3D Printing of Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1216

Special Issue Editor


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Guest Editor
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia
Interests: poorly soluble drugs; solid dispersions; amorphous formulation; nanocrystals; experimental design; 3D printing
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Special Issue Information

Dear Colleagues,

Disease treatment is still largely based on a so-called one-size-fits-all approach, in which similar drug doses are prescribed to a large number of patients without taking into account the interindividual differences between them. In addition to tailoring therapy to the anatomical and physiological characteristics of individual patients, the acceptability of therapy to individual patients in terms of the dosing frequency, the number of drugs in therapy, and the appearance, size, colour, taste and textural properties of the dosage form is becoming increasingly important. The application of 3D printing technology offers practitioners the ability to produce small batches of drug delivery systems customized to individual patient characteristics and preferences, and provide tailored drug release. Since the FDA approved the first 3D-printed drug Spritam®, interest in the pharmaceutical application of 3D printing has been expanding in both academia and industry, leading to a number of publications and the appearance of the first 3D printers specifically designed for pharmaceutical purposes. However, further intensive research is required, and should focus in particular on the material properties and parameters of the printing process; these should be controlled in order to obtain a consistent product. A less stringent regulatory approach compared to conventional pharmaceutical production is certainly needed for the implementation of 3D printing at the point-of-care, where the benefits of this technology can be best exploited.

This Special Issue welcomes both original and review articles that address recent advances and future directions in the 3D printing of drug delivery systems.

Dr. Djordje Medarevic
Guest Editor

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Keywords

  • additive manufacturing
  • 3D printing
  • personalized drug delivery systems
  • tailored drug release

Published Papers (1 paper)

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Research

13 pages, 2422 KiB  
Article
3D Screen Printing Offers Unprecedented Anticounterfeiting Strategies for Oral Solid Dosage Forms Feasible for Large Scale Production
by Nicolle Schwarz, Marcel Enke, Franka V. Gruschwitz, Daniela Winkler, Susanne Franzmann, Lisa Jescheck, Felix Hanf and Achim Schneeberger
Pharmaceutics 2024, 16(3), 368; https://doi.org/10.3390/pharmaceutics16030368 - 05 Mar 2024
Viewed by 901
Abstract
A threat to human health in developed and, in particular, in developing countries, counterfeit medicines represent the largest identified fraud market worldwide. 3D screen printing (3DSP), an additive manufacturing technology that enables large-scale production, offers unique opportunities to combat counterfeit drugs. One such [...] Read more.
A threat to human health in developed and, in particular, in developing countries, counterfeit medicines represent the largest identified fraud market worldwide. 3D screen printing (3DSP), an additive manufacturing technology that enables large-scale production, offers unique opportunities to combat counterfeit drugs. One such possibility is the generation of oral dosage forms with a distinct colored inner structure that becomes visible upon breakage and cannot be copied with conventional manufacturing methods. To illustrate this, we designed tablets containing a blue cross. Owing to paste properties and the limited dimensions of the cross, the production process was chosen to be continuous, involving two screen and paste changes. The two pastes (tablet body, cross) were identical except for the blue color of the latter. This ensured the build-up and mechanical stability of the resulting tablets in a mass production environment. The ensuing tablets were found to be uniform in weight and size and to comply with regulatory requirements for hardness, friability, and disintegration time (immediate release). Moreover, all tablets exhibited the covert anticounterfeit feature. The study delivers a proof-of-concept for incorporating complex structures into tablets using 3DSP and showcases the power of the technology offering new avenues for combating counterfeit drugs. Full article
(This article belongs to the Special Issue 3D Printing of Drug Delivery Systems)
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