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Pharmaceutics
Special Issues
Drug Delivery for Wound Healing: Recent Advances
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Drug Delivery for Wound Healing: Recent Advances

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 9340

Special Issue Editor

Prof. Dr. Marco Romanelli

E-Mail Website
Guest Editor
Dermatology Unit, Dermatology Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Interests: chronic wounds; drug delivery; wound healing; tissue engineering; tissue repair

Special Issue Information

Dear Colleagues,

It gives me great pleasure to announce the launch of a new Special Issue on “Drug Delivery in Wound Healing: Recent Advances”, a research area which is both topical and of great significance in our field and which focuses on new scaffold materials and new drugs covering several phases of wound repair discovered in the last five years.

Original contributions from lab investigations or even preclinical data are invited. The aim of this Special Issue is to collect highly cited papers and stimulate more scientists, wound professionals, and industrial partners to invest in this area.

I look forward to your contribution.

Prof. Dr. Marco Romanelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • chronic wounds
  • scaffold materials
  • drug delivery
  • tissue engineering

Published Papers (3 papers)

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Research

13 pages, 4811 KiB  
Article
Plasminogen-Loaded Fibrin Scaffold as Drug Delivery System for Wound Healing Applications
by Tamer Al Kayal, Marianna Buscemi, Aida Cavallo, Ilenia Foffa, Giorgio Soldani and Paola Losi
Pharmaceutics 2022, 14(2), 251; https://doi.org/10.3390/pharmaceutics14020251 - 21 Jan 2022
Cited by 11 | Viewed by 2779
Abstract
Plasminogen is a protein involved in intravascular and extravascular fibrinolysis, as well as in wound healing, cell migration, tissue formation and angiogenesis. In recent years its role in healing of tympanic perforations has been demonstrated in plasminogen deficient mice. The aim of this [...] Read more.
Plasminogen is a protein involved in intravascular and extravascular fibrinolysis, as well as in wound healing, cell migration, tissue formation and angiogenesis. In recent years its role in healing of tympanic perforations has been demonstrated in plasminogen deficient mice. The aim of this work was to fabricate a fibrin-based drug delivery system able to provide a local and sustained release of plasminogen at the wound site. Initially, the biological activity of plasminogen was evaluated by in vitro experiments on cell cultures. A metabolic assay (MTT) was carried out on L929 mouse fibroblast to determine the concentration that does not affect cell viability, which turned out to be 64 nM. The effect of plasminogen on cell migration was evaluated through a scratch test on human keratinocytes: cells treated with 64 nM plasminogen showed faster scratch closure than in complete medium. Fibrin scaffold loaded with plasminogen was fabricated by a spray process. SEM analysis showed the typical nano-fibrillar structure of a fibrin scaffold. Tensile tests highlighted significantly higher value of the ultimate stress and strain of fibrin scaffold with respect to fibrin clot. The in-vitro release kinetic showed an initial plasminogen burst, after that the release slowed, reaching a plateau at 7 days. Plasminogen-loaded fibrin scaffold applied in full-thickness diabetic mouse lesions showed a significantly higher closure rate at 14 days than scaffold used as a reference material. Histological analysis demonstrated an improved reepithelization and collagen deposition in granulation tissue in mouse treated with plasminogen-loaded fibrin scaffold in comparison to unloaded fibrin scaffold. The obtained results demonstrated the suitability of the fibrin scaffold loaded with plasminogen as drug delivery system and suggest its use in wound healing applications, such as for the treatment of chronic diabeticulcers. Full article
(This article belongs to the Special Issue Drug Delivery for Wound Healing: Recent Advances)
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14 pages, 13601 KiB  
Article
Physico-Chemical Characterization and In Vitro Biological Evaluation of a Bionic Hydrogel Based on Hyaluronic Acid and l-Lysine for Medical Applications
by Giuseppe Alonci, Roberto Mocchi, Sabrina Sommatis, Maria Chiara Capillo, Elsa Liga, Agata Janowska, Lidia Nachbaur and Nicola Zerbinati
Pharmaceutics 2021, 13(8), 1194; https://doi.org/10.3390/pharmaceutics13081194 - 3 Aug 2021
Cited by 7 | Viewed by 2359
Abstract
Hyaluronic acid (HA) is an endogenous polysaccharide, whose hydrogels have been used in medical applications for decades. Here, we present a technology platform for stabilizing HA with a biocrosslinker, the amino acid L-lysine, to manufacture bionic hydrogels for regenerative medicine. We synthetized bionic [...] Read more.
Hyaluronic acid (HA) is an endogenous polysaccharide, whose hydrogels have been used in medical applications for decades. Here, we present a technology platform for stabilizing HA with a biocrosslinker, the amino acid L-lysine, to manufacture bionic hydrogels for regenerative medicine. We synthetized bionic hydrogels with tailored composition with respect to HA concentration and degree of stabilization depending on the envisaged medical use. The structure of the hydrogels was assessed by microscopy and rheology, and the resorption behavior through enzymatic degradation with hyaluronidase. The biological compatibility was evaluated in vitro with human dermal fibroblast cell lines. HA bionic hydrogels stabilized with lysine show a 3D network structure, with a rheological profile that mimics biological matrixes, as a harmless biodegradable substrate for cell proliferation and regeneration and a promising candidate for wound healing and other medical applications. Full article
(This article belongs to the Special Issue Drug Delivery for Wound Healing: Recent Advances)
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16 pages, 2843 KiB  
Article
Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications
by Clara López-Iglesias, Cristina Quílez, Joana Barros, Diego Velasco, Carmen Alvarez-Lorenzo, José L. Jorcano, Fernando J. Monteiro and Carlos A. García-González
Pharmaceutics 2020, 12(9), 870; https://doi.org/10.3390/pharmaceutics12090870 - 12 Sep 2020
Cited by 20 | Viewed by 3447
Abstract
The delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound complications. In this work, solid lipid microparticles (SLMPs) loaded with lidocaine hydrochloride (LID) were processed and the formulation was [...] Read more.
The delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound complications. In this work, solid lipid microparticles (SLMPs) loaded with lidocaine hydrochloride (LID) were processed and the formulation was evaluated regarding its ability to deliver the drug at the wound site and through the skin barrier. The SLMPs of glyceryl monostearate (GMS) were prepared with different LID contents (0, 1, 2, 4, and 10 wt.%) using the solvent-free and one-step PGSS (Particles from Gas-Saturated Solutions) technique. PGSS exploits the use of supercritical CO2 (scCO2) as a plasticizer for lipids and as pressurizing agent for the atomization of particles. The SLMPs were characterized in terms of shape, size, and morphology (SEM), physicochemical properties (ATR-IR, XRD), and drug content and release behavior. An in vitro test for the evaluation of the influence of the wound environment on the LID release rate from SLMPs was studied using different bioengineered human skin substitutes obtained by 3D-bioprinting. Finally, the antimicrobial activity of the SLMPs was evaluated against three relevant bacteria in wound infections (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa). SLMPs processed with 10 wt.% of LID showed a remarkable performance to provide effective doses for pain relief and preventive infection effects. Full article
(This article belongs to the Special Issue Drug Delivery for Wound Healing: Recent Advances)
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