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6.9
5.4
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Pharmaceutics
Special Issues
Tissue Diagnosis, Phototherapy and Drug Delivery
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Tissue Diagnosis, Phototherapy and Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 10154

Special Issue Editors

Prof. Dr. Yury V. Kistenev

E-Mail Website
Guest Editor
Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, 36 Lenin Av., 634050 Tomsk, Russia
Interests: laser molecular spectroscopy; laser molecular imaging; machine learning; medical diagnosis
Special Issues, Collections and Topics in MDPI journals
Dr. Tianhong Dai

E-Mail Website
Guest Editor
Wellman Center for Photomedicine, Mass General Research Institute, Harvard Medical School, Boston, MA 02116, USA
Interests: biomedical optics; photodynamic therapy; UVC therapy; photothermal therapy; light-based therapy for multi-drug-resistant bacterial infections; photobiomodulation
Prof. Dr. Dmitry Gorin

E-Mail Website
Guest Editor
Center for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 3 Nobel str, 121205 Moscow, Russia
Interests: biophotonics; biophysics; physics of colloids and interfaces; theranostics; multimodal contrast agents; sensors for liquid and gas biopsy; target drug delivery

Special Issue Information

Dear Colleagues,

The combination of the delivery of special substances into tissues and consequent light action opens the way to numerous methods of tissue medical diagnosis and therapy, including photodynamic therapy (PDT), photothermal therapy (PPT), and photobiomodulation. The current development in this field is associated with the creation of complex substances allowing the combination of beneficial effects and the effective control of the therapeutic process by biophotonic tools. 

This Special Issue entitled “Tissue Diagnosis, Phototherapy and Drug Delivery” aims to present the current state-of-the-art in the creation of more effective substances and delivery techniques for PDT and PTT, as well as new optical methods of tissue diagnosis, PDT/PTT implementation, and control. New and renovated dyes, nanomaterials, and their composites are welcome.

We invite researchers from the pharmaceutical/food industry or academia to submit original research articles, review articles, or commentaries. This Special Issue will provide researchers with an up-to-date resource on how biophotonics can help in phototherapy and diagnosis.

Prof. Dr. Yury V. Kistenev
Dr. Tianhong Dai
Prof. Dr. Dmitry Gorin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical methods of tissue study
  • tissue optical clearing
  • phototherapy
  • PDT/PTT implementation and control
  • drug delivery in phototherapy and diagnosis
  • dyes
  • nanomaterials
  • composites in PDT and PTT

Published Papers (4 papers)

