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Pharmaceutics
Special Issues
Polymeric Nanoparticles for Cancer Therapy and Biomedical-Related Application
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Polymeric Nanoparticles for Cancer Therapy and Biomedical-Related Application

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (10 December 2022) | Viewed by 7878

Special Issue Editors

Dr. Giovanni Dal Poggetto

E-Mail Website
Guest Editor
Institute for Polymers, Composites and Biomaterials (IPCB) of National Research Council (CNR), via Campi Flegrei 34, 80078 Pozzuoli, Italy
Interests: nanoparticles; polymer synthesis; drug delivery; nanoparticles surface properties; NMR; gel permeation chromatography
Dr. Paola Laurienzo

E-Mail Website
Guest Editor
Institute for Polymers, Composites and Biomaterials, CNR, via Campi Flegrei 34, 80078 Pozzuoli, Italy
Interests: macromolecular chemistry; natural polysaccharides; drug delivery; nanoparticles surface modification; active targeting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

among drug delivery systems, polymeric nanoparticles are one of the most versatile approach to several aspects in anticancer therapy: from enhancing bioavailability of drugs through specific delivery at the target site, to increase therapeutical efficacy in cancer treatment and promoting drug penetration through biological membranes. Moreover, the possibility of a combined therapy could also be accomplished combining different drugs or different treatments. The flexibility of polymers, natural or from synthesis, makes them potentially ideal for fulfilling the requirements of each particular system. Polymeric nanoparticles characteristics can be fine-tuned to enhance stability, release, targeting and other surface properties.

Surface properties and size are strategic to allow polymeric nanoparticles to circulate in the body and pass-through biological barriers to target the site of interest.

In this Special Issue, we invite submissions investigating innovation and novelty in design, methods and applications of polymeric nanoparticles in drug delivery for cancer therapy. 

Dr. Giovanni Dal Poggetto
Dr. Paola Laurienzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric nanoparticles
  • cancer therapy
  • targeting
  • bioapplication
  • nanoparticle characterization

Published Papers (4 papers)

