Immunomodulatory Biopolymers: From Drug Development to Successful Clinical Translation
A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".
Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 18700
Special Issue Editors
2. Department of Biology, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates
Interests: hydrogels; biomaterials; 3D bioprinting; nanoparticles; bioengineering
Special Issue Information
Dear Colleagues,
One of the most striking issues with conventional drug-delivery polymers is the elicitation of an immune response upon application in vivo. Different natural and artificial polymers have been used for various biomedical applications ranging from the delivery of drugs, metabolites, and genes to wound healing and regenerative medicine. However, most of these polymers suffer due to a compromise on immunogenicity and their respective biomedical applications. Although polymers from biomaterials of different origins have shown promise due to their animal origin, their immunogenicity, however small, is still a matter of concern for their clinical translation. Some polymers, both natural and synthetic, are hydrophilic, act as biological nests, and mimic the nature of tissue by being permeable to oxygen, ions, nutrients, metabolites, and waste products. Novel polymers demonstrate good biocompatibility, controllable stiffness for cell culture, and design flexibility, putting them in the spotlight for immunomodulation over the past few decades. They offer the ability to easily control immune responses by surface modulation via chemisorption/release of different adjuvants, mechanical properties, tissue adhesion, and the addition of immune-suppressing biomolecules.
This Special Issue will be dedicated to the presentation of novel biopolymers and micro/nanoparticles to address lacunae in the field that will truly transform drug delivery and long-term regenerative applications of biomaterials, biopolymers, and polymer conjugates.
Dr. Shabir Hassan
Dr. Amir K. Miri
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- polymers
- immunomodulation
- biopolymers
- physical conjugation
- immune response
- immunogenicity
