Natural Nanoparticle for Cancer Diagnosis and Treatment, 2nd Edition
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: closed (10 June 2023) | Viewed by 7571
Special Issue Editor
Interests: nano-oncology; nano-drug delivery; protein nanocages; breast cancer; nano-tracers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the last twenty years, nanoparticles have been extensively studied as carriers for cancer imaging and drug delivery, since they are useful to improve bioavailability, tissue penetration, and circulation time of their cargo molecules. However, nanoparticle toxicity, immunogenicity, and sequestration by macrophages are issues that strongly limit their clinical translation. In this scenario, natural nanoparticles, such as exosomes and protein or DNA nanocages represent a charming alternative to synthetic metal or polymeric nanoparticles, thanks to their safety, biocompatibility, and biodegradability due to their biological nature. Their production and manipulation take place in mild conditions, preserving drug or probe functionality. Moreover, they generally display high stability in the physiological environment, allowing researchers to avoid common problems related to nanoparticle aggregation. They could also be modified by inserting surface functionalities to affect stability, surface charge, and ligand display, in order to maximize their bioavailability, tumor targeting, and tissue penetration. Moreover, natural nanoparticles are generally arranged to form a shell that displays three regions of interfaces, allowing researchers to realize multifunctional nanoparticles by combining nanoprobes for imaging with drug delivery devices. These features are strongly appealing in order to face cancer, where the development of tumor-targeted specific devices could be useful to improve patient compliance.
This Special Issue serves to depict the current landscape of natural nanoparticles developed to improve cancer management and we invite articles able to better highlight any feature of natural nanoparticles exploited for treatment of cancer.
Dr. Mazzucchelli Serena
Guest Editor
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Keywords
- natural nanoparticles
- drug delivery
- tumor-targeting probes
Related Special Issue
- Natural Nanoparticle for Cancer Diagnosis and Treatment in Pharmaceutics (11 articles)
