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Polymers
Special Issues
Polymer Materials for Bioprinting and Tissue Engineering
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Polymer Materials for Bioprinting and Tissue Engineering

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (25 April 2023) | Viewed by 6259

Special Issue Editors

Prof. Dr. Fedor Senatov

E-Mail Website
Guest Editor
Director of Center for Biomedical Engineering, National University of Science and Technology "MISIS", Moscow, Russia
Interests: biomaterials; biopolymers; bioprinting; biomimetics; implants; hybrid materials; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Rajan Choudhary

E-Mail Website
Guest Editor
Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering, Riga Technical University, Kipsala Street 6A, LV-1048 Riga, Latvia
Interests: bioactive ceramics; ceramic/polymer composites; hydrogels; methods for preparing polymeric composites; polymer composites; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is concerned with the structure, properties, and applications of polymer materials, including bioresorbable and bioinert polymers and bioactive materials for use in tissue engineering applications. Topics may include structural features, microstructures, the relationship between structures and properties and biomedical characteristics, tailored–architected scaffolds, biomimetic structures, mechanical properties, bioprinting, and bioactivity. Articles in this Special Issue may also address bioactive materials such as hydrogels, biocomposites, smart polymers, shape memory polymers, bioimplants, tissue/cell engineering devices, tissue reconstruction, polymers for bioprinting, and cell–biomaterial interactions. Contributions should focus on fundamental results, mechanisms, and applications that will help to compile the current state of the art and to highlight their range of applications. Both original contributions and reviews are welcome.

Prof. Dr. Fedor Senatov
Dr. Rajan Choudhary
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • biopolymers
  • polymers for biomedical application
  • bioresorbable polymers
  • biomimetics
  • bioprinting
  • scaffolds
  • tissue engineering
  • tissue regeneration
  • cell engineering
  • polymer biocomposites
  • methods for preparing polymeric composites
  • surface modification and their characterization
  • hydrogelsinjectables

Published Papers (3 papers)

