Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.6
5.0
Journals
Polymers
Special Issues
Stimuli-Responsive Polymeric Nanosystems
share announcement

Stimuli-Responsive Polymeric Nanosystems

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 5544

Special Issue Editors

Dr. Binh Thanh Mai

E-Mail Website
Guest Editor
Nanomaterials for Biomedical Applications, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genoa, Italy
Interests: polymer chemistry; drug delivery; block copolymers; self-assembly; nanoparticles
Dr. Eduardo Ruiz-Hernandez

E-Mail Website
Guest Editor
School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland
Interests: porous nanoparticles; hydrogels; triggered drug release; nanotheranostics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Kwon Taek Lim

E-Mail Website
Guest Editor
Major of Display Semiconductor Engineering, Pukyong National University, Busan, Republic of Korea
Interests: polymer chemistry; polymeric micelles; hydrogels; block copolymers; drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Nisarg Soni

E-Mail Website
Guest Editor
Nanomaterials for Biomedical Applications, Italian Institute of Technology, via Morego 30, 16163 Genoa, Italy
Interests: nanomedicine; radiochemistry; theranostics; molecular imaging; targeted therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymers are indispensable materials in every sector of daily life. Since the landmark paper of Herman Staudinger one century ago, polymers have been a very rapidly growing topic in the research and technology community. During the last few decades, polymers have been intensively studied in nanotechnology for a wide range of applications. The impact of polymers in nanotechnology includes, but is not limited to, surface modifications of nanoparticles, polymer self-assembled nanostructures and nanolithography. In particular, polymeric nanosystems featuring the capability of responding to different stimuli have been a very active research field in the last 20 years. Thanks to the advancement of nanochemistry, polymer chemistry and nanofabrication techniques, many stimuli-responsive nanosystems showing response to different stimuli such as temperature, pH, redox level, enzymes, magnetic field, light, ultrasound and electrical potentials have been developed. These nanosystems feature unprecedented properties and have been proposed for several applications including drug delivery, sensing, advanced cancer therapies, biomedical devices and smart surfaces. In this Special Issue, we aim to gather original research, communications and review papers on the synthesis, characterization and applications of stimuli-responsive nanosystems having polymer components. We are welcoming all cross-disciplinary research in which novel stimuli-responsive polymeric nanosystems are involved.

Prof. Dr. Kwon Taek Lim
Dr. Eduardo Ruiz-Hernandez
Dr. Nisarg Soni
Dr. Binh Mai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stimuli-responsive
  • smart polymers
  • nanoparticles
  • nanosystems
  • theranostic
  • therapies
  • sensing
  • drug delivery
  • biomedical applications

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

14 pages, 5660 KiB  
Article
Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release
by Dandan Xia, Feilong Wang, Shuo Pan, Shenpo Yuan, Yunsong Liu and Yongxiang Xu
Polymers 2021, 13(21), 3785; https://doi.org/10.3390/polym13213785 - 31 Oct 2021
Cited by 18 | Viewed by 2803
Abstract
Biodegradable nanoparticles and micelles are promising nanosystems for the targeted delivery of potent anticancer drugs. By using specialized polymers as nanocarriers, targeted drug delivery and release can be developed. We developed thiol-hyaluronic acid (HA-SH)/chitosan (CS) nanoparticles with redox/pH dual-responsiveness via electrostatic self-assembly followed [...] Read more.
Biodegradable nanoparticles and micelles are promising nanosystems for the targeted delivery of potent anticancer drugs. By using specialized polymers as nanocarriers, targeted drug delivery and release can be developed. We developed thiol-hyaluronic acid (HA-SH)/chitosan (CS) nanoparticles with redox/pH dual-responsiveness via electrostatic self-assembly followed by spontaneous chemical cross-linking. The nanoparticle surface charges were reversible through different HA-SH and CS mass ratios. Doxorubicin (DOX) was used as a model drug. Dual cross-linked nanoparticles with diameters of approximately 300 nm exhibited superior stability under physiological conditions compared with nanoparticles without disulfide cross-linking. DOX was loaded more efficiently into negative nanoparticles (45.7 wt%) than positive nanoparticles (14.2 wt%). Drug release from negative nanoparticles (ζ potential of approximately −20) was higher (87.8 wt%) at pH 4.5 and in the presence of 10 mM glutathione. Positive nanoparticles (ζ potential of approximately +20) showed the same trend, but the release rate was slower than that of negative nanoparticles. DOX-loaded HA-SH/CS particles were taken up by human breast cancer cells (SKBR3), and the loaded drug was released, exhibiting potential antitumor efficacy. The HA-SH/CS nanoparticles in this study were stable under physiological conditions and are promising candidates for the targeted delivery and release of anticancer drugs. Full article
(This article belongs to the Special Issue Stimuli-Responsive Polymeric Nanosystems)
►▼ Show Figures

Figure 1

15 pages, 5150 KiB  
Article
Microencapsulation of Photochromic Solution with Polyurea by Interfacial Polymerization
by Yuhua Zhang, Xi Zhang, Yurong Yan and Zhonghua Chen
Polymers 2021, 13(18), 3049; https://doi.org/10.3390/polym13183049 - 09 Sep 2021
Cited by 5 | Viewed by 2080
Abstract
Photochromic materials are interesting materials because of their color-changing property under UV light and visible light irradiation. However, they are vulnerable to many factors, such as pH oxygen, ion, solvent, etc. because of the unsaturated bonds existing on the photochromic molecular. Microencapsulation of [...] Read more.
Photochromic materials are interesting materials because of their color-changing property under UV light and visible light irradiation. However, they are vulnerable to many factors, such as pH oxygen, ion, solvent, etc. because of the unsaturated bonds existing on the photochromic molecular. Microencapsulation of the photochromic materials can separate them from the surroundings. Here, photochromic microcapsules using 3,3-Diphenyl-3H-naphtho[2,1-b] pyran (NP)/solution as core and polyurea as shell via interfacial polymerization were prepared, and bis(2,2,6,6-tetramethyl-4-piperidinyl)sebacate (HALS 770) was used as photostabilizer. Fourier transform infrared spectroscopy (FTIR), a laser particle size analyzer, a scanning electron microscope (SEM), a thermogravimetric analyzer and an ultraviolet-visible spectrophotometer were used for characterization. The results showed that the microcapsules had a uniform particle size of about 0.56 μm when the percentage of the oil phase (core) in the emulsion was less than 15%, the addition amount of the emulsifier was 0.4%, and the stirring rate was 1800 r/min. The microcapsules showed better performance in thermal stability when the core/shell ratio was 1:1. The photostabilizer had little impact on the color-changing property of the microcapsule, but it could protect the microcapsules from UV light radiation aging. Full article
(This article belongs to the Special Issue Stimuli-Responsive Polymeric Nanosystems)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop