Natural Pharmaceuticals Focused on Anti-inflammatory Activities

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 620

Special Issue Editors

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Guest Editor
Scientific Department, Institute for Medicinal Plants Research “Dr Josif Pančić“, 11000 Belgrade, Serbia
Interests: phytochemistry; biological activity; phytotherapy; ethnomedicine; extractions; formulation of herbal products
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia
Interests: extraction of biologically active compounds from plants and fungi; encapsulation of biologically active compounds; biological activities of extracts and encapsulates; food and cosmetic safety

Special Issue Information

Dear Colleagues,

Plant and fungi kingdoms synthesize and store various bioactive compounds which are related to numerous health benefits in humans and animals. Additionally, many products from natural sources show significant anti-inflammatory effects. Since inflammation plays an important role in the development and progression of different illnesses, such as arthritis, asthma, cancer, cardiovascular, neurodegenerative, and autoimmune diseases, natural products possessing anti-inflammatory properties have attracted considerable scientific attention.

This Special Issue aims to present review papers and original articles focusing on current knowledge of bioactive natural products with anti-inflammatory properties. The results of anti-inflammatory activity studies documented in vitro and in vivo are appreciated. As for many natural products, there is a lack of data related to their bioactive compounds, and special emphasis is given to the submission of articles with biomolecular experiments. The identification and quantification of compounds with anti-inflammatory properties, their physicochemical characterization, mechanisms of biological activity, and relationships between structure and bioactivity (molecular docking) are welcome as well. Studies related to the complexes of natural products and carriers (as a system for controlled release) or natural products in the final formulation are also appreciated.

Research areas may include but are not limited to:

  • in vitro and in vivo study of anti-inflammatory activity of natural products
  • identification and quantification of compounds with anti-inflammatory properties and their physicochemical characterization
  • mechanisms of anti-inflammatory activity and structure-effect relationships
  • pharmaceutical formulations based on natural products with anti-inflammatory properties
  • delivery and controlled-release systems for natural products with anti-inflammatory properties
  • pharmaceutical process, engineering, biotechnology, and nanotechnology related to the production of natural anti-inflammatory agents
  • natural anti-inflammatory agent design and targeting
  • pharmacodynamics, pharmacokinetics (absorption, distribution, metabolism, and excretion), and toxicokinetics
  • physiological and biochemical effects of natural anti-inflammatory agents on the body

We look forward to receiving your contributions.

Dr. Katarina Šavikin
Dr. Aleksandra A. Jovanović
Guest Editors

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  • anti-inflammatory properties
  • chemical identification of natural anti-inflammatory agents
  • delivery and controlled-release systems
  • natural extracts
  • mechanisms of natural anti-inflammatory agents
  • molecular docking
  • natural products
  • plants and fungi
  • structure–effect relationships

Published Papers (1 paper)

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41 pages, 2188 KiB  
Vaccinium myrtillus L. Leaf Waste as a Source of Biologically Potent Compounds: Optimization of Polyphenol Extractions, Chemical Profile, and Biological Properties of the Extracts
by Muna Rajab Elferjane, Violeta Milutinović, Milica Jovanović Krivokuća, Mohammad J. Taherzadeh, Witold Pietrzak, Aleksandar Marinković and Aleksandra A. Jovanović
Pharmaceutics 2024, 16(6), 740; - 30 May 2024
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The aims of the present research include (1) optimization of extraction from Vaccinium myrtillus leaf waste via investigation of plant material:medium ratio, extraction medium, and extraction period, employing extractions at room and high temperatures, or using ultrasound and microwaves (M, HAE, UAE, and [...] Read more.
The aims of the present research include (1) optimization of extraction from Vaccinium myrtillus leaf waste via investigation of plant material:medium ratio, extraction medium, and extraction period, employing extractions at room and high temperatures, or using ultrasound and microwaves (M, HAE, UAE, and MAE, respectively), (2) physicochemical characterization, and (3) investigation of extract biological potential. The statistical analysis revealed that optimal levels of parameters for the greatest polyphenolic yield were a proportion of 1:30 g/mL, ethyl alcohol 50% (v/v) during 2 min of microwave irradiation. By LC-MS analysis, 29 phenolic components were detected; HAE showed the highest richness of almost all determined polyphenols, while chlorogenic acid and quercetin 3-O-glucuronide were dominant. All extracts showed a high inhibition of Staphylococcus aureus growth. The effect of different parameters on extracts’ antioxidant capacity depended on the used tests. The extracts also showed a stimulative influence on keratinocyte viability and anti-inflammatory activity (proven in cell-based ELISA and erythrocyte stabilization assays). The extraction procedure significantly affected the extraction yield (MAE ≥ maceration ≥ UAE ≥ HAE), whereas conductivity, density, surface tension, and viscosity varied in a narrow range. The presented research provides evidence on the optimal extraction conditions and technique, chemical composition, and antioxidant, antimicrobial, anti-inflammatory, and keratinocyte viability properties of bilberry extracts for potential applications in pharmacy and cosmetics. Full article
(This article belongs to the Special Issue Natural Pharmaceuticals Focused on Anti-inflammatory Activities)
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