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Research

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22 pages, 14538 KiB  
Article
Quantitative Assessment of Low-Dose Photodynamic Therapy Effects on Diabetic Wound Healing Using Raman Spectroscopy
by Hala Zuhayri, Alice A. Samarinova, Alexey V. Borisov, David A. Lopez Guardado, Houssain Baalbaki, Natalya A. Krivova and Yury V. Kistenev
Pharmaceutics 2023, 15(2), 595; https://doi.org/10.3390/pharmaceutics15020595 - 10 Feb 2023
Viewed by 1608
Abstract
One of challenges that faces diabetes is the wound healing process. The delayed diabetic wound healing is caused by a complicated molecular mechanism involving numerous physiological variables. Low-dose photodynamic therapy (LDPDT) provides excellent results in rejuvenation and wound healing. In this study, the [...] Read more.
One of challenges that faces diabetes is the wound healing process. The delayed diabetic wound healing is caused by a complicated molecular mechanism involving numerous physiological variables. Low-dose photodynamic therapy (LDPDT) provides excellent results in rejuvenation and wound healing. In this study, the LDPDT effect on diabetic wounds in mice was studied using two photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser dose expositions of 1 J/cm2 and 4 J/cm2 by Raman spectroscopy (RS). The latter was used as a noninvasive method, providing specific information about tissue state based on the fundamental vibrational modes of its molecular components. RS allows high spatial resolution acquisition of biochemical and structural information through the generation of point spectra or spectral images. An approach to in vivo quantitative assessment of diabetic wound healing state was developed. This approach is based on an application of the principal component analysis combined with the Mahalanobis metrics to skin Raman spectra, in particular, intensities of the amide I and CH2 bands. Full article
(This article belongs to the Special Issue Tissue Diagnosis, Phototherapy and Drug Delivery)
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19 pages, 5823 KiB  
Article
Discovering Glioma Tissue through Its Biomarkers’ Detection in Blood by Raman Spectroscopy and Machine Learning
by Denis Vrazhnov, Anna Mankova, Evgeny Stupak, Yury Kistenev, Alexander Shkurinov and Olga Cherkasova
Pharmaceutics 2023, 15(1), 203; https://doi.org/10.3390/pharmaceutics15010203 - 06 Jan 2023
Cited by 7 | Viewed by 2628
Abstract
The most commonly occurring malignant brain tumors are gliomas, and among them is glioblastoma multiforme. The main idea of the paper is to estimate dependency between glioma tissue and blood serum biomarkers using Raman spectroscopy. We used the most common model of human [...] Read more.
The most commonly occurring malignant brain tumors are gliomas, and among them is glioblastoma multiforme. The main idea of the paper is to estimate dependency between glioma tissue and blood serum biomarkers using Raman spectroscopy. We used the most common model of human glioma when continuous cell lines, such as U87, derived from primary human tumor cells, are transplanted intracranially into the mouse brain. We studied the separability of the experimental and control groups by machine learning methods and discovered the most informative Raman spectral bands. During the glioblastoma development, an increase in the contribution of lactate, tryptophan, fatty acids, and lipids in dried blood serum Raman spectra were observed. This overlaps with analogous results of glioma tissues from direct Raman spectroscopy studies. A non-linear relationship between specific Raman spectral lines and tumor size was discovered. Therefore, the analysis of blood serum can track the change in the state of brain tissues during the glioma development. Full article
(This article belongs to the Special Issue Tissue Diagnosis, Phototherapy and Drug Delivery)
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19 pages, 4199 KiB  
Article
Penetration Depth of Propylene Glycol, Sodium Fluorescein and Nile Red into the Skin Using Non-Invasive Two-Photon Excited FLIM
by Mohammad Alhibah, Marius Kröger, Sabine Schanzer, Loris Busch, Jürgen Lademann, Ingeborg Beckers, Martina C. Meinke and Maxim E. Darvin
Pharmaceutics 2022, 14(9), 1790; https://doi.org/10.3390/pharmaceutics14091790 - 26 Aug 2022
Cited by 7 | Viewed by 2389
Abstract
The stratum corneum (SC) forms a strong barrier against topical drug delivery. Therefore, understanding the penetration depth and pathways into the SC is important for the efficiency of drug delivery and cosmetic safety. In this study, TPT-FLIM (two-photon tomography combined with [...] Read more.
The stratum corneum (SC) forms a strong barrier against topical drug delivery. Therefore, understanding the penetration depth and pathways into the SC is important for the efficiency of drug delivery and cosmetic safety. In this study, TPT-FLIM (two-photon tomography combined with fluorescence lifetime imaging) was applied as a non-invasive optical method for the visualization of skin structure and components to study penetration depths of exemplary substances, like hydrophilic propylene glycol (PG), sodium fluorescein (NaFl) and lipophilic Nile red (NR) into porcine ear skin ex vivo. Non-fluorescent PG was detected indirectly based on the pH-dependent increase in the fluorescence lifetime of SC components. The pH similarity between PG and viable epidermis limited the detection of PG. NaFl reached the viable epidermis, which was also proved by laser scanning microscopy. Tape stripping and confocal Raman micro-spectroscopy were performed additionally to study NaFl, which revealed penetration depths of ≈5 and ≈8 μm, respectively. Lastly, NR did not permeate the SC. We concluded that the amplitude-weighted mean fluorescence lifetime is the most appropriate FLIM parameter to build up penetration profiles. This work is anticipated to provide a non-invasive TPT-FLIM method for studying the penetration of topically applied drugs and cosmetics into the skin. Full article
(This article belongs to the Special Issue Tissue Diagnosis, Phototherapy and Drug Delivery)
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Review

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42 pages, 6320 KiB  
Review
Isolation, Detection and Analysis of Circulating Tumour Cells: A Nanotechnological Bioscope
by Upama Das, Soumyabrata Banik, Sharmila Sajankila Nadumane, Shweta Chakrabarti, Dharshini Gopal, Shama Prasada Kabekkodu, Pornsak Srisungsitthisunti, Nirmal Mazumder and Rajib Biswas
Pharmaceutics 2023, 15(1), 280; https://doi.org/10.3390/pharmaceutics15010280 - 13 Jan 2023
Cited by 2 | Viewed by 2910
Abstract
Cancer is one of the dreaded diseases to which a sizeable proportion of the population succumbs every year. Despite the tremendous growth of the health sector, spanning diagnostics to treatment, early diagnosis is still in its infancy. In this regard, circulating tumour cells [...] Read more.
Cancer is one of the dreaded diseases to which a sizeable proportion of the population succumbs every year. Despite the tremendous growth of the health sector, spanning diagnostics to treatment, early diagnosis is still in its infancy. In this regard, circulating tumour cells (CTCs) have of late grabbed the attention of researchers in the detection of metastasis and there has been a huge surge in the surrounding research activities. Acting as a biomarker, CTCs prove beneficial in a variety of aspects. Nanomaterial-based strategies have been devised to have a tremendous impact on the early and rapid examination of tumor cells. This review provides a panoramic overview of the different nanotechnological methodologies employed along with the pharmaceutical purview of cancer. Initiating from fundamentals, the recent nanotechnological developments toward the detection, isolation, and analysis of CTCs are comprehensively delineated. The review also includes state-of-the-art implementations of nanotechnological advances in the enumeration of CTCs, along with future challenges and recommendations thereof. Full article
(This article belongs to the Special Issue Tissue Diagnosis, Phototherapy and Drug Delivery)
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