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Polymers
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Polymer Materials for Biomedical Applications
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Polymer Materials for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (25 November 2023) | Viewed by 4012

Special Issue Editor

Prof. Dr. Shuai Jiang

E-Mail Website
Guest Editor
School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China
Interests: nanomedicine; drug delivery; targeting; bio-nano interactions; protein corona

Special Issue Information

Dear Colleagues, 

Polymer materials, including natural source and synthetic polymers, have good biocompatibility and biodegradability and facile synthesis and processing properties. Hence, they have been widely applied for various biomedical purposes. For example, they are processed as nano-sized carriers for drug loading and targeted delivery. They are also engineered as scaffolds for tissue engineering and regenerative medicine. Polymer materials (e.g., hydrogels and electrospun membranes) are also excellent dressing materials for accelerating wound healing. Moreover, injectable hydrogel materials have recently been emerging for anti-tumor and arthritis-related therapies. In this Special Issue, we welcome the submission of original research, review, mini review, and perspective articles. This topic covers but is not limited to the following themes:

  • Synthesis, functionalization, and characterization of polymer materials for biomedical applications;
  • Modification and application of natural polymers;
  • Novel applications of polymer materials for biomedical purpose;
  • Recent progress and future perspectives of polymers for biomedical applications.

Best regards,
Dr. Shuai Jiang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

