Polymer-Based Drug Delivery Complexes against Microorganisms)
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Review

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12 pages, 2651 KiB  
Review
Novel Approach in Biodegradation of Synthetic Thermoplastic Polymers: An Overview
by Raja Venkatesan, Madhappan Santhamoorthy, Krishnapandi Alagumalai, Rajesh Haldhar, Chaitany Jayprakash Raorane, Vinit Raj and Seong-Cheol Kim
Polymers 2022, 14(20), 4271; https://doi.org/10.3390/polym14204271 - 12 Oct 2022
Cited by 7 | Viewed by 2289
Abstract
Biodegradation is necessary for water-soluble or water-immiscible polymers because they eventually enter streams which can neither be recycled nor incinerated. It is important to consider the microbial degradation of natural and synthetic polymers in order to understand what is necessary for biodegradation and [...] Read more.
Biodegradation is necessary for water-soluble or water-immiscible polymers because they eventually enter streams which can neither be recycled nor incinerated. It is important to consider the microbial degradation of natural and synthetic polymers in order to understand what is necessary for biodegradation and the mechanisms involved. Low/high-density polyethylene is a vital cause of environmental pollution. It occurs by choking the sewer line through mishandling, thus posing an everlasting ecological threat. Environmental pollution due to the unscrupulous consumption of synthetic polymers derived from petroleum has an adverse impact on the environment since the majority of plastics do not degrade, and the further incineration of synthetic plastics generates CO2 and dioxin. This requires understanding the interactions between materials and microorganisms and the biochemical changes involved. Widespread studies on the biodegradation of plastics have been carried out in order to overcome the environmental problems associated with synthetic plastic waste. Awareness of the waste problem and its impact on the environment has awakened new interest in the area of degradable polymers through microbes viz., bacteria, fungi, and actinomycetes. The microbial degradation of plastics is caused by certain enzymatic activities that lead to a chain cleavage of polymers into oligomers and monomers. This review focuses on the biodegradation rate of plastics by fungal and bacterial communities and the mode of action of biodegradation. Full article
(This article belongs to the Special Issue Natural Polymer-Based Drug Delivery Complexes against Microorganisms)
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24 pages, 3246 KiB  
Review
Recent Progress on Modified Gum Katira Polysaccharides and Their Various Potential Applications
by Mahendra Singh, Chaitany Jayprakash Raorane, Alka, Divya Shastri, Vinit Raj, Seong-Cheol Kim and Minkal Tuteja
Polymers 2022, 14(17), 3648; https://doi.org/10.3390/polym14173648 - 2 Sep 2022
Cited by 8 | Viewed by 2319
Abstract
Gum katira polysaccharide is biocompatible and non-toxic, and has antioxidant, anti-microbial, and immunomodulatory properties. It is a natural polysaccharide and exudate derived from the stem bark of Cochlospermum reliogosum Linn. Additionally, it has many traditional medicinal uses as a sedative and for the [...] Read more.
Gum katira polysaccharide is biocompatible and non-toxic, and has antioxidant, anti-microbial, and immunomodulatory properties. It is a natural polysaccharide and exudate derived from the stem bark of Cochlospermum reliogosum Linn. Additionally, it has many traditional medicinal uses as a sedative and for the treatment of jaundice, gonorrhea, syphilis, and stomach ailments. This article provides an overview of gum katira, including its extraction, separation, purification, and physiochemical properties and details of its characterization and pharmacognostic features. This paper takes an in-depth look at the synthetic methods used to modify gum katira, such as carboxymethylation and grafting triggered by free radicals. Furthermore, this review provides an overview of its industrial and phytopharmacological applications for drug delivery and heavy metal and dye removal, its biological activities, its use in food, and the potential use of gum katira derivatives and their industrial applications. We believe researchers will find this paper useful for developing techniques to modify gum katira polysaccharides to meet future demands. Full article
(This article belongs to the Special Issue Natural Polymer-Based Drug Delivery Complexes against Microorganisms)
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