Collagen-Based Materials

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 15216

Special Issue Editors


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Guest Editor
FILK Freiberg institute, Meissner Ring 1-5, 09599 Freiberg, Germany
Interests: collagen materials, engineering and characterization
FILK Freiberg Institutes, Meissner Ring 1-5, 09599 Freiberg, Germany
Interests: cell-collagen interactions; tissue engineering; regenerative medicine; additive manufacturing

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Co-Guest Editor
FILK Freiberg Institutes, Meissner Ring 1-5, 09599 Freiberg, Germany
Interests: collagen recovery, processing and analytics; collagen like peptides

Special Issue Information

Dear Colleagues,

Collagen is the most important structural protein in human and animal organisms. It is a major component of the extracellular matrix (ECM) and provides a stable scaffold for all kinds of tissue, e.g., skin, tendon, cartilage, bone, blood vessels, and organs. Due to its high biocompatibiliy and low immunogenity, collagen is frequently used as a basic material for medical devices, such as wound dressings, implants for soft and hard tissue replacement, scaffolds for tissue engineering, or carriers in drug delivery. In medical applications, collagen is not only a convenient cell substrate but is also actively recognized by cells via receptors (e.g., integrins), which leads to enhanced adhesion, proliferation, migration or differenciation of cells. Thus, collagen contributes to healing processes such as hemostasis and tissue regeneration. The chemical and molecular basis which underlies these effects is not yet completely understood and still causes intensive research, including studies on collagen chemistry and structure as well as the mechanisms of cell–collagen interaction. Furthermore, processing of collagen is still an important topic today, starting with the recovery from animal sources (bovine, porcine or equine tissues) and the preparation of collagen solutions, dispersions or powders, to the production of collageneous products for medical and pharmaceutical applications. In this field, the focus is recently shifting from pure collagen preparations to the whole extracellular matrix, including, aside from collagen, other proteins (elastin, fibrillin), proteoglycans, and glycosaminoglycans. A steadily growing number of analytical methods (physical, chemical, mechanical, and biological) accompanies the development of new processes and products and increases our knowledge of this fascinating protein.

Although thoroughly investigated for decades in different aspects, there are still many secrets linked to collagen that have yet to be uncovered and require further investigation. This Special Issue on “Collagen Materials” aims at the compilation of recent results in collagen research, covering all aspects of collagen as a protein and biopolymer with versatile properties and application potential. We invite the submission of original research papers and reviews on topics such as chemical or structural features of collagen, interactions with cells and other ECM components, collagen production and processing, and medical or other applications and analytics.

Dr. Michael Meyer
Dr. Enno Klüver
Dr. Ina Prade
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • collagen structure and modeling
  • collagen in regenerative medicine
  • synthetic collagen
  • collagen analysis
  • collagen processing
  • collagen peptides and metabolism
  • cell–collagen interactions

Published Papers (3 papers)

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Research

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11 pages, 16519 KiB  
Article
Additive Manufacturing with Thermoplastic Collagen
by Enno Klüver, Marit Baltzer, Axel Langer and Michael Meyer
Polymers 2022, 14(5), 974; https://doi.org/10.3390/polym14050974 - 28 Feb 2022
Cited by 7 | Viewed by 1815
Abstract
Thermoplastic collagen is a partially denatured collagen powder which can be processed by thermoplastic methods such as extrusion and injection molding, but was hitherto not adapted for the use in additive manufacturing (AM) techniques. This paper describes the first successful application of collagen/water/glycerol [...] Read more.
Thermoplastic collagen is a partially denatured collagen powder which can be processed by thermoplastic methods such as extrusion and injection molding, but was hitherto not adapted for the use in additive manufacturing (AM) techniques. This paper describes the first successful application of collagen/water/glycerol mixtures in an AM process using a BioScaffolder 3.2 from GeSiM mbH. Strands of molten collagen were deposited onto a building platform forming differently shaped objects. The collagen melt was characterized rheologically and optimal processing conditions were established. The technique includes the use of supporting structures of PLA/wood composite for samples with complex geometry as well as post-processing steps such as the removal of the supporting structure and manual surface smoothing. The manufactured objects are characterized concerning water solubility, swelling behavior and compressibility. Possible applications are in the non-medical sector and include collagen-based pet food or customized organ models for medical training. Full article
(This article belongs to the Special Issue Collagen-Based Materials)
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Review

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21 pages, 1390 KiB  
Review
Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications
by Zintle Mbese, Sibusiso Alven and Blessing Atim Aderibigbe
Polymers 2021, 13(24), 4368; https://doi.org/10.3390/polym13244368 - 13 Dec 2021
Cited by 51 | Viewed by 6150
Abstract
Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, [...] Read more.
Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, despite the availability of various types of wound dressing scaffolds in the market. Some of the wound dressings that are in clinical practice have various drawbacks such as poor antibacterial and antioxidant efficacy, poor mechanical properties, inability to absorb excess wound exudates, require frequent change of dressing and fails to offer a suitable moist environment to accelerate the wound healing process. Collagen is a biopolymer and a major constituent of the extracellular matrix (ECM), making it an interesting polymer for the development of wound dressings. Collagen-based nanofibers have demonstrated interesting properties that are advantageous both in the arena of skin regeneration and wound dressings, such as low antigenicity, good biocompatibility, hemostatic properties, capability to promote cellular proliferation and adhesion, and non-toxicity. Hence, this review will discuss the outcomes of collagen-based nanofibers reported from the series of preclinical trials of skin regeneration and wound healing. Full article
(This article belongs to the Special Issue Collagen-Based Materials)
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26 pages, 5492 KiB  
Review
An Overview on Collagen and Gelatin-Based Cryogels: Fabrication, Classification, Properties and Biomedical Applications
by Yujing He, Chunhua Wang, Chenzhi Wang, Yuanhang Xiao and Wei Lin
Polymers 2021, 13(14), 2299; https://doi.org/10.3390/polym13142299 - 14 Jul 2021
Cited by 36 | Viewed by 6100
Abstract
Decades of research into cryogels have resulted in the development of many types of cryogels for various applications. Collagen and gelatin possess nontoxicity, intrinsic gel-forming ability and physicochemical properties, and excellent biocompatibility and biodegradability, making them very desirable candidates for the fabrication of [...] Read more.
Decades of research into cryogels have resulted in the development of many types of cryogels for various applications. Collagen and gelatin possess nontoxicity, intrinsic gel-forming ability and physicochemical properties, and excellent biocompatibility and biodegradability, making them very desirable candidates for the fabrication of cryogels. Collagen-based cryogels (CBCs) and gelatin-based cryogels (GBCs) have been successfully applied as three-dimensional substrates for cell culture and have shown promise for biomedical use. A key point in the development of CBCs and GBCs is the quantitative and precise characterization of their properties and their correlation with preparation process and parameters, enabling these cryogels to be tuned to match engineering requirements. Great efforts have been devoted to fabricating these types of cryogels and exploring their potential biomedical application. However, to the best of our knowledge, no comprehensive overviews focused on CBCs and GBCs have been reported currently. In this review, we attempt to provide insight into the recent advances on such kinds of cryogels, including their fabrication methods and structural properties, as well as potential biomedical applications. Full article
(This article belongs to the Special Issue Collagen-Based Materials)
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