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Compounds
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Organic Compounds with Biological Activity
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Organic Compounds with Biological Activity

A special issue of Compounds (ISSN 2673-6918).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 3249

Special Issue Editors

Dr. Enrique Domínguez-Álvarez

E-Mail Website
Guest Editor
Instituto de Química Orgánica General; Consejo Superior de Investigaciones Científicas (IQOG-CSIC) Juan de la Cierva 3, 28006 Madrid, Spain
Interests: selenium; anticancer research; antibacterial activity; cancer multidrug resistance; bacterial multidrug resistance; efflux pumps; medicinal chemistry; organic synthesis; selenium chemistry; antifungal activity; antibiotics; biofilms; selenium nanoparticles
Special Issues, Collections and Topics in MDPI journals
Dr. Małgorzata Anna Marć

E-Mail Website
Co-Guest Editor
Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland
Interests: ADMETox; pharmacology; anticancer research; multidrug resistance; efflux pumps; cytotoxicity; apoptosis; antibacterial assays; pharmaceutical biotechnology; drug discovery & development; selenocompounds; small molecules; probiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our society needs new developments both to support its own advancement, and to solve specific problems. In this context, chemistry can help through the identification of novel compounds that show biological activities. These novel compounds can be chemically synthesized or isolated and purified from natural sources, and can have novel promising applications against the treatment of diseases, in the management of plagues in agriculture and veterinary medicine, or in the disinfection of tools, spaces or surfaces, among other uses. In this Special Issue, we welcome works that report the initial synthesis/isolation/preparation/characterization and biological activities of chemical compounds that can serve future applications in biology, medicine, pharmacy, medicinal chemistry, agriculture, veterinary medicine and public health.

Dr. Enrique Domínguez-Álvarez
Dr. Małgorzata Anna Marć
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Compounds is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biological activity
  • medicinal chemistry
  • chemical compounds
  • active compounds
  • organic chemistry
  • synthesis
  • biological applications

Published Papers (2 papers)

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Research

11 pages, 2516 KiB  
Article
Protective Effect of Biflavones from Platonia insignis Mart. against Ethidium Bromide-Induced Lethality in Staphylococcus aureus
by Andressa Sabrina Guimarães Moura, Júlia de Andrade Ferreira Barreto, Andressa Kelly Ferreira e Silva, Maria Luísa Lima Barreto do Nascimento, Emanuelly Elanny Andrade Pinheiro, Arkellau Kenned Silva Moura, João Marcelo de Castro e Sousa, José de Souza Lima-Neto, Antonia Maria das Graças Lopes Citó, Henrique Douglas Melo Coutinho and Humberto Medeiros Barreto
Compounds 2023, 3(1), 194-204; https://doi.org/10.3390/compounds3010016 - 10 Feb 2023
Viewed by 1175
Abstract
Brazilian flora are highly diverse and have great potential for research into new medicines of plant origin. Platonia insignis Mart. is a fruit tree from the Amazon region with several potential pharmacological applications already demonstrated. The present study aimed to investigate the protective [...] Read more.
Brazilian flora are highly diverse and have great potential for research into new medicines of plant origin. Platonia insignis Mart. is a fruit tree from the Amazon region with several potential pharmacological applications already demonstrated. The present study aimed to investigate the protective effect of a mixture of the biflavones volkensiflavone and moreloflavone obtained from P. insignis flowers against the lethality induced by ethidium bromide in efflux pump overproducer strains of Staphylococcus aureus. Microdilution tests were performed to determine the minimum inhibitory concentration of ethidium bromide in the absence or presence of biflavones. The addition of biflavones to the growth medium increased the minimum inhibitory concentration of ethidium bromide against all strains tested, indicating that biflavones protected the bacterial cells against cell damage induced by this biocide agent. Comparative analysis of the infrared absorption spectra of each isolated compound, as well as of the associated compounds, demonstrated the complexation reaction, indicating that there was a preferential interaction between the H2N- groups of primary amines of ethidium bromide with the carbonyls of biflavones that formed imines -C=NH. Such complexation could reduce the amount of free ethidium bromide molecules available for DNA intercalation, resulting in the observed protective effect. These results suggest a possible technological application of the biflavones from P. insignis as protective agents against cell damage induced by ethidium bromide. Full article
(This article belongs to the Special Issue Organic Compounds with Biological Activity)
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13 pages, 2038 KiB  
Article
Reduction Potential Predictions for Thirty-Seven 1,4-di-N-Oxide Quinoxaline-2-Carboxamide Derivatives with Anti-Tuberculosis Activity
by Faranak Pooladian, Philip W. Crawford, Jonathan M. Kessler, Garrett R. Casey and Christina M. Ragain
Compounds 2023, 3(1), 83-95; https://doi.org/10.3390/compounds3010007 - 13 Jan 2023
Cited by 3 | Viewed by 1216
Abstract
The ability for density functional theory with the B3LYP functional with the lanl2dz basis set to predict the 1st (Wave 1) and 2nd (Wave 2) reductions of the diazine ring in a series of thirty-seven (37) 1,4-di-N-oxide quinoxaline-2-carboxamide derivatives in dimethylformamide was examined. [...] Read more.
The ability for density functional theory with the B3LYP functional with the lanl2dz basis set to predict the 1st (Wave 1) and 2nd (Wave 2) reductions of the diazine ring in a series of thirty-seven (37) 1,4-di-N-oxide quinoxaline-2-carboxamide derivatives in dimethylformamide was examined. The B3LYP/lanl2dz method had a strong correlation and low correlation to the experimental potentials for Wave 1 and Wave 2, respectively. There are nine identifiable analogs based on similarities of structure. The predicted reduction potentials for the derivatives of each analog generally fit the modified Hammett equation. The B3LYP/lanl2dz method is shown to be useful in accurately predicting the Wave 1 potentials for quinoxaline-di-N-oxide derivatives. For derivatives with assessable anti-tuberculosis activity, the predicted Wave 1 potentials have a similar correlation with the bioactivity when compared to the experimental wave 1 potentials. Full article
(This article belongs to the Special Issue Organic Compounds with Biological Activity)
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