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Polymers
Special Issues
Polymer Composites in Biomedical Applications III
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Polymer Composites in Biomedical Applications III

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1726

Special Issue Editors

Dr. Donatella Duraccio

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Guest Editor
National Research Council (CNR), STEMS - Strada delle Cacce 73, 10135 Turin, Italy
Interests: polymer composites and nanocomposites; biopolymers; coatings; structure–property relationship; food packaging; biomedical engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Giulia Faga

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Guest Editor
National Research Council (CNR), STEMS - Strada delle Cacce 73, 10135 Turin, Italy
Interests: composite materials; oxidic bioceramics; coatings; wear; industrial engineering; surface properties
Special Issues, Collections and Topics in MDPI journals
Dr. Giovanna Gomez D’Ayala

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Guest Editor
National Research Council (CNR), IPCB, Via Campi Flegrei 34, 80078 Pozzuoli, NA, Italy
Interests: polymer synthesis; stimuli-responsive polymers; biocomposites; biomaterials; wound healing; bone regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that the global demand for polymer composite biomaterials in various medical applications has increased significantly in recent years. Recent developments in materials science and biomedical engineering have enabled impressive progress in attempts to develop innovative polymer composite biomaterials, owing to their tailorable manufacturing processes and characteristics comparable to those of the host tissues. However, for successful applications, some properties, such as mechanical properties, durability, biodegradability, bioactivity, etc., must be optimized and tuned as a function of the specific application.

This Special Issue focuses on the preparation and characterization of polymer composites for various biomedical applications. There are no restrictions in terms of biomedical applications (i.e., soft tissue, hard tissue, and others), nature (biodegradable or not), composition, polymer type (natural or synthetic polymers), or nature and dimension of the fillers. Original contributions as well as reviews are both welcome.

Dr. Donatella Duraccio
Dr. Maria Giulia Faga
Dr. Giovanna Gomez D’Ayala
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer composite
  • biomedical application
  • tissue engineering
  • mechanical properties
  • soft tissue
  • hard tissue
  • bioactivity
  • durability
  • biodegradability

Published Papers (2 papers)

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15 pages, 9731 KiB  
Article
Citric Acid Cross-Linked Gelatin-Based Composites with Improved Microhardness
by Abdulrraouf Taboun, Marija Jovanovic, Milos Petrovic, Ivana Stajcic, Ivan Pesic, Dusica B. Stojanovic and Vesna Radojevic
Polymers 2024, 16(8), 1077; https://doi.org/10.3390/polym16081077 - 12 Apr 2024
Viewed by 318
Abstract
The aim of this study is to investigate the influence of cross-linking and reinforcements in gelatin on the physico-mechanical properties of obtained composites. The gelatin-based composites cross-linked with citric acid (CA) were prepared: gelatin type B (GB) and β-tricalcium phosphate (β-TCP) and novel [...] Read more.
The aim of this study is to investigate the influence of cross-linking and reinforcements in gelatin on the physico-mechanical properties of obtained composites. The gelatin-based composites cross-linked with citric acid (CA) were prepared: gelatin type B (GB) and β-tricalcium phosphate (β-TCP) and novel hybrid composite GB with β-TCP and hydroxyapatite (HAp) particles, and their structure, thermal, and mechanical properties were compared with pure gelatin B samples. FTIR analysis revealed that no chemical interaction between the reinforcements and gelatin matrix was established during the processing of hybrid composites by the solution casting method, proving the particles had no influence on GB cross-linking. The morphological investigation of hybrid composites revealed that cross-linking with CA improved the dispersion of particles, which further led to an increase in mechanical performance. The microindentation test showed that the hardness value was increased by up to 449%, which shows the high potential of β-TCP and HAp particle reinforcement combined with CA as a cross-linking agent. Furthermore, the reduced modulus of elasticity was increased by up to 288%. Results of the MTT assay on L929 cells have revealed that the hybrid composite GB-TCP-HA-CA was not cytotoxic. These results showed that GB cross-linked with CA and reinforced with different calcium phosphates presents a valuable novel material with potential applications in dentistry. Full article
(This article belongs to the Special Issue Polymer Composites in Biomedical Applications III)
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27 pages, 5480 KiB  
Article
Nanosilver-Functionalized Hybrid Hydrogels of Carboxymethyl Cellulose/Poly(Vinyl Alcohol) with Antibacterial Activity for Prevention and Therapy of Infections of Diabetic Chronic Wounds
by Nádia S. V. Capanema, Alexandra A. P. Mansur, Sandhra M. Carvalho, Talita Martins, Maysa S. Gonçalves, Rafaella S. Andrade, Elaine M. S. Dorneles, Letícia C. D. Lima, Érika L. F. C. de Alvarenga, Emanuel V. B. da Fonseca, Marcos Augusto de Sá, Andrey P. Lage, Zelia I. P. Lobato and Herman S. Mansur
Polymers 2023, 15(23), 4542; https://doi.org/10.3390/polym15234542 - 27 Nov 2023
Cited by 1 | Viewed by 1042
Abstract
Diabetic foot ulcers (DFUs) are considered one of the most severe chronic complications of diabetes and can lead to amputation in severe cases. In addition, bacterial infections in diabetic chronic wounds aggravate this scenario by threatening human health. Wound dressings made of polymer [...] Read more.
Diabetic foot ulcers (DFUs) are considered one of the most severe chronic complications of diabetes and can lead to amputation in severe cases. In addition, bacterial infections in diabetic chronic wounds aggravate this scenario by threatening human health. Wound dressings made of polymer matrices with embedded metal nanoparticles can inhibit microorganism growth and promote wound healing, although the current clinical treatments for diabetic chronic wounds remain unsatisfactory. In this view, this research reports the synthesis and characterization of innovative hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) chemically crosslinked by citric acid (CA) functionalized with silver nanoparticles (AgNPs) generated in situ using an eco-friendly aqueous process. The results assessed through comprehensive in vitro and in vivo assays demonstrated that these hybrid polymer hydrogels functionalized with AgNPs possess physicochemical properties, cytocompatibility, hemocompatibility, bioadhesion, antibacterial activity, and biocompatibility suitable for wound dressings to support chronic wound healing process as well as preventing and treating bacterial infections. Hence, it can be envisioned that, with further research and development, these polymer-based hybrid nanoplatforms hold great potential as an important tool for creating a new generation of smart dressings for treating chronic diabetic wounds and opportunistic bacterial infections. Full article
(This article belongs to the Special Issue Polymer Composites in Biomedical Applications III)
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