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Pharmaceutics
Special Issues
Green Chemistry and Green Engineering in Current and Novel Pharmaceutical...
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Green Chemistry and Green Engineering in Current and Novel Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 6095

Special Issue Editors

Prof. Dr. Senka Vidovic

E-Mail Website
Guest Editor
Faculty of Technology Novi Sad, Department of Biotechnology and Pharmaceutical Engineering, University of Novi Sad, Novi Sad, Serbia
Interests: extraction; high pressure extraction; spray drying; powders; medicinal plants
Prof. Dr. Ana Rita C. Duarte

E-Mail Website
Guest Editor
LAQV-REQUIMTE, Chemistry Department, Faculty of Science and Technology, Nova University of Lisbon, 2829-516 Caparica, Portugal
Interests: biomaterials; polymers; chemical engineering; tissue engineering; nanomaterials; materials; materials engineering; polymerization
Prof. Dr. Anastasia Detsi

E-Mail Website
Guest Editor
Laboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, 15780 Zografou, Greece
Interests: organic chemistry; green chemistry; medicinal chemistry; nanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is related to the current and novel applications of green chemistry and green engineering in the field of pharmaceutics. Twelve green principles developed during the 20th century inspired researchers worldwide to investigate and make efforts in realizing new knowledge and new inventions, designs and applications of products and processes fitting the concept of green chemistry and with the potential to be implemented by the modern pharmaceutical and cometic industry. The evidence shows that steps forward in industrial application have been made, but more green innovations are needed to push it more intensively. The same task has brought together scientists and industry in the new network framed in the COST Action 18224—Greenering—Green Chemical Engineering Network towards Upscaling Sustainable Processes. In accordance with that, this Special Issue welcomes the submission of original research manuscripts or reviews concerning the development of novel processes (high-pressure processes, processes applying green solvents, green particle engineering and green synthesis) and pharmaceutic products with respect to the green concept.

Prof. Dr. Senka Vidovic
Prof. Dr. Ana Rita C. Duarte
Prof. Dr. Anastasia Detsi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green chemistry
  • green processes
  • green solvents
  • green synthesis
  • high-pressure processes
  • particle engineering
  • PGSS
  • SAS
  • mechanochemistry
  • ionic liquids
  • DES
  • supercritical fluids

Published Papers (2 papers)

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Research

15 pages, 15123 KiB  
Article
Green by Design: Convergent Synthesis, Computational Analyses, and Activity Evaluation of New FXa Inhibitors Bearing Peptide Triazole Linking Units
by Diego F. Rodríguez, Francisca Durán-Osorio, Yorley Duarte, Pedro Olivares, Yanina Moglie, Kamal Dua and Flavia C. Zacconi
Pharmaceutics 2022, 14(1), 33; https://doi.org/10.3390/pharmaceutics14010033 - 24 Dec 2021
Cited by 11 | Viewed by 3143
Abstract
Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, we wish to report a green synthesis of new pharmaceutically active peptide [...] Read more.
Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, we wish to report a green synthesis of new pharmaceutically active peptide triazoles as potent factor Xa inhibitors, an important drug target associated with the treatment of diverse cardiovascular diseases. The new inhibitors were synthesized in three steps, featuring cycloaddition reactions (high atom economy), microwave-assisted organic synthesis (energy efficiency), and copper nanoparticle catalysis, thus featuring Earth-abundant metals. The molecules obtained showed FXa inhibition, with IC50-values as low as 17.2 μM and no associated cytotoxicity in HEK293 and HeLa cells. These results showcase the environmental potential and chemical implications of the applied methodologies for the development of new molecules with pharmacological potential. Full article
(This article belongs to the Special Issue Green Chemistry and Green Engineering in Current and Novel Pharmaceutical Applications)
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16 pages, 2453 KiB  
Article
Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs
by Ana Roda, Alexandre Paiva and Ana Rita C. Duarte
Pharmaceutics 2021, 13(10), 1620; https://doi.org/10.3390/pharmaceutics13101620 - 05 Oct 2021
Cited by 6 | Viewed by 2012
Abstract
Most nonsteroidal anti-inflammatory drugs (NSAIDs) present poor aqueous solubility, impairing their efficiency in physiological media. In this context, Low Transition Temperature Mixtures (LTTMs) are a promising platform to overcome drugs’ poor solubility, forming therapeutic liquid formulations. In this work, the LTTMs of citric [...] Read more.
Most nonsteroidal anti-inflammatory drugs (NSAIDs) present poor aqueous solubility, impairing their efficiency in physiological media. In this context, Low Transition Temperature Mixtures (LTTMs) are a promising platform to overcome drugs’ poor solubility, forming therapeutic liquid formulations. In this work, the LTTMs of citric acid:L-arginine:water (C:A:W) and glycerol:sorbitol (G:S) were studied in terms of their features and assessed in terms of their ability to increase the solubility of six NSAIDs in physiological media. The physicochemical properties of LTTMs were characterized by state-of-art techniques commonly used for these systems. The cytotoxicity of G:S was also evaluated in L929 mouse fibroblasts and the viscosity, polarity, and pH properties of the studied mixtures were related to the solubility of NSAIDs. The pH and polarity were the parameters that most influenced the drugs’ solubility. Ibuprofen, naproxen, ketoprofen, indomethacin, and flurbiprofen did not present any solubility improvement in the formulations tested. However, concentrated mixtures of C:A:W or G:S in the physiologic-mimicked media (PBS) rendered a celecoxib solubility 4 and 5 times higher than PBS, respectively. These therapeutic liquid formulations of celecoxib in C:A:W or G:S can be a promising tool to increase celecoxib’s therapeutic efficiency in local applications. Full article
(This article belongs to the Special Issue Green Chemistry and Green Engineering in Current and Novel Pharmaceutical Applications)
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