Biomaterials for Neural Tissue Engineering

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2565

Special Issue Editor


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Guest Editor
Laboratory of Molecular Neurobiology, Department of Biochemistry, Universidade Federal de São Paulo, São Paulo, Brazil
Interests: neurobiology; tissue engineering; regenerative medicine

Special Issue Information

Dear Colleagues,

Neural regeneration, especially in the central nervous system, has always been a limiting factor in overcoming sequelae from stroke, traumatic brain injuries, and neurodegeneration caused by diseases such as Alzheimer’s and Parkinson’s. Brain injury sequelae are responsible for emotional, social, and financial impacts on millions of people around the globe. Recent advances in the discovery and development of new biomaterials have allowed the scientific community to explore the possibility of bioengineering neural tissue to repair the damaged brain, similar to what has been done in the past two decades for the peripheral nervous system. Besides the possibility of the regenerative use of bioengineered neural tissues, new biomaterials allow the development of neural-like tissues to study drug delivery to the brain, virus infections, and the cellular as well as molecular mechanisms of neurodegenerative disorders.

This Special Issue aims to highlight recent research on biomaterials in neural tissue engineering. The primary aim of this Special Issue is, but not limited to, to explore the use of biomaterials to fabricate neural tissues to be used as:

  1. In vitro models to study brain diseases.
  2. In vitro models for drug screening or drug repositioning.
  3. Bio patches for brain repair.

Aspects of the characteristics of biomaterials, such as their rigidity, permeability, integration into in vivo tissues, and others, will also be relevant to this Special Issue. Research on the effects of biomaterials on cell proliferation, migration, apoptosis, and fate induction is very relevant for the discussion regarding the use of biomaterials for neural tissue engineering.

We kindly invite the submission of original research and reviews for this Special Issue. 

We are looking forward to receiving your contribution.

Dr. Marimelia Porcionatto
Guest Editor

Manuscript Submission Information

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Keywords

  • biomaterials
  • neural tissue
  • bioengineering
  • 3D model
  • CNS diseases
  • neurodegeneration
  • drug screening
  • drug repositioning
  • regenerative medicine

Published Papers (1 paper)

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Research

22 pages, 8389 KiB  
Article
A Gelatin Methacrylate-Based Hydrogel as a Potential Bioink for 3D Bioprinting and Neuronal Differentiation
by Elisa Marozzi Cruz, Lucas Simões Machado, Laura Nicoleti Zamproni, Larissa Valdemarin Bim, Paula Scanavez Ferreira, Leonardo Alves Pinto, Luiz Antonio Pessan, Eduardo Henrique Backes and Marimélia Aparecida Porcionatto
Pharmaceutics 2023, 15(2), 627; https://doi.org/10.3390/pharmaceutics15020627 - 13 Feb 2023
Cited by 4 | Viewed by 2155
Abstract
Neuronal loss is the ultimate pathophysiologic event in central nervous system (CNS) diseases and replacing these neurons is one of the most significant challenges in regenerative medicine. Providing a suitable microenvironment for new neuron engraftment, proliferation, and synapse formation is a primary goal [...] Read more.
Neuronal loss is the ultimate pathophysiologic event in central nervous system (CNS) diseases and replacing these neurons is one of the most significant challenges in regenerative medicine. Providing a suitable microenvironment for new neuron engraftment, proliferation, and synapse formation is a primary goal for 3D bioprinting. Among the various biomaterials, gelatin methacrylate (GelMA) stands out due to its Arg-Gly-Asp (RGD) domains, which assure its biocompatibility and degradation under physiological conditions. This work aimed to produce different GelMA-based bioink compositions, verify their mechanical and biological properties, and evaluate their ability to support neurogenesis. We evaluated four different GelMA-based bioink compositions; however, when it came to their biological properties, incorporating extracellular matrix components, such as GeltrexTM, was essential to ensure human neuroprogenitor cell viability. Finally, GeltrexTM: 8% GelMA (1:1) bioink efficiently maintained human neuroprogenitor cell stemness and supported neuronal differentiation. Interestingly, this bioink composition provides a suitable environment for murine astrocytes to de-differentiate into neural stem cells and give rise to MAP2-positive cells. Full article
(This article belongs to the Special Issue Biomaterials for Neural Tissue Engineering)
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