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Pharmaceutics
Special Issues
Pharmaceutical and Biotechnological Applications of Chitosan-Based Nanomaterials
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Pharmaceutical and Biotechnological Applications of Chitosan-Based Nanomaterials

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: closed (16 March 2023) | Viewed by 11780

Special Issue Editor

Prof. Dr. Ibrahim Abdullah Alsarra

E-Mail Website
Guest Editor
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Interests: pharmaceutical biotechnology; formulation development; targeted drug delivery; biosimilars; cancer research

Special Issue Information

Dear Colleagues,

It is my great privilege and pleasure to invite you to contribute to this Special Issue on Pharmaceutical and Biotechnological Applications of Chitosan-Based Nanomaterials. Chitosan is a biodegradable and biocompatible polymer that is regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Based on the versatility of chitosan, it has many potential applications in drug delivery via the GIT, nasal, and pulmonary routes. Chitosan nanoparticles can effectively deliver drugs at specific sites by retaining the drug locally to permit an extended time for drug absorption.  The focus of this Special Issue is exclusively dedicated to chitosan-based nanoparticles used for various pharmaceutical and biotechnological applications in drug delivery.

Prof. Dr. Ibrahim Abdullah Alsarra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chitosan
  • oral drug delivery
  • nanomaterials
  • biotechnological applications
  • biopolymer
  • polymeric nanoparticles

Published Papers (2 papers)

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Review

22 pages, 1618 KiB  
Review
Chitosan-Based Nanoparticles for Nucleic Acid Delivery: Technological Aspects, Applications, and Future Perspectives
by Maria Karayianni, Theodore Sentoukas, Athanasios Skandalis, Natassa Pippa and Stergios Pispas
Pharmaceutics 2023, 15(7), 1849; https://doi.org/10.3390/pharmaceutics15071849 - 29 Jun 2023
Cited by 8 | Viewed by 1928
Abstract
Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is an abundant carbohydrate found mainly in the shells of various marine and terrestrial (micro)organisms. Chitosan has been extensively used to construct nanoparticles (NPs), which are biocompatible, biodegradable, non-toxic, easy [...] Read more.
Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is an abundant carbohydrate found mainly in the shells of various marine and terrestrial (micro)organisms. Chitosan has been extensively used to construct nanoparticles (NPs), which are biocompatible, biodegradable, non-toxic, easy to prepare, and can function as effective drug delivery systems. Moreover, chitosan NPs have been employed in gene and vaccine delivery, as well as advanced cancer therapy, and they can also serve as new therapeutic tools against viral infections. In this review, we summarize the most recent developments in the field of chitosan-based NPs intended as nucleic acid delivery vehicles and gene therapy vectors. Special attention is given to the technological aspects of chitosan complexes for nucleic acid delivery. Full article
(This article belongs to the Special Issue Pharmaceutical and Biotechnological Applications of Chitosan-Based Nanomaterials)
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69 pages, 17242 KiB  
Review
Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications
by Nimeet Desai, Dhwani Rana, Sagar Salave, Raghav Gupta, Pranav Patel, Bharathi Karunakaran, Amit Sharma, Jyotsnendu Giri, Derajram Benival and Nagavendra Kommineni
Pharmaceutics 2023, 15(4), 1313; https://doi.org/10.3390/pharmaceutics15041313 - 21 Apr 2023
Cited by 72 | Viewed by 9351
Abstract
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. [...] Read more.
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science. Full article
(This article belongs to the Special Issue Pharmaceutical and Biotechnological Applications of Chitosan-Based Nanomaterials)
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