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Research

29 pages, 15195 KiB  
Article
Cannabimimetic N-Stearoylethanolamine as “Double-Edged Sword” in Anticancer Chemotherapy: Proapoptotic Effect on Tumor Cells and Suppression of Tumor Growth versus Its Bio-Protective Actions in Complex with Polymeric Carrier on General Toxicity of Doxorubicin In Vivo
by Rostyslav Panchuk, Nadiya Skorokhyd, Vira Chumak, Lilya Lehka, Halyna Kosiakova, Tetyana Horid’ko, Iehor Hudz, Nadiya Hula, Anna Riabtseva, Nataliya Mitina, Alexander Zaichenko, Petra Heffeter, Walter Berger and Rostyslav Stoika
Pharmaceutics 2023, 15(3), 835; https://doi.org/10.3390/pharmaceutics15030835 - 03 Mar 2023
Cited by 1 | Viewed by 1382
Abstract
This study reports a dose-dependent pro-apoptotic action of synthetic cannabimimetic N-stearoylethanolamine (NSE) on diverse cancer cell lines, including multidrug-resistant models. No antioxidant or cytoprotective effects of NSE were found when it was applied together with doxorubicin. A complex of NSE with the [...] Read more.
This study reports a dose-dependent pro-apoptotic action of synthetic cannabimimetic N-stearoylethanolamine (NSE) on diverse cancer cell lines, including multidrug-resistant models. No antioxidant or cytoprotective effects of NSE were found when it was applied together with doxorubicin. A complex of NSE with the polymeric carrier poly(5-(tert-butylperoxy)-5-methyl-1-hexen-3-yn-co-glycidyl methacrylate)-graft-PEG was synthesized. Co-immobilization of NSE and doxorubicin on this carrier led to a 2-10-fold enhancement of the anticancer activity, particularly, against drug-resistant cells overexpressing ABCC1 and ABCB1. This effect might be caused by accelerated nuclear accumulation of doxorubicin in cancer cells, which led to the activation of the caspase cascade, revealed by Western blot analysis. The NSE-containing polymeric carrier was also able to significantly enhance the therapeutic activity of doxorubicin in mice with implanted NK/Ly lymphoma or L1210 leukemia, leading to the complete eradication of these malignancies. Simultaneously, loading to the carrier prevented doxorubicin-induced elevation of AST and ALT as well as leukopenia in healthy Balb/c mice. Thus, a unique bi-functionality of the novel pharmaceutical formulation of NSE was revealed. It enhanced doxorubicin-induced apoptosis in cancer cells in vitro and promoted its anticancer activity against lymphoma and leukemia models in vivo. Simultaneously, it was very well tolerated preventing frequently observed doxorubicin-associated adverse effects. Full article
(This article belongs to the Special Issue Polymeric Nanoparticles for Cancer Therapy and Biomedical-Related Application)
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18 pages, 3034 KiB  
Article
Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity
by Alexander Yu. Rybkin, Svetlana V. Kurmaz, Elizaveta A. Urakova, Natalia V. Filatova, Lev R. Sizov, Alexey V. Kozlov, Mikhail O. Koifman and Nikolai S. Goryachev
Pharmaceutics 2023, 15(1), 273; https://doi.org/10.3390/pharmaceutics15010273 - 12 Jan 2023
Cited by 4 | Viewed by 1418
Abstract
A series of nanoparticles (NPs) with a hydrodynamic radius from 20 to 100 nm in PBS was developed over the solubilization of hydrophobic dye methyl pheophorbide a (chlorin e6 derivative) by amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates. Photophysical properties and biological activity [...] Read more.
A series of nanoparticles (NPs) with a hydrodynamic radius from 20 to 100 nm in PBS was developed over the solubilization of hydrophobic dye methyl pheophorbide a (chlorin e6 derivative) by amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates. Photophysical properties and biological activity of the NPs aqueous solution were studied. It was found that the dye encapsulated in the copolymers is in an aggregated state. However, its aggregation degree decreases sharply, and singlet oxygen quantum yield and the fluorescence signal increase upon the interaction of these NPs with model biological membranes—liposomes or components of a tissue homogenate. The phototoxic effect of NPs in HeLa cells exceeds by 1.5–2 times that of the reference dye chlorin e6 trisodium salt—one of the most effective photosensitizers used in clinical practice. It could be explained by the effective release of the hydrophobic photosensitizer from the NPs into biological structures. The demonstrated approach can be used not only for the encapsulation of hydrophobic photosensitizers for PDT but also for other drugs, and N-vinylpyrrolidone amphiphilic copolymers show promising potential as a modern platform for the design of targeted delivery vehicles. Full article
(This article belongs to the Special Issue Polymeric Nanoparticles for Cancer Therapy and Biomedical-Related Application)
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14 pages, 2801 KiB  
Article
Effects of Particle Geometry for PLGA-Based Nanoparticles: Preparation and In Vitro/In Vivo Evaluation
by Meryem Kaplan, Kıvılcım Öztürk, Süleyman Can Öztürk, Ece Tavukçuoğlu, Güneş Esendağlı and Sema Calis
Pharmaceutics 2023, 15(1), 175; https://doi.org/10.3390/pharmaceutics15010175 - 03 Jan 2023
Cited by 9 | Viewed by 2693
Abstract
The physicochemical properties (size, shape, zeta potential, porosity, elasticity, etc.) of nanocarriers influence their biological behavior directly, which may result in alterations of the therapeutic outcome. Understanding the effect of shape on the cellular interaction and biodistribution of intravenously injected particles could have [...] Read more.
The physicochemical properties (size, shape, zeta potential, porosity, elasticity, etc.) of nanocarriers influence their biological behavior directly, which may result in alterations of the therapeutic outcome. Understanding the effect of shape on the cellular interaction and biodistribution of intravenously injected particles could have fundamental importance for the rational design of drug delivery systems. In the present study, spherical, rod and elliptical disk-shaped PLGA nanoparticles were developed for examining systematically their behavior in vitro and in vivo. An important finding is that the release of the encapsulated human serum albumin (HSA) was significantly higher in spherical particles compared to rod and elliptical disks, indicating that the shape can make a difference. Safety studies showed that the toxicity of PLGA nanoparticles is not shape dependent in the studied concentration range. This study has pioneering findings on comparing spherical, rod and elliptical disk-shaped PLGA nanoparticles in terms of particle size, particle size distribution, colloidal stability, morphology, drug encapsulation, drug release, safety of nanoparticles, cellular uptake and biodistribution. Nude mice bearing non-small cell lung cancer were treated with 3 differently shaped nanoparticles, and the accumulation of nanoparticles in tumor tissue and other organs was not statistically different (p > 0.05). It was found that PLGA nanoparticles with 1.00, 4.0 ± 0.5, 7.5 ± 0.5 aspect ratios did not differ on total tumor accumulation in non-small cell lung cancer. Full article
(This article belongs to the Special Issue Polymeric Nanoparticles for Cancer Therapy and Biomedical-Related Application)
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18 pages, 5610 KiB  
Article
Anti-Proliferative Potential of Quercetin Loaded Polymeric Mixed Micelles on Rat C6 and Human U87MG Glioma Cells
by Sathishbabu Paranthaman, Chinnappa A. Uthaiah, Riyaz Ali M. Osmani, Umme Hani, Mohammed Ghazwani, Ali H. Alamri, Adel Al Fatease, SubbaRao V. Madhunapantula and Devegowda Vishkante Gowda
Pharmaceutics 2022, 14(8), 1643; https://doi.org/10.3390/pharmaceutics14081643 - 06 Aug 2022
Cited by 11 | Viewed by 1753
Abstract
Quercetin (Qu) is a natural flavonoid present in many commonly consumed food items and is also identified as a potential anticancer agent. The present study evaluates the Qu-loaded polymeric mixed micelles (Qu-PMMs) against C6 and U87MG glioma cell lines. The Box–Behnken Design (BBD) [...] Read more.
Quercetin (Qu) is a natural flavonoid present in many commonly consumed food items and is also identified as a potential anticancer agent. The present study evaluates the Qu-loaded polymeric mixed micelles (Qu-PMMs) against C6 and U87MG glioma cell lines. The Box–Behnken Design (BBD) was employed to study the influence of independent variables such as Soluplus, Vitamin-E polyethyleneglycol-1000 succinate (E-TPGS), and poloxamer 407 concentrations on dependent variables including particle size (PS), polydispersity index (PDI), and percentage entrapment efficiency (%EE) of the prepared Qu-PMMs. The Qu-PMMs were further characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Scanning Electron Microscope (SEM), and were assessed for in vitro drug release, effect on cell viability, migration, cellular uptake, and apoptosis assays. The PS, PDI, and % EE of the optimized PMMs were 107.16 ± 1.06 nm, 0.236 ± 0.053, and 77.46 ± 1.94%, respectively. The FTIR and XRD revealed that the Qu was completely entrapped inside the PMMs. The SEM analysis confirmed the spherical shape of micelles. The in vitro cell viability study showed that the Qu-PMMs had 1.7 times higher cytotoxicity against C6 and U87MG cells than Qu pure drug (Qu-PD). Furthermore, Qu-PMMs demonstrated superior cellular uptake, inhibited migration, and induced apoptosis when tested against C6 and U87MG cells than pure Qu. Thus, the polymeric mixed micelle (PMMs) enhanced the therapeutic effect of Qu and can be considered an effective therapeutic strategy to treat Glioma. Full article
(This article belongs to the Special Issue Polymeric Nanoparticles for Cancer Therapy and Biomedical-Related Application)
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