Uses and Properties of Citrus Flavonoids

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 2575

Special Issue Editor


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Guest Editor
Department of Molecular Biosciences and Bioengineering, University of Hawai’i at Manoa, Honolulu, HI, USA
Interests: antioxidant activity; phytochemicals; natural product chemistry; bioactivity; chromatography; plant physiology; plant biology; enzymology; crop protection; agriculture
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Special Issue Information

Dear Colleagues,

Citrus is an abiding horticultural crop that has been cultivated for centuries. An array of citrus species, as well as cultivars within each species, exists in modern times with each having their own particular genetic, molecular biological, and biochemical properties. Citrus remains an important agricultural commodity and is the highest value crop in international trade of fruit and processed products such as juices, flavourings, essential oils, cosmetics, and the like. The genus has long been studied for its unique complement of biochemicals, often with a particular focus on natural products. These compounds have been demonstrated not only to directly impact agricultural value and marketability, but also further provide a variety of nutritional, health, and other benefits for humanity. Biosynthesis and accumulation of these compounds in citrus has, and continues to be, a major driving force for study. The long history of citrus research has led to a breadth of available information producing a strong scientific framework on which to develop novel studies. This makes citrus an excellent system in which to investigate broader biological questions. This Special Issue encompasses a variety of topics related to the production, accumulation, biosynthesis and other associated issues for citrus natural products, as well as their agricultural, nutritional, and medicinal utilization.

Dr. Daniel K. Owens
Guest Editor

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Keywords

  • natural products
  • biosynthesis
  • enzymology
  • metabolic profiling
  • plant disease marketability
  • nutritional value
  • health effects

Published Papers (1 paper)

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15 pages, 4613 KiB  
Article
Promising Natural Compounds against Flavivirus Proteases: Citrus Flavonoids Hesperetin and Hesperidin
by Raphael J. Eberle, Danilo S. Olivier, Marcos S. Amaral, Dieter Willbold, Raghuvir K. Arni and Monika A. Coronado
Plants 2021, 10(10), 2183; https://doi.org/10.3390/plants10102183 - 14 Oct 2021
Cited by 8 | Viewed by 2045
Abstract
Ubiquitous in citrus plants, Hesperidin and Hesperetin flavanones possess several biological functions, including antiviral activity. Arbovirus infections pose an ever-increasing threat to global healthcare systems. Among the severe arboviral infections currently known are those caused by members of the Flavivirus genus, for example, [...] Read more.
Ubiquitous in citrus plants, Hesperidin and Hesperetin flavanones possess several biological functions, including antiviral activity. Arbovirus infections pose an ever-increasing threat to global healthcare systems. Among the severe arboviral infections currently known are those caused by members of the Flavivirus genus, for example, Dengue Virus—DENV, Yellow Fever Virus—YFV, and West Nile Virus—WNV. In this study, we characterize the inhibitory effect of Hesperidin and Hesperetin against DENV2, YFV, and WNV NS2B/NS3 proteases. We report the noncompetitive inhibition of the NS2B/NS3pro by the two bioflavonoids with half maximal inhibitory concentration (IC50) values <5 µM for HST and <70 µM for HSD. The determined dissociation constants (KD) of both flavonoids is significantly below the threshold value of 30 µM. Our findings demonstrate that a new generation of anti-flavivirus drugs could be developed based on selective optimization of both molecules. Full article
(This article belongs to the Special Issue Uses and Properties of Citrus Flavonoids)
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