12 pages, 2668 KiB  
Article
The Toughness-Enhanced Atelocollagen Double-Network Gel for Biomaterials
by Atsushi Tsuyukubo, Riku Kubota, Yuzo Sato and Ichiro Fujimoto
Polymers 2024, 16(2), 283; https://doi.org/10.3390/polym16020283 - 19 Jan 2024
Viewed by 887
Abstract
A tough gel composed of atelocollagen, which lacks an immunogenetic site, is a promising material for biomedical application. In this study, we created a composite hydrogel composed of atelocollagen gel cross-linked with glutaraldehyde (GA) and poly-(N,N-dimethylacrylamide) gel exhibiting biocompatibility [...] Read more.
A tough gel composed of atelocollagen, which lacks an immunogenetic site, is a promising material for biomedical application. In this study, we created a composite hydrogel composed of atelocollagen gel cross-linked with glutaraldehyde (GA) and poly-(N,N-dimethylacrylamide) gel exhibiting biocompatibility based on the double-network (DN) gel principle. The tensile toughness of atelocollagen gel remained constant regardless of the amount of cross-linker (GA) used. In contrast, tensile tests of the DN gel indicated that mechanical properties, such as fracture stress and toughness, were significantly higher than those of the atelocollagen gel. Moreover, fibroblast cells adhered and spread on the gels, the Schiff bases of which were treated via reductive amination for detoxification from GA. These findings demonstrate the potential of the proposed gel materials as artificial alternative materials to soft tissues with sub-MPa fracture stress. Full article
(This article belongs to the Special Issue Polymer Materials for Biomedical Applications)
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12 pages, 1304 KiB  
Article
Development of Test Programs for the Biorelevant Characterization of Esophageal-Applied Dosage Forms
by Friederike Brokmann, Franziska Feindt, Werner Weitschies and Christoph Rosenbaum
Polymers 2023, 15(16), 3430; https://doi.org/10.3390/polym15163430 - 17 Aug 2023
Viewed by 727
Abstract
In the local treatment of the esophageal mucosa, the retention time of the different dosage forms, such as tablets, films or liquids, is of high relevance for the effective treatment of diseases. Unfortunately, there are only few in vitro models describing the esophageal [...] Read more.
In the local treatment of the esophageal mucosa, the retention time of the different dosage forms, such as tablets, films or liquids, is of high relevance for the effective treatment of diseases. Unfortunately, there are only few in vitro models describing the esophageal route of administration. To predict the behaviour of an esophageal-applied dosage form, it is necessary to simulate the site of application in a biorelevant way. The aim of this work was to develop two test setups for an esophageal peristalsis model which was described in a previous study. Different parameters such as flow rate, peristalsis, angle of inclination or mucous membrane were varied or introduced into the model. A stimulated and unstimulated modus were developed and tested with two different dosage forms. The time until the dosage form was cleared from the in vitro model was shorter with the stimulated than with the unstimulated modus. Also, esophageal-applied films had a prolonged transit time compared to a viscous syrup. The modification of the simulated esophageal surface made it possible to estimate the retention time of the dosage forms. It could be demonstrated that the residence time of a dosage form depends on different parameters affecting each other. Full article
(This article belongs to the Special Issue Polymer Materials for Biomedical Applications)
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16 pages, 9382 KiB  
Article
Production of Graft Copolymers of Cod Collagen with Butyl Acrylate and Vinyl Butyl Ether in the Presence of Triethylborane—Prospects for Use in Regenerative Medicine
by Lyudmila Semenycheva, Victoria O. Chasova, Nikita L. Pegeev, Marina A. Uromicheva, Alexander V. Mitin, Yulia L. Kuznetsova, Ekaterina A. Farafontova, Yulia P. Rubtsova, Daria D. Linkova and Marfa N. Egorikhina
Polymers 2023, 15(15), 3159; https://doi.org/10.3390/polym15153159 - 25 Jul 2023
Viewed by 890
Abstract
Collagen is a suitable material for regenerative medicine because it is characterized by its good biocompatibility. However, due to its fibrillar structure, it cannot organize itself into three-dimensional porous structures without additional modification. The introduction of synthetic monomer elements into the collagen macromolecules [...] Read more.
Collagen is a suitable material for regenerative medicine because it is characterized by its good biocompatibility. However, due to its fibrillar structure, it cannot organize itself into three-dimensional porous structures without additional modification. The introduction of synthetic monomer elements into the collagen macromolecules is a technique used to form three-dimensional, collagen-based, branched, and crosslinked structures. New types of graft copolymers made from cod collagen with a butyl acrylate and vinyl butyl ether copolymer in aqueous dispersion were obtained in the presence of triethylborane by a radical mechanism. The process of graft copolymer formation proceeded as usual by radical initiation, through radicals formed during triethylborane oxidation by oxygen residues, collagen borination, and reversible inhibition with the participation of a boroxyl radical. The characteristics of the graft copolymers were determined using methods of physical and chemical analysis (GPC, SEM, IR spectroscopy, etc.), while the cytotoxicity was assessed using the MTT assay method. It is shown that the grafting of alternating blocks of butyl acrylate and vinyl butyl ether to the protein macromolecules results in changes in the morphological pattern of the graft co-polymer in comparison with native collagen. This is manifested in the development of consolidations around the collagen fibers of the structural matrices, with the co-polymer cellular structure consisting of interpenetrating pores of unequal size. Additionally, it is important that the graft co-polymer solutions are not toxic at a certain concentration. The above properties confirm the promising nature of the technique’s application as the basis for producing new materials for regenerative medicine. Full article
(This article belongs to the Special Issue Polymer Materials for Biomedical Applications)
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13 pages, 2824 KiB  
Article
Preparation and Characterization of a Novel Tragacanth Gum/Chitosan/Sr-Nano-Hydroxyapatite Composite Membrane
by Shuo Tang, Liuyun Jiang, Zhihong Jiang, Yingjun Ma, Yan Zhang and Shengpei Su
Polymers 2023, 15(13), 2942; https://doi.org/10.3390/polym15132942 - 4 Jul 2023
Viewed by 1028
Abstract
It is a great challenge to obtain an ideal guided bone regeneration (GBR) membrane. In this study, tragacanth gum (GT) was introduced into a chitosan/nano-hydroxyapatite (CS/n-HA) system. The effects of different component ratios and strontium-doped nano-hydroxyapatite (Sr-HA) on the physical-chemical properties and degradation [...] Read more.
It is a great challenge to obtain an ideal guided bone regeneration (GBR) membrane. In this study, tragacanth gum (GT) was introduced into a chitosan/nano-hydroxyapatite (CS/n-HA) system. The effects of different component ratios and strontium-doped nano-hydroxyapatite (Sr-HA) on the physical-chemical properties and degradation behavior of the CS/Sr-n-HA/GT ternary composite membrane were investigated using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), contact angle, electromechanical universal tester and in vitro soaking in simulated body fluid (SBF). The results showed that CS could be ionically crosslinked with GT through electrostatic interaction, and Sr-n-HA was loaded via hydrogen bond, which endowed the GT/CS/n-HA composite membrane with good tensile strength and hydrophilicity. In addition, the results of immersion in SBF in vitro showed that CS/n-HA/GT composite membranes had different degradation rates and good apatite deposition by investigating the changes in pH value, weight loss, water absorption ratio, SEM morphology observation and tensile strength reduction. All results revealed that the CS/Sr-n-HA/GT (6:2:2) ternary composite membrane possessed the strongest ionic crosslinking of GT and CS, which was expected to obtain more satisfactory GBR membranes, and this study will provide new applications of GT in the field of biomedical membranes. Full article
(This article belongs to the Special Issue Polymer Materials for Biomedical Applications)
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