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Journals
Pharmaceutics
Special Issues
New Pharmaceutical Targets to Counteract Chronic Inflammation
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New Pharmaceutical Targets to Counteract Chronic Inflammation

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 414

Special Issue Editors

Dr. Maria De Fenza

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Guest Editor
Department of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Naples, Italy
Interests: organic synthesis; biomimetic agents; uPA-uPAR system; chronic inflammation; retinal diseases
Prof. Vincenzo Pavone

E-Mail Website
Guest Editor
Department of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Naples, Italy
Interests: bioinorganic chemistry; artificial metalloenzymes; bioactive peptides; angiogenesis; chronic inflammation; uPA-uPAR system
Dr. Daniele D'Alonzo

E-Mail Website
Guest Editor
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, via Cintia, 80126 Naples, Italy
Interests: biomimetic agents; artificial metalloenzymes; organic synthesis; drug discovery; angiogenesis; chronic inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Giuseppe Castellano

E-Mail Website
Guest Editor
1. Department of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2. Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Interests: chronic kidney disease (CKD); chronic inflammation; glomerulonephritis; kidney transplantation; acute kidney disease (AKI)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammation is a protective response of organisms to harmful stimuli including pathogens, damaged cells, and toxic compounds. While finely regulated in a healthy organism, uncontrolled inflammation may become chronic, contributing to the onset of a large number of pathological conditions, spanning from cancer to autoimmune disorders, from diabetes-related complications to infections, from kidney to ocular diseases, and to a variety of age-related degenerative conditions. For many of these pathologies, therapeutic intervention is frequently absent or inadequate. Over the last years, molecular understanding of the mechanisms and signalling pathways leading to chronic inflammation has enabled the identification of new, general and effective pharmaceutic targets (proteolytic enzymes, Toll-like receptors, inflammatory factors, growth factors, and inflammatory metabolites) to be exploited for innovative treatments of inflammatory diseases.

The goal of this Special Issue is to highlight and collate scientific publications and reviews on interesting pharmaceutical studies (regarding the identification of new pharmaceutical targets, innovative pharmaceutic treatments and formulations, and insights into the mechanisms of therapeutic drugs in chronic inflammatory diseases) that aim to tackle and cure diseases characterized by chronic inflammation.

Dr. Maria De Fenza
Prof. Vincenzo Pavone
Dr. Daniele D'Alonzo
Dr. Giuseppe Castellano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dysregulated chemotaxis
  • chronic inflammation
  • ocular diseases
  • focal segmental glomerulosclerosis
  • acute kidney disease
  • new pharmaceutical targets
  • innovative pharmaceutic treatments and formulations

Published Papers (1 paper)

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Research

13 pages, 539 KiB  
Article
The Role of a Cholecystokinin Receptor Antagonist in the Management of Chronic Pancreatitis: A Phase 1 Trial
by Victor Ciofoaia, Wenqiang Chen, Bakain W. Tarek, Martha Gay, Narayan Shivapurkar and Jill P. Smith
Pharmaceutics 2024, 16(5), 611; https://doi.org/10.3390/pharmaceutics16050611 - 30 Apr 2024
Viewed by 258
Abstract
Chronic pancreatitis (CP) is a rare but debilitating condition with an 8-fold increased risk of developing pancreatic cancer. In addition to the symptoms that come from the loss of endocrine and exocrine function in CP, the management of chronic pain is problematic. We [...] Read more.
Chronic pancreatitis (CP) is a rare but debilitating condition with an 8-fold increased risk of developing pancreatic cancer. In addition to the symptoms that come from the loss of endocrine and exocrine function in CP, the management of chronic pain is problematic. We previously showed that the CCK-receptor antagonist called proglumide could decrease inflammation, acinar-ductal metaplasia, and fibrosis in murine models of CP. We hypothesized that proglumide would be safe and diminish pain caused by CP. A Phase 1 open-labeled safety study was performed in subjects with clinical and radiographic evidence of CP with moderate to severe pain. After a 4-week observation period, the subjects were treated with proglumide in 400 mg capsules three times daily (1200 mg per day) by mouth for 12 weeks, followed by 4 weeks of observation after discontinuation for safety. The results of three pain surveys (Numeric Rating Scale, COMPAT-SF, and NIH PROMIS) showed that the patients had significantly less pain after 12 weeks of proglumide compared to the pre-treatment observation phase. Of the eight subjects in this study, two experienced nausea and diarrhea with proglumide. These side effects resolved in one subject with doses reduced to 800 mg per day. No abnormalities were noted in the blood chemistries. A blood microRNA blood biomarker panel that corresponded to pancreatic inflammation and fibrosis showed significant improvement. We conclude that proglumide is safe and well tolerated in most subjects with CP at a dose of 1200 mg per day. Furthermore, proglumide therapy may have a beneficial effect by decreasing pain associated with CP. Full article
(This article belongs to the Special Issue New Pharmaceutical Targets to Counteract Chronic Inflammation)
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