New Pharmaceutical Targets to Counteract Chronic Inflammation

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 20 April 2024 | Viewed by 35

Special Issue Editors

Dr. Maria De Fenza
E-Mail Website
Guest Editor
Department of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Naples, Italy
Interests: organic synthesis; biomimetic agents; uPA-uPAR system; chronic inflammation; retinal diseases
Prof. Vincenzo Pavone
E-Mail Website
Guest Editor
Department of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Naples, Italy
Interests: bioinorganic chemistry; artificial metalloenzymes; bioactive peptides; angiogenesis; chronic inflammation; uPA-uPAR system
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, via Cintia, 80126 Naples, Italy
Interests: biomimetic agents; artificial metalloenzymes; organic synthesis; drug discovery; angiogenesis; chronic inflammation
Special Issues, Collections and Topics in MDPI journals
1. Department of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2. Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Interests: chronic kidney disease (CKD); chronic inflammation; glomerulonephritis; kidney transplantation; acute kidney disease (AKI)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammation is a protective response of organisms to harmful stimuli including pathogens, damaged cells, and toxic compounds. While finely regulated in a healthy organism, uncontrolled inflammation may become chronic, contributing to the onset of a large number of pathological conditions, spanning from cancer to autoimmune disorders, from diabetes-related complications to infections, from kidney to ocular diseases, and to a variety of age-related degenerative conditions. For many of these pathologies, therapeutic intervention is frequently absent or inadequate. Over the last years, molecular understanding of the mechanisms and signalling pathways leading to chronic inflammation has enabled the identification of new, general and effective pharmaceutic targets (proteolytic enzymes, Toll-like receptors, inflammatory factors, growth factors, and inflammatory metabolites) to be exploited for innovative treatments of inflammatory diseases.

The goal of this Special Issue is to highlight and collate scientific publications and reviews on interesting pharmaceutical studies (regarding the identification of new pharmaceutical targets, innovative pharmaceutic treatments and formulations, and insights into the mechanisms of therapeutic drugs in chronic inflammatory diseases) that aim to tackle and cure diseases characterized by chronic inflammation.

Dr. Maria De Fenza
Prof. Vincenzo Pavone
Dr. Daniele D'Alonzo
Dr. Giuseppe Castellano
Guest Editors

Manuscript Submission Information

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Keywords

  • dysregulated chemotaxis
  • chronic inflammation
  • ocular diseases
  • focal segmental glomerulosclerosis
  • acute kidney disease
  • new pharmaceutical targets
  • innovative pharmaceutic treatments and formulations

Published Papers

This special issue is now open for submission.
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