Fighting Fungal Infections: Emerging Nanosystems Strategies
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 4372
Special Issue Editors
Interests: bioactive compounds; antitumor compounds; antimicrobial compounds; immunomodulation
Special Issues, Collections and Topics in MDPI journals
2. UCIBIO—Applied Molecular Biosciences Unit, MedTech—Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 050-313 Porto, Portugal
Interests: bioactive delivery systems; lipid-based nanosystems; hybrid nanosystems; controlled delivery; multifunctional nanosystems
Special Issues, Collections and Topics in MDPI journals
Interests: nanocarriers; nanotherapeutics; membrane model systems; ADMET profiling; biophysical techniques
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mycoses are a major threat affecting billions of people and causing more than 1.5 million deaths annually. The treatment of fungal infections is a challenge for both medical and scientific communities. The lack of selectivity, associated side effects, and the limited spectrum of antifungal agents, as well as the emergence of new virulent and drug-resistant fungi, justify the search for new drugs and the development of novel formulations. Nanosystems have gained prominence as alternatives to overcome the limitations of conventional formulations in the therapy and delivery of antifungal agents; these limitations include low permeation through tissues, limited aqueous solubility, and poor pharmacokinetics which lead to high doses and dosing frequency. Nanosystem-based formulations have emerged as an attractive option for overcoming pharmacological, pharmacokinetic, and toxicity issues associated with antifungal agents. Furthermore, the development of antifungal encapsulating technologies enables controlled drug release while protecting the active principle, preventing its off-target toxicity and degradation. Nanosystems can also have a synergistic effect with antifungals and may be used in the development of vaccines against fungal infections.
This Special Issue aims to present a collection of studies describing recent advances in the development of nanosystems approaches suited for antifungal therapy and prophylaxis, as well as those highlighting the benefits and drawbacks of nanoscale solutions when multiple routes of administration are considered (e.g., oral, intravenous, pulmonary, skin, vaginal, ocular).
Dr. Fatima Cerqueira
Dr. Carla M. Lopes
Dr. Marlene Lucio
Guest Editors
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Keywords
- antifungal agents
- lipid-based nanosystems
- polymer-based nanosystems
- inorganic nanosystems
- hybrid nanosystems
- vaccine-based nanosystems