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Research

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13 pages, 4025 KiB  
Article
Mechanical, Structural, and Biological Characteristics of Polylactide/Wollastonite 3D Printed Scaffolds
by Rajan Choudhary, Inna Bulygina, Vladislav Lvov, Anna Zimina, Sergey Zhirnov, Evgeny Kolesnikov, Denis Leybo, Natalya Anisimova, Mikhail Kiselevskiy, Maria Kirsanova and Fedor Senatov
Polymers 2022, 14(19), 3932; https://doi.org/10.3390/polym14193932 - 20 Sep 2022
Cited by 6 | Viewed by 2161
Abstract
The present work aimed to study the synergistic response of bioresorbable polylactide/bioactive wollastonite scaffolds towards mechanical stability, mesenchymal stromal cell colonization, and antibacterial activity in the physiological environment. Wollastonite was synthesized at 800 °C within 2 h by sol-gel combustion method. The surface [...] Read more.
The present work aimed to study the synergistic response of bioresorbable polylactide/bioactive wollastonite scaffolds towards mechanical stability, mesenchymal stromal cell colonization, and antibacterial activity in the physiological environment. Wollastonite was synthesized at 800 °C within 2 h by sol-gel combustion method. The surface area was found to be 1.51 m2/g, and Transmission Electron Microscopy (TEM) micrographs indicated the presence of porous structures. Fused deposition modeling was used to prepare 3D-printed polylactide/wollastonite and polylactide/hydroxyapatite scaffolds. Scanning Electron Microscopy (SEM) micrographs confirmed the interconnected porous structure and complex geometry of the scaffolds. The addition of wollastonite decreased the contact angle of the scaffolds. The mechanical testing of scaffolds examined by computational simulation, as well as machine testing, revealed their non-load-bearing capacity. The chemical constituent of the scaffolds was found to influence the attachment response of different cells on their surface. The incorporation of wollastonite effectively reduced live bacterial attachment, whereas the colonization of mesenchymal cells was improved. This observation confirms polylactide/wollastonite scaffold possesses both bactericidal as well as cytocompatible properties. Thus, the risk of peri-implant bacterial film formation can be prevented, and the biological fixation of the scaffold at the defect site can be enhanced by utilizing these composites. Full article
(This article belongs to the Special Issue Polymer Materials for Bioprinting and Tissue Engineering)
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19 pages, 7138 KiB  
Article
Fabrication of Conductive Tissue Engineering Nanocomposite Films Based on Chitosan and Surfactant-Stabilized Graphene Dispersions
by Aleksandr S. Buinov, Elvira R. Gafarova, Ekaterina A. Grebenik, Kseniia N. Bardakova, Bato Ch. Kholkhoev, Nadezhda N. Veryasova, Pavel V. Nikitin, Nastasia V. Kosheleva, Boris S. Shavkuta, Anastasia S. Kuryanova, Vitalii F. Burdukovskii and Peter S. Timashev
Polymers 2022, 14(18), 3792; https://doi.org/10.3390/polym14183792 - 10 Sep 2022
Cited by 3 | Viewed by 2168
Abstract
Chitosan (CS)/graphene nanocomposite films with tunable biomechanics, electroconductivity and biocompatibility using polyvinylpyrrolidone (PVP) and Pluronic F108 (Plu) as emulsion stabilizers for the purpose of conductive tissue engineering were successfully obtained. In order to obtain a composite solution, aqueous dispersions of multilayered graphene stabilized [...] Read more.
Chitosan (CS)/graphene nanocomposite films with tunable biomechanics, electroconductivity and biocompatibility using polyvinylpyrrolidone (PVP) and Pluronic F108 (Plu) as emulsion stabilizers for the purpose of conductive tissue engineering were successfully obtained. In order to obtain a composite solution, aqueous dispersions of multilayered graphene stabilized with Plu/PVP were supplied with CS at a ratio of CS to stabilizers of 2:1, respectively. Electroconductive films were obtained by the solution casting method. The electrical conductivity, mechanical properties and in vitro and in vivo biocompatibility of the resulting films were assessed in relation to the graphene concentration and stabilizer type and they were close to that of smooth muscle tissue. According to the results of the in vitro cytotoxicity analysis, the films did not release soluble cytotoxic components into the cell culture medium. The high adhesion of murine fibroblasts to the films indicated the absence of contact cytotoxicity. In subcutaneous implantation in Wistar rats, we found that stabilizers reduced the brittleness of the chitosan films and the inflammatory response. Full article
(This article belongs to the Special Issue Polymer Materials for Bioprinting and Tissue Engineering)
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Review

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18 pages, 3426 KiB  
Review
Design, Fabrication, and Application of Mini-Scaffolds for Cell Components in Tissue Engineering
by Vladimir A. Mironov, Fedor S. Senatov, Elizaveta V. Koudan, Frederico D. A. S. Pereira, Vladimir A. Kasyanov, Jose Mauro Granjeiro and Leandra Santos Baptista
Polymers 2022, 14(23), 5068; https://doi.org/10.3390/polym14235068 - 22 Nov 2022
Cited by 2 | Viewed by 1548
Abstract
The concept of “lockyballs” or interlockable mini-scaffolds fabricated by two-photon polymerization from biodegradable polymers for the encagement of tissue spheroids and their delivery into the desired location in the human body has been recently introduced. In order to improve control of delivery, positioning, [...] Read more.
The concept of “lockyballs” or interlockable mini-scaffolds fabricated by two-photon polymerization from biodegradable polymers for the encagement of tissue spheroids and their delivery into the desired location in the human body has been recently introduced. In order to improve control of delivery, positioning, and assembly of mini-scaffolds with tissue spheroids inside, they must be functionalized. This review describes the design, fabrication, and functionalization of mini-scaffolds as well as perspectives on their application in tissue engineering for precisely controlled cell and mini-tissue delivery and patterning. The development of functionalized mini-scaffolds advances the original concept of “lockyballs” and opens exciting new prospectives for mini-scaffolds’ applications in tissue engineering and regenerative medicine and their eventual clinical translation. Full article
(This article belongs to the Special Issue Polymer Materials for Bioprinting and Tissue Engineering)
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