Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
4.5
Journals
Plants
Special Issues
Neuroprotective Compounds Isolated from Plant Extracts
share announcement

Neuroprotective Compounds Isolated from Plant Extracts

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 7595

Special Issue Editors

Dr. Namki Cho

E-Mail Website
Guest Editor
College of Pharmacy, Chonnam National University 77 Youngbong-ro, Buk-gu, Gwangju 61186, Republic of Korea
Interests: natural product chemistry; phytochemistry: bioactive natural products; antiproliferative; neuroprotective
Dr. Hee Min Yoo

E-Mail Website
Guest Editor
Biometrology Group, Korea Research Institute of Standards and Science (KRISS), Daejeon 34113, Korea
Interests: neuroprotective Effect of Plant Extracts
Prof. Changju Chun

E-Mail Website
Guest Editor
College of Pharmacy, Chonnam National University, Gwangju 61186, Korea
Interests: phytochemistry; bioconjugates; delivery carriers for biopharmaceutcals; antiproliferative; neuroprotective

Special Issue Information

Dear Colleagues,

Oxidative stress and excessive inflammatory responses in the CNS are associated with various neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Although numerous natural product compounds have been proposed as neuroprotective agents, only a few have been proven to be effective against neurodegenerative diseases. Therefore, it is important to find out neuroprotective compounds isolated from natural products that have antioxidant or anti-inflammatory effects in the brain. The main natural product drug candidates generated by plant extracts are secondary metabolites categorized as terpenes, phenols, nitrogen or sulphur-containing compounds, and so on.

This Special Issue of Plants will highlight the isolation of compounds from medicinal plant extracts, and their neuroprotective biological activity in vitro or in vivo.

Dr. Namki Cho
Dr. Hee Min Yoo
Prof. Changju Chun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • antioxidant
  • anti-inflammatory
  • natural product

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 4294 KiB  
Article
High-Purity Preparation of Enzyme Transformed Trans-Crocetin Reclaimed from Gardenia Fruit Waste
by Charng-Cherng Chyau, Chu-Ying Chiu, Hung-Lin Hsieh, David Wang-Chi Hsieh, Chong-Ru Hsieh, Chi-Huang Chang and Robert Y. Peng
Plants 2022, 11(3), 281; https://doi.org/10.3390/plants11030281 - 21 Jan 2022
Cited by 5 | Viewed by 2774
Abstract
The recovery of physiologically bioactive ingredients from agricultural wastes as an abundant and low-cost source for the production of high value-added mutraceuticlas has been recognized and supported for the commercial interests and sustainable managements. In the extraction of geniposide for the development of [...] Read more.
The recovery of physiologically bioactive ingredients from agricultural wastes as an abundant and low-cost source for the production of high value-added mutraceuticlas has been recognized and supported for the commercial interests and sustainable managements. In the extraction of geniposide for the development of natural food colorants from the dried fruits of Gardenia jasminoides Rubiaceae, the gardenia fruit waste (GFW) still remaining 0.86% (w/w) of crocins has always been discarded without any further treatments Until now, there was no simple and effective protocol for high-purity trans-crocein (TC) preparation without the coexistence of non-biologically active cis-crocein from GFW. We proposed an effective process to obtain the compound as follows. Crocins were extracted firstly by 50% of ethanol in the highest yield of 8.61 mg/g (w/w) from GFW. After the HPD-100 column fractionation in the collecting of crocins, the conversion ratio of 75% of crocins to crocetins can be obtained from the commercial available enzyme- Celluclast® 1.5 L. The crocins hydrolyzed products, were then separated through the HPD-100 resin adsorption and finally purified with the centrifugal partition chromatography (CPC) in single-step to obtain TC in a purity of 96.76 ± 0.17%. Conclusively, the effective enzyme transformation and purification co-operated with CPC technologies on crocins resulted in a high purity product of TC may be highly application in the commercial production. Full article
(This article belongs to the Special Issue Neuroprotective Compounds Isolated from Plant Extracts)
►▼ Show Figures

Figure 1

Review

Jump to: Research

22 pages, 3169 KiB  
Review
Roles of Syzygium in Anti-Cholinesterase, Anti-Diabetic, Anti-Inflammatory, and Antioxidant: From Alzheimer’s Perspective
by Mira Syahfriena Amir Rawa, Mohd Khairul Nizam Mazlan, Rosliza Ahmad, Toshihiko Nogawa and Habibah A. Wahab
Plants 2022, 11(11), 1476; https://doi.org/10.3390/plants11111476 - 31 May 2022
Cited by 8 | Viewed by 4110
Abstract
Alzheimer’s disease (AD) causes progressive memory loss and cognitive dysfunction. It is triggered by multifaceted burdens such as cholinergic toxicity, insulin resistance, neuroinflammation, and oxidative stress. Syzygium plants are ethnomedicinally used in treating inflammation, diabetes, as well as memory impairment. They are rich [...] Read more.
Alzheimer’s disease (AD) causes progressive memory loss and cognitive dysfunction. It is triggered by multifaceted burdens such as cholinergic toxicity, insulin resistance, neuroinflammation, and oxidative stress. Syzygium plants are ethnomedicinally used in treating inflammation, diabetes, as well as memory impairment. They are rich in antioxidant phenolic compounds, which can be multi-target neuroprotective agents against AD. This review attempts to review the pharmacological importance of the Syzygium genus in neuroprotection, focusing on anti-cholinesterase, anti-diabetic, anti-inflammatory, and antioxidant properties. Articles published in bibliographic databases within recent years relevant to neuroprotection were reviewed. About 10 species were examined for their anti-cholinesterase capacity. Most studies were conducted in the form of extracts rather than compounds. Syzygium aromaticum (particularly its essential oil and eugenol component) represents the most studied species owing to its economic significance in food and therapy. The molecular mechanisms of Syzygium species in neuroprotection include the inhibition of AChE to correct cholinergic transmission, suppression of pro-inflammatory mediators, oxidative stress markers, RIS production, enhancement of antioxidant enzymes, the restoration of brain ions homeostasis, the inhibition of microglial invasion, the modulation of ß-cell insulin release, the enhancement of lipid accumulation, glucose uptake, and adiponectin secretion via the activation of the insulin signaling pathway. Additional efforts are warranted to explore less studied species, including the Australian and Western Syzygium species. The effectiveness of the Syzygium genus in neuroprotective responses is markedly established, but further compound isolation, in silico, and clinical studies are demanded. Full article
(This article belongs to the Special Issue Neuroprotective Compounds Isolated from Plant Extracts)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop