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Pharmaceutics
Special Issues
Novel Approaches in the Search for Active Compounds in Drug...
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Novel Approaches in the Search for Active Compounds in Drug Discovery and Development

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (1 April 2024) | Viewed by 2313

Special Issue Editors

Dr. Małgorzata Anna Marć

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Guest Editor
Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland
Interests: ADMETox; pharmacology; anticancer research; multidrug resistance; efflux pumps; cytotoxicity; apoptosis; antibacterial assays; pharmaceutical biotechnology; drug discovery & development; selenocompounds; small molecules; probiotics
Special Issues, Collections and Topics in MDPI journals
Dr. Enrique Domínguez-Álvarez

E-Mail Website
Guest Editor
Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC) Juan de la Cierva 3, 28006 Madrid, Spain
Interests: selenium; anticancer research; antibacterial activity; cancer multidrug resistance; bacterial multidrug resistance; efflux pumps; medicinal chemistry; organic synthesis; selenium chemistry; antifungal activity
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jadwiga Handzlik

E-Mail Website
Guest Editor
Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland
Interests: medicinal chemistry; synthesis; CADD; multidrug resistance; memory disorders; depression; Alzheimer’s disease; arrhythmia; ADMET; imidazolone; hydantoin; thiohydantoin; piperazine; selenium; chalcogen
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your research work results or review articles to our latest Special Issue. We especially encourage authors who work with novel approaches in the search for active small compounds in drug discovery and development. Authors can submit their works regarding both synthetic or natural compounds, with potential applications in multiple fields including cancer, microbiology, immunology and many other areas.

This Special Issue aims to provide an overview of the current findings regarding novel approaches in the search for active compounds with potential applications as novel drug candidates or adjuvants. In particular, we welcome research articles comprising aspects related to the synthesis, biological evaluation, and physico-chemistry of potential drug hits or the development of new methods in the drug discovery and development field.

In this Special Issue, both original research articles and reviews are welcome. Research areas may include (but are not limited to) the following topics: bioorganic chemistry, organic synthesis, biosynthesis, multidrug resistance, ADMETox aspects, novel compounds, drug candidates, and pharmaceutical biotechnology. Additionally, we are eager to publish studies with use in expounding the synthesis of future drug candidates or adjuvants in the fight against multidrug-resistant conditions, as well as works regarding the use of non-usual elements in organic compounds, such as transition metals and rare earth elements or heavy semimetals like selenium, tellurium, arsenic and iodine.

We look forward to receiving your contributions.

Dr. Małgorzata Anna Marć
Dr. Enrique Domínguez-Álvarez
Prof. Dr. Jadwiga Handzlik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug candidates
  • adjuvants
  • multidrug resistance
  • organic synthesis
  • ADMETox
  • cancer research
  • antimicrobial agents
  • immunology
  • novel approaches
  • drug discovery & development
  • transition metals
  • rare earth elements
  • selenium
  • tellurium
  • arsenic

Published Papers (2 papers)

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Research

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14 pages, 1523 KiB  
Article
Seleno-Warfare against Cancer: Decoding Antitumor Activity of Novel Acylselenoureas and Se-Acylisoselenoureas
by Eduardo Angulo-Elizari, Asif Raza, Ignacio Encío, Arun K. Sharma, Carmen Sanmartín and Daniel Plano
Pharmaceutics 2024, 16(2), 272; https://doi.org/10.3390/pharmaceutics16020272 - 14 Feb 2024
Viewed by 877
Abstract
Currently, cancer remains a global health problem. Despite the existence of several treatments, including chemotherapy, immunotherapy, and radiation therapy, the survival rate for most cancer patients, particularly those with metastasis, remains unsatisfactory. Thus, there is a continuous need to develop novel, effective therapies. [...] Read more.
Currently, cancer remains a global health problem. Despite the existence of several treatments, including chemotherapy, immunotherapy, and radiation therapy, the survival rate for most cancer patients, particularly those with metastasis, remains unsatisfactory. Thus, there is a continuous need to develop novel, effective therapies. In this work, 22 novel molecules containing selenium are reported, including seven Se-acylisoselenoureas synthesized from aliphatic carbodiimides as well as acylselenoureas with the same carbo- and heterocycles and aliphatic amines. After an initial screening at two doses (50 and 10 µM) in MDA-MB-231 (breast), HTB-54 (lung), DU-145 (prostate), and HCT-116 (colon) tumor cell lines, the ten most active compounds were identified. Additionally, these ten hits were also submitted to the DTP program of the NCI to study their cytotoxicity in a panel of 60 cancer cell lines. Compound 4 was identified as the most potent antiproliferative compound. The results obtained showed that compound 4 presented IC50 values lower than 10 µM in the cancer cell lines, although it was not the most selective one. Furthermore, compound 4 was found to inhibit cell growth and cause cell death by inducing apoptosis partially via ROS production. Overall, our results suggest that compound 4 could be a potential chemotherapeutic drug for different types of cancer. Full article
(This article belongs to the Special Issue Novel Approaches in the Search for Active Compounds in Drug Discovery and Development)
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Review

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50 pages, 10633 KiB  
Review
Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery
by Youri Cortat and Fabio Zobi
Pharmaceutics 2023, 15(10), 2398; https://doi.org/10.3390/pharmaceutics15102398 - 28 Sep 2023
Viewed by 811
Abstract
Coordination compounds featuring one or more antifungal azole (AA) ligands constitute an interesting family of candidate molecules, given their medicinal polyvalence and the viability of drug complexation as a strategy to improve and repurpose available medications. This review reports the work performed in [...] Read more.
Coordination compounds featuring one or more antifungal azole (AA) ligands constitute an interesting family of candidate molecules, given their medicinal polyvalence and the viability of drug complexation as a strategy to improve and repurpose available medications. This review reports the work performed in the field of coordination derivatives of AAs synthesized for medical purposes by discussing the corresponding publications and emphasizing the most promising compounds discovered so far. The resulting overview highlights the efficiency of AAs and their metallic species, as well as the potential still lying in this research area. Full article
(This article belongs to the Special Issue Novel Approaches in the Search for Active Compounds in Drug Discovery and Development)
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