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Polymers
Special Issues
Advances in Polymer Drug Delivery Systems
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Advances in Polymer Drug Delivery Systems

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 1210

Special Issue Editor

Dr. Dayane Batista Tada

E-Mail Website
Guest Editor
Department of Science and Technology, Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, SP, Brazil
Interests: nanoparticles; nanomedicine; drug delivery systems; polymers

Special Issue Information

Dear Colleagues, 

Polymer drug delivery systems are an important research branch of polymer materials. Recent advances in nanomedicine have confirmed the importance of nanosystems as effective tools for the delivery of small molecules. These polymer loading systems can provide small molecules with good biocompatibility and targeting. Further, polymer drug delivery systems may allow the modulation of drug release kinetics, which could be due to the crosslinking process, biodegradable aspect, or even morphological changes in the conditions of the external medium, such as temperature, pH, and/or ionic strength. Common polymer materials used in drug delivery systems are polysaccharides, protein, chitin, chitosan, starch-based polymers, common biodegradable polymer materials, etc. 

This Special Issue focuses on the latest research on these topics, covering all aspects of structural modification, preparation, and application of polymeric materials for drug-loading systems. Your contribution is key for us to build a good communication platform for polymer drug delivery systems. We look forward to receiving your contributions.

Dr. Dayane Batista Tada
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug release
  • drug release kinetics
  • polysaccharides and protein
  • starch-based polymers
  • biocompatibility
  • biodegradable polymer materials
  • drug delivery systems

Published Papers (1 paper)

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Research

14 pages, 3550 KiB  
Article
Synthesis of a Rivastigmine and Insulin Combinational Mucoadhesive Nanoparticle for Intranasal Delivery
by Tahereh Jamshidnejad-Tosaramandani, Soheila Kashanian, Isaac Karimi and Helgi B. Schiöth
Polymers 2024, 16(4), 510; https://doi.org/10.3390/polym16040510 - 13 Feb 2024
Viewed by 876
Abstract
Efficient drug delivery remains a critical challenge for treating neurodegenerative diseases, such as Alzheimer’s disease (AD). Using innovative nanomaterials, delivering current medications like acetylcholinesterase inhibitors to the brain through the intranasal route is a promising strategy for managing AD. Here, we developed a [...] Read more.
Efficient drug delivery remains a critical challenge for treating neurodegenerative diseases, such as Alzheimer’s disease (AD). Using innovative nanomaterials, delivering current medications like acetylcholinesterase inhibitors to the brain through the intranasal route is a promising strategy for managing AD. Here, we developed a unique combinational drug delivery system based on N,N,N-trimethyl chitosan nanoparticles (NPs). These NPs encapsulate rivastigmine, the most potent acetylcholinesterase inhibitor, along with insulin, a complementary therapeutic agent. The spherical NPs exhibited a zeta potential of 17.6 mV, a size of 187.00 nm, and a polydispersity index (PDI) of 0.29. Our findings demonstrate significantly improved drug transport efficiency through sheep nasal mucosa using the NPs compared to drug solutions. The NPs exhibited transport efficiencies of 73.3% for rivastigmine and 96.9% for insulin, surpassing the efficiencies of the drug solutions, which showed transport efficiencies of 52% for rivastigmine and 21% for insulin ex vivo. These results highlight the potential of a new drug delivery system as a promising approach for enhancing nasal transport efficiency. These combinational mucoadhesive NPs offer a novel strategy for the simultaneous cerebral delivery of rivastigmine and insulin, which could prove helpful in developing effective treatments of AD and other neurodegenerative conditions. Full article
(This article belongs to the Special Issue Advances in Polymer Drug Delivery Systems)
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