Biocompatible Polymers and Composite Materials for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1079

Special Issue Editors


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Guest Editor
Weinberg Research Center, School of Nuclear Science & Engineering, National Research Tomsk Polytechnic University, Tomsk 634050, Russia
Interests: material science; coatings; surface modification; plasma physics; composite materials

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Guest Editor
Department of Translational Cellular and Molecular Biomedicine, Chemical Faculty, National Research Tomsk State University, Tomsk 634050, Russia
Interests: biomaterial science; biocompatible polymers; implants; drug delivery; surface modification.

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Guest Editor
Weinberg Research Center, School of Nuclear Science & Engineering, National Research Tomsk Polytechnic University, Tomsk 634050, Russia
Interests: biocompatible polymers; micro/mano-motors; additively manufactured implants; drug delivery; tissue engineering; surface modification; coatings

Special Issue Information

Dear Colleagues,

The application of polymers and polymer-based composite materials is essential and indispensable in modern biomedicine. This Special Issue aims to present an overview of novelties and improvements in the field of biocompatible polymers and composite polymer-based materials for an extensive range of biomedical applications. Polymeric materials can be employed in a living body, as well as in medical devices. This is of significant interest not only in research, but also for the application side of the medical industry, and for medical professionals. Therefore, this Special Issue is, for example, of interest with regard to the surface modification of additive manufactured novel or enhanced biocompatible polymer structures (such as 3D implants or non-woven scaffolds), and for polymer structures utilized in medical devices (e.g., filters and membranes). Improvements can manifest as higher efficiency filters or superior cell cultivation with enhanced antibacterial properties and simultaneous non-cytotoxicity in the case of implants. Moreover, we are searching for articles addressing creative polymer-based drug delivery systems with innovative drug encapsulation or incorporation systems with the potential for long-term drug release or smart drug release approaches. This Special Issue also aims to present the current state of the art in the new research field of “smart” implants.

Prof. Dr. Sergei I. Tverdokhlebov
Prof. Dr. Irina Kurzina
Dr. Sven Rutkowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical applications
  • biocompatibility
  • additive manufacturing
  • drug delivery
  • coatings
  • polymer structures
  • biopolymers
  • hydrogels
  • surface modification
  • polymer composites

Published Papers (1 paper)

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Research

17 pages, 16431 KiB  
Article
Nitrogen Plasma Treatment of Composite Materials Based on Polylactic Acid and Hydroxyapatite
by Ulyana V. Khomutova, Alena G. Korzhova, Anastasia A. Bryuzgina, Olesya A. Laput, Irina V. Vasenina, Yuriy H. Akhmadeev, Vladimir V. Shugurov, Ivan I. Azhazha, Yelena G. Shapovalova, Aleksandr V. Chernyavskii and Irina A. Kurzina
Polymers 2024, 16(5), 627; https://doi.org/10.3390/polym16050627 - 25 Feb 2024
Viewed by 786
Abstract
The effect of surface modification by an arc discharge plasma in a nitrogen flow with treatment durations of 5 and 10 min on the physicochemical properties and biocompatibility of the surface of composites based on polylactic acid and hydroxyapatite (PLA/HA) with different mass [...] Read more.
The effect of surface modification by an arc discharge plasma in a nitrogen flow with treatment durations of 5 and 10 min on the physicochemical properties and biocompatibility of the surface of composites based on polylactic acid and hydroxyapatite (PLA/HA) with different mass ratios (80/20, 70/30, 60/40) has been investigated. The aim of this work was to show the correlation between the changes of the physicochemical characteristics (chemical compound, morphology, wettability) of the surface layer of the PLA/HA composites and the cell viability (macrophages) in the presence of the plasma-modified materials. The dependence of alterations of the functional properties (wettability, biocompatibility) on the change in the chemical composition under the plasma exposure has been established. The chemical composition was studied using X-ray photoelectron spectroscopy (XPS), the surface morphology was researched with scanning electron microscopy (SEM), and the wettability of the composite’s surface was analyzed by measuring the contact angle and surface energy calculation. In addition, the viability of macrophages was investigated when the macrophages from three donors interacted with a modified PLA/HA surface. It was found that the formation of the new functional groups, –C-N and N-C=O/C=O, improves the wettability of the surface of the composites and promotes the viability of macrophages in the presence of the composite materials. The fundamental principles for obtaining promising materials with the required properties for eliminating bone defects have been created. Full article
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