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Photonics
Special Issues
Adaptive Optics for Biological Imaging
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Adaptive Optics for Biological Imaging

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "Biophotonics and Biomedical Optics".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 7043

Special Issue Editors

Dr. Fan Wang

E-Mail Website
Guest Editor
School of Electrical and Data Engineering, University of Technology Sydney, Sydney, Australia
Interests: bio-imaging; optical tweezers; nanophotonics; condensed matter physics
Special Issues, Collections and Topics in MDPI journals
Dr. Xusan Yang

E-Mail Website
Guest Editor
Mong Senior Cornell Neurotech Fellow, School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14850, USA
Interests: super-resolution microscopy and three photon microscopy development; adaptive optics; OCT
Special Issues, Collections and Topics in MDPI journals
Dr. Bo Li

E-Mail Website
Guest Editor
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14850, USA
Interests: three-photon laser scanning fluorescence microscopy; two-photon microscopy; Raman microscopy; neuroscience; brain research; fiber laser development; telecommunication

Special Issue Information

Dear Colleagues,

Adaptive optics (AO) have become a big success in the field of Astronomy, being used to correct the wavefront distortion induced by atmosphere propagating. In the biomedical imaging field, AO is becoming an ever more commonplace technology for microscopy, leading to aberration-free imaging. A series of advances on both devices and controlling methods have been made in the past decades to make AO more impactful in biomedical imaging.


This Special Issue will focus on a comprehensive study on AO technology spanning analyzing methods, optical systems, and microscopy applications. Original research articles and perspectives are welcome from multidisciplinary research fields, with focus on topics including, but not limited to:

  • Novel design of AO system for biomedical optical sensing and imaging;
  • Analyzing methods for imaging and sensing through thick diffusive layers;
  • Aberration correction mechanism for operating the AO related devices, e.g., SLM and DMD;
  • Biomedical applications of the AO system, e.g., ophthalmology, super-resolution microscopy, OCT, laser scanning microscope (confocal and multiphoton microscope), photoacoustic tomography/microscope, optogenetics, and optical tweezers.

Dr. Fan Wang
Dr. Xusan Yang
Dr. Bo Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adaptive optics
  • wavefront sensing
  • biomedical imaging

Published Papers (2 papers)

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Research

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10 pages, 22145 KiB  
Communication
Study on Aberration Correction of Adaptive Optics Based on Convolutional Neural Network
by Jin Li, Luwei Wang, Yong Guo, Yangrui Huang, Zhigang Yang, Wei Yan and Junle Qu
Photonics 2021, 8(9), 377; https://doi.org/10.3390/photonics8090377 - 08 Sep 2021
Cited by 2 | Viewed by 2445
Abstract
The existence of aberrations has always been an important limiting factor in the imaging field. Especially in optical microscopy imaging, the accumulated aberration of the optical system and the biological samples distorts the wavefront on the focal plane, thereby reducing the imaging resolution. [...] Read more.
The existence of aberrations has always been an important limiting factor in the imaging field. Especially in optical microscopy imaging, the accumulated aberration of the optical system and the biological samples distorts the wavefront on the focal plane, thereby reducing the imaging resolution. Here, we propose an adaptive optical aberration correction method based on convolutional neural network. By establishing the relationship between the Zernike polynomial and the distorted wavefront, with the help of the fast calculation advantage of an artificial intelligence neural network, the distorted wavefront information can be output in a short time for the reconstruction of the wavefront to achieve the purpose of improving imaging resolution. Experimental results show that this method can effectively compensate the aberrations introduced by the system, agarose and HeLa cells. After correcting, the point spread function restored the doughnut-shape, and the resolution of the HeLa cell image increased about 20%. Full article
(This article belongs to the Special Issue Adaptive Optics for Biological Imaging)
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Review

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22 pages, 3187 KiB  
Review
Application of Adaptive Optics in Ophthalmology
by Lixin Liu, Zhaoqing Wu, Meijie Qi, Yanru Li, Meiling Zhang, Dingying Liao and Peng Gao
Photonics 2022, 9(5), 288; https://doi.org/10.3390/photonics9050288 - 23 Apr 2022
Cited by 5 | Viewed by 3622
Abstract
The eye, the photoreceptive organ used to perceive the external environment, is of great importance to humans. It has been proven that some diseases in humans are accompanied by fundus changes; therefore, the health status of people may be interpreted from retinal images. [...] Read more.
The eye, the photoreceptive organ used to perceive the external environment, is of great importance to humans. It has been proven that some diseases in humans are accompanied by fundus changes; therefore, the health status of people may be interpreted from retinal images. However, the human eye is not a perfect refractive system for the existence of ocular aberrations. These aberrations not only affect the ability of human visual discrimination and recognition, but restrict the observation of the fine structures of human eye and reduce the possibility of exploring the mechanisms of eye disease. Adaptive optics (AO) is a technique that corrects optical wavefront aberrations. Once integrated into ophthalmoscopes, AO enables retinal imaging at the cellular level. This paper illustrates the principle of AO in correcting wavefront aberrations in human eyes, and then reviews the applications and advances of AO in ophthalmology, including the adaptive optics fundus camera (AO-FC), the adaptive optics scanning laser ophthalmoscope (AO-SLO), the adaptive optics optical coherence tomography (AO-OCT), and their combined multimodal imaging technologies. The future development trend of AO in ophthalmology is also prospected. Full article
(This article belongs to the Special Issue Adaptive Optics for Biological Imaging